TissGeneSummary for SIRPD |
Gene summary |
Basic gene information | Gene symbol | SIRPD |
Gene name | signal-regulatory protein delta | |
Synonyms | PTPNS1L2|dJ576H24.4 | |
Cytomap | UCSC genome browser: 20p13 | |
Type of gene | protein-coding | |
RefGenes | NM_178460.2, | |
Description | SIRP-deltaprotein tyrosine phosphatase non-receptor type substrate 1-like 2protein tyrosine phosphatase, non-receptor type substrate 1-like 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000125900 | ||
HPRD : 17931 | ||
Vega : OTTHUMG00000031674 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SIRPD | |
BioGPS: 128646 | ||
Pathway | NCI Pathway Interaction Database: SIRPD | |
KEGG: SIRPD | ||
REACTOME: SIRPD | ||
Pathway Commons: SIRPD | ||
Context | iHOP: SIRPD | |
ligand binding site mutation search in PubMed: SIRPD | ||
UCL Cancer Institute: SIRPD | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SIRPD | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SIRPD |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.024573507 | -1.188962396 | 1.164388889 | 1.09E-15 | 5.73E-15 |
LUAD | -0.372274178 | 1.439548236 | -1.811822414 | 9.86E-23 | 2.91E-21 |
LUSC | -0.789788377 | 1.556260643 | -2.34604902 | 5.93E-30 | 2.62E-28 |
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TissGene-miRNA for SIRPD |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SIRPD |
TissGeneSNV for SIRPD |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F120L | LIHC | 2 |
p.S6F | SKCM | 2 |
p.V180I | LUAD | 1 |
p.E172Q | HNSC | 1 |
p.R133W | COAD | 1 |
p.R72W | UCEC | 1 |
p.E172K | SKCM | 1 |
p.E88Q | BLCA | 1 |
p.P2L | LUAD | 1 |
p.K197N | LIHC | 1 |
p.P182T | LGG | 1 |
p.S168L | STAD | 1 |
p.F100Y | SKCM | 1 |
p.H161D | SKCM | 1 |
p.E106Q | CHOL | 1 |
p.E172D | BLCA | 1 |
p.H160Q | LUAD | 1 |
p.E88K | SKCM | 1 |
p.E22K | SKCM | 1 |
p.E45K | SKCM | 1 |
p.E106K | CESC | 1 |
p.R72Q | LUAD | 1 |
p.R133P | LUAD | 1 |
p.R187Q | GBM | 1 |
p.E128K | SKCM | 1 |
p.F83S | KIRC | 1 |
p.G60E | SKCM | 1 |
p.R103C | BLCA | 1 |
p.E88K | SARC | 1 |
p.E106* | BLCA | 1 |
p.K73I | LUSC | 1 |
p.X198Q | READ | 1 |
p.K79E | UCEC | 1 |
p.R103H | STAD | 1 |
p.N149T | SKCM | 1 |
p.N77S | UCEC | 1 |
p.V118M | HNSC | 1 |
p.P84S | SKCM | 1 |
p.R133L | LUAD | 1 |
p.L194F | ACC | 1 |
p.R187G | SKCM | 1 |
p.G67E | SKCM | 1 |
p.N82D | UCEC | 1 |
p.V180I | COAD | 1 |
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TissGeneCNV for SIRPD |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SIRPD |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SIRPD |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SIRPD |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SIRPD |
TissGeneDrug for SIRPD |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SIRPD |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |