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TissGeneSummary for CSTL1 |
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Basic gene information | Gene symbol | CSTL1 |
Gene name | cystatin-like 1 | |
Synonyms | CTES1|RCET11|dJ322G13.4 | |
Cytomap | UCSC genome browser: 20p11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_138283.1, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000125823 | ||
HPRD : 16770 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CSTL1 | |
BioGPS: 128817 | ||
Pathway | NCI Pathway Interaction Database: CSTL1 | |
KEGG: CSTL1 | ||
REACTOME: CSTL1 | ||
Pathway Commons: CSTL1 | ||
Context | iHOP: CSTL1 | |
ligand binding site mutation search in PubMed: CSTL1 | ||
UCL Cancer Institute: CSTL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CSTL1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for CSTL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CSTL1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CSTL1 |
TissGeneSNV for CSTL1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R69* | UCEC | 2 |
p.R63Q | UCEC | 1 |
p.R63* | SKCM | 1 |
p.G77R | UCEC | 1 |
p.W88R | COAD | 1 |
p.G4E | SKCM | 1 |
p.Q104E | LUSC | 1 |
p.R93M | UCEC | 1 |
p.D95E | LUAD | 1 |
p.P9S | SKCM | 1 |
p.S51F | SKCM | 1 |
p.R63X | STAD | 1 |
p.A20T | SKCM | 1 |
p.A15T | PCPG | 1 |
p.R93K | SKCM | 1 |
p.S100F | SKCM | 1 |
p.C101Y | LUAD | 1 |
p.R69* | SKCM | 1 |
p.Q128* | SKCM | 1 |
p.K85N | BLCA | 1 |
p.H24D | BLCA | 1 |
p.Q26R | LUAD | 1 |
p.D58N | SKCM | 1 |
p.R63* | STAD | 1 |
p.L10P | HNSC | 1 |
p.F47V | STAD | 1 |
p.R63Q | SKCM | 1 |
p.K39N | UCEC | 1 |
p.K39Q | COAD | 1 |
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TissGeneCNV for CSTL1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CSTL1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI544560 | CSTL1-TNS3 | chr20:23421451 | chr7:47364287 |
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TissGeneNet for CSTL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CSTL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CSTL1 |
TissGeneDrug for CSTL1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CSTL1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0030567 | Parkinson Disease | 1 | GAD |