![]() |
TissGeneSummary for CST9 |
![]() |
Basic gene information | Gene symbol | CST9 |
Gene name | cystatin 9 (testatin) | |
Synonyms | CLM|CTES7A | |
Cytomap | UCSC genome browser: 20p11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_001008693.2, | |
Description | cystatin-9cystatin-like molecule | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000173335 | ||
HPRD : 16768 | ||
Vega : OTTHUMG00000032076 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CST9 | |
BioGPS: 128822 | ||
Pathway | NCI Pathway Interaction Database: CST9 | |
KEGG: CST9 | ||
REACTOME: CST9 | ||
Pathway Commons: CST9 | ||
Context | iHOP: CST9 | |
ligand binding site mutation search in PubMed: CST9 | ||
UCL Cancer Institute: CST9 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Breast | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCA | |
Reference showing the relevant tissue of CST9 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CST9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -1.518344487 | 1.062352388 | -2.580696875 | 9.87E-09 | 7.53E-08 |
KICH | -1.518344487 | 1.201891513 | -2.720236 | 1.09E-09 | 6.75E-09 |
KIRC | -1.468629209 | 0.730877735 | -2.199506944 | 2.73E-22 | 2.52E-21 |
Top |
TissGene-miRNA for CST9 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CST9 |
TissGeneSNV for CST9 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E107K | SKCM | 2 |
p.V91M | UCEC | 1 |
p.E32K | SKCM | 1 |
p.E120K | UCEC | 1 |
p.R87* | MESO | 1 |
p.W77* | BLCA | 1 |
p.R78S | LUAD | 1 |
p.T57I | LUAD | 1 |
p.R155M | COAD | 1 |
p.G127S | LGG | 1 |
p.M35I | GBM | 1 |
p.D156Y | LUAD | 1 |
p.C139R | ACC | 1 |
p.R72H | ACC | 1 |
p.P154T | LUAD | 1 |
p.Q61H | LGG | 1 |
p.G145D | BRCA | 1 |
p.L121M | LUAD | 1 |
p.N112S | COAD | 1 |
p.G147R | GBM | 1 |
p.G37C | LUAD | 1 |
p.E79X | THYM | 1 |
p.P114S | SKCM | 1 |
p.A148E | LUAD | 1 |
p.G158E | SKCM | 1 |
p.S129I | ACC | 1 |
Top |
TissGeneCNV for CST9 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for CST9 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CST9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CST9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for CST9 |
TissGeneDrug for CST9 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CST9 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001925 | Albuminuria | 1 | GAD |
umls:C0004623 | Bacterial Infections | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0022658 | Kidney Diseases | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1368683 | Epithelioma | 1 | BeFree |