TissGeneSummary for DUSP15 |
Gene summary |
Basic gene information | Gene symbol | DUSP15 |
Gene name | dual specificity phosphatase 15 | |
Synonyms | VHY | |
Cytomap | UCSC genome browser: 20q11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_001012644.1, NM_080611.3,NM_177991.1, | |
Description | VH1-related member Ydual specificity phosphatase-like 15dual specificity protein phosphatase 15vaccinia virus VH1-related dual-specific protein phosphatase Y | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000149599 | ||
HPRD : 13252 | ||
Vega : OTTHUMG00000032182 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUSP15 | |
BioGPS: 128853 | ||
Pathway | NCI Pathway Interaction Database: DUSP15 | |
KEGG: DUSP15 | ||
REACTOME: DUSP15 | ||
Pathway Commons: DUSP15 | ||
Context | iHOP: DUSP15 | |
ligand binding site mutation search in PubMed: DUSP15 | ||
UCL Cancer Institute: DUSP15 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DUSP15 | ||
Description by TissGene annotations | Cancer gene Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DUSP15 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 1.710704357 | 3.217273107 | -1.50656875 | 1.13E-05 | 4.67E-05 |
THCA | 0.571617016 | 1.798525491 | -1.226908475 | 7.29E-10 | 4.29E-09 |
PRAD | -1.352268479 | 0.096454598 | -1.448723077 | 2.57E-08 | 2.82E-07 |
KIRC | -0.555800851 | 2.652789427 | -3.208590278 | 8.58E-28 | 1.34E-26 |
KICH | 5.947274982 | 3.097530982 | 2.849744 | 2.59E-07 | 1.09E-06 |
COAD | -1.351185787 | -2.508035787 | 1.15685 | 0.00507 | 0.012166889 |
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TissGene-miRNA for DUSP15 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-506-3p | MIMAT0002878 | 0.02 | -0.28 | 78 |
ACC | hsa-miR-506-3p | MIMAT0002878 | 0.02 | -0.28 | 78 |
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TissGeneMut for DUSP15 |
TissGeneSNV for DUSP15 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E236K | SKCM | 2 |
p.P269A | LUAD | 1 |
p.G27C | COAD | 1 |
p.A122T | BLCA | 1 |
p.Q155R | KIRC | 1 |
p.A53T | PAAD | 1 |
p.V94L | COAD | 1 |
p.Q141P | LUAD | 1 |
p.N125D | LUSC | 1 |
p.S252L | SKCM | 1 |
p.H72Y | SKCM | 1 |
p.R295C | STAD | 1 |
p.Q131* | STAD | 1 |
p.N80I | LUAD | 1 |
p.A56V | COAD | 1 |
p.V94L | READ | 1 |
p.V94L | KIRP | 1 |
p.L62W | SKCM | 1 |
p.Q134X | STAD | 1 |
p.R52C | STAD | 1 |
p.S292P | STAD | 1 |
p.E3K | SKCM | 1 |
p.G79R | SKCM | 1 |
p.E236K | HNSC | 1 |
p.R262C | CESC | 1 |
p.R49C | STAD | 1 |
p.H75Y | SKCM | 1 |
p.H66Q | UCEC | 1 |
p.D227E | LUAD | 1 |
p.A289T | PAAD | 1 |
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TissGeneCNV for DUSP15 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DUSP15 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A3IS-01A | NCOA3-DUSP15 | 5UTR-5UTR | Chr20:46130763 | Chr20:30454956 |
TCGAfusionPortal | PRADA | BLCA | TCGA-K4-A3WS-01A | DNMT3B-DUSP15 | CDS-5UTR | Chr20:31376818 | Chr20:30457400 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7421-01A | TPX2-DUSP15 | Out-of-frame | Chr20:30347982 | Chr20:30438479 |
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TissGeneNet for DUSP15 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DUSP15 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DUSP15 |
TissGeneDrug for DUSP15 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DUSP15 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |