TissGeneSummary for NEU4 |
Gene summary |
Basic gene information | Gene symbol | NEU4 |
Gene name | sialidase 4 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q37.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001167599.2, NM_001167600.2,NM_001167601.2,NM_001167602.2,NM_080741.3, | |
Description | N-acetyl-alpha-neuraminidase 4neuraminidase 4sialidase-4 | |
Modification date | 20141222 | |
dbXrefs | MIM : 608527 | |
HGNC : HGNC | ||
Ensembl : ENSG00000204099 | ||
HPRD : 12249 | ||
Vega : OTTHUMG00000133412 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NEU4 | |
BioGPS: 129807 | ||
Pathway | NCI Pathway Interaction Database: NEU4 | |
KEGG: NEU4 | ||
REACTOME: NEU4 | ||
Pathway Commons: NEU4 | ||
Context | iHOP: NEU4 | |
ligand binding site mutation search in PubMed: NEU4 | ||
UCL Cancer Institute: NEU4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGLIHC | |
Reference showing the relevant tissue of NEU4 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006516 | glycoprotein catabolic process | 15213228 | GO:0006689 | ganglioside catabolic process | 15213228 | GO:0009313 | oligosaccharide catabolic process | 15213228 | GO:0006516 | glycoprotein catabolic process | 15213228 | GO:0006689 | ganglioside catabolic process | 15213228 | GO:0009313 | oligosaccharide catabolic process | 15213228 |
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TissGeneExp for NEU4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -1.905070037 | 1.787776838 | -3.692846875 | 6.64E-12 | 9.42E-11 |
COAD | 2.181538136 | 5.331945829 | -3.150407692 | 6.07E-08 | 4.46E-07 |
LIHC | 2.903237213 | 5.670693213 | -2.767456 | 1.03E-05 | 4.34E-05 |
KICH | -3.211172787 | 1.260935213 | -4.472108 | 2.30E-14 | 3.80E-13 |
KIRC | -1.679581842 | 0.598316769 | -2.277898611 | 9.62E-12 | 3.78E-11 |
ESCA | 0.598983941 | -2.258097877 | 2.857081818 | 0.00244 | 0.025314654 |
HNSC | -1.79322367 | -0.333053903 | -1.460169767 | 0.00318 | 0.009208494 |
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TissGene-miRNA for NEU4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NEU4 |
TissGeneSNV for NEU4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E315K | SKCM | 2 |
p.R15Q | SKCM | 1 |
p.T109M | BLCA | 1 |
p.G75R | OV | 1 |
p.R5C | PRAD | 1 |
p.R53C | LUAD | 1 |
p.V424A | ESCA | 1 |
p.W410C | LUAD | 1 |
p.L12F | SKCM | 1 |
p.S420C | SKCM | 1 |
p.E14K | SKCM | 1 |
p.T35S | LUAD | 1 |
p.G474E | SKCM | 1 |
p.H209R | ESCA | 1 |
p.A479T | STAD | 1 |
p.S451F | SKCM | 1 |
p.A70S | ESCA | 1 |
p.P43L | BRCA | 1 |
p.S148L | ESCA | 1 |
p.R30S | PAAD | 1 |
p.N463K | BLCA | 1 |
p.Q55R | LUSC | 1 |
p.G310D | SKCM | 1 |
p.P317L | LUAD | 1 |
p.E16K | SKCM | 1 |
p.Q338K | LUAD | 1 |
p.F468L | GBM | 1 |
p.P270T | LUAD | 1 |
p.A226T | SKCM | 1 |
p.V113M | SKCM | 1 |
p.G301R | COAD | 1 |
p.T60M | SKCM | 1 |
p.S169L | CESC | 1 |
p.G206S | HNSC | 1 |
p.G343D | SKCM | 1 |
p.D203N | SKCM | 1 |
p.L396V | HNSC | 1 |
p.S65F | SKCM | 1 |
p.L214I | LUAD | 1 |
p.A80V | COAD | 1 |
p.C186* | PRAD | 1 |
p.S135L | ESCA | 1 |
p.P468S | SKCM | 1 |
p.R18C | PRAD | 1 |
p.A227V | READ | 1 |
p.R180H | PAAD | 1 |
p.W274* | LUAD | 1 |
p.W167X | CHOL | 1 |
p.P483H | LUAD | 1 |
p.R22Q | GBM | 1 |
p.R265C | BLCA | 1 |
p.G230C | LUAD | 1 |
p.P286S | SKCM | 1 |
p.P303L | SKCM | 1 |
p.A226V | READ | 1 |
p.V24M | LUAD | 1 |
p.L461P | COAD | 1 |
p.P7T | PRAD | 1 |
p.D144Y | LIHC | 1 |
p.N99S | LIHC | 1 |
p.N86H | BLCA | 1 |
p.A466T | STAD | 1 |
p.A83S | ESCA | 1 |
p.G355R | SKCM | 1 |
p.P484H | LUSC | 1 |
p.P108R | BRCA | 1 |
p.R5C | BLCA | 1 |
p.V411A | ESCA | 1 |
p.A104T | LUAD | 1 |
p.R398C | UCEC | 1 |
p.G118R | SKCM | 1 |
p.P29S | SKCM | 1 |
p.G63R | COAD | 1 |
p.R123C | COAD | 1 |
p.R17S | PAAD | 1 |
p.P330H | LUAD | 1 |
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TissGeneCNV for NEU4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NEU4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NEU4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NEU4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NEU4 |
TissGeneDrug for NEU4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NEU4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |