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| TissGeneSummary for ACMSD |
 Gene summary |
| Basic gene information | Gene symbol | ACMSD |
| Gene name | aminocarboxymuconate semialdehyde decarboxylase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 2q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_138326.2, | |
| Description | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylasepicolinate carboxylase | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 608889 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000153086 | ||
| HPRD : 12326 | ||
| Vega : OTTHUMG00000131711 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACMSD | |
| BioGPS: 130013 | ||
| Pathway | NCI Pathway Interaction Database: ACMSD | |
| KEGG: ACMSD | ||
| REACTOME: ACMSD | ||
| Pathway Commons: ACMSD | ||
| Context | iHOP: ACMSD | |
| ligand binding site mutation search in PubMed: ACMSD | ||
| UCL Cancer Institute: ACMSD | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of ACMSD | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0046874 | quinolinate metabolic process | 12140278 | GO:0046874 | quinolinate metabolic process | 12140278 |
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| TissGeneExp for ACMSD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -1.396290877 | -2.977432256 | 1.581141379 | 1.73E-05 | 4.92E-05 |
| KICH | -2.658644946 | 5.691887054 | -8.350532 | 6.52E-19 | 3.59E-17 |
| LIHC | 6.805375054 | 8.100321054 | -1.294946 | 0.000255 | 0.000799936 |
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| TissGene-miRNA for ACMSD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ACMSD |
| TissGeneSNV for ACMSD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R183Q | SKCM | 2 |
| p.R59C | SKCM | 2 |
| p.R243H | STAD | 2 |
| p.G140R | KIRP | 1 |
| p.R131H | UCEC | 1 |
| p.D270N | LUSC | 1 |
| p.E13* | UCEC | 1 |
| p.A154V | UCEC | 1 |
| p.Q120R | HNSC | 1 |
| p.P159S | SKCM | 1 |
| p.R59C | UCEC | 1 |
| p.E165K | SKCM | 1 |
| p.E135D | UCEC | 1 |
| p.Y23* | HNSC | 1 |
| p.A121V | STAD | 1 |
| p.G113V | GBM | 1 |
| p.M308V | COAD | 1 |
| p.P190S | UCEC | 1 |
| p.A326E | HNSC | 1 |
| p.G194E | CESC | 1 |
| p.V147I | READ | 1 |
| p.G234E | SKCM | 1 |
| p.M253I | SKCM | 1 |
| p.W54* | BLCA | 1 |
| p.A248T | UCEC | 1 |
| p.R109K | SKCM | 1 |
| p.R332K | SKCM | 1 |
| p.L95I | STAD | 1 |
| p.R50X | COAD | 1 |
| p.P190H | UCEC | 1 |
| p.M63I | SKCM | 1 |
| p.D270E | READ | 1 |
| p.V147A | LIHC | 1 |
| p.M1I | SKCM | 1 |
| p.G115E | SKCM | 1 |
| p.L10V | LUAD | 1 |
| p.Q142L | SKCM | 1 |
| p.M178I | ESCA | 1 |
| p.F46V | STAD | 1 |
| p.I3S | UCEC | 1 |
| p.E149K | SKCM | 1 |
| p.G67E | LUAD | 1 |
| p.R59C | COAD | 1 |
| p.W54* | SKCM | 1 |
| p.W22* | SKCM | 1 |
| p.R243C | UCEC | 1 |
| p.M129I | SKCM | 1 |
| p.W191* | SKCM | 1 |
| p.G24R | SKCM | 1 |
| p.Y161C | STAD | 1 |
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| TissGeneCNV for ACMSD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ACMSD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A5QQ-01A | RAB3GAP1-ACMSD | Out-of-frame | Chr2:135851263 | Chr2:135655911 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12Q-01A | RAB3GAP1-ACMSD | In-frame | Chr2:135893502 | Chr2:135616831 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A15S-01A | SESTD1-ACMSD | 5UTR-CDS | Chr2:180129226 | Chr2:135655911 |
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| TissGeneNet for ACMSD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| COAD (tumor) | COAD (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| KICH (tumor) | KICH (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| STAD (tumor) | STAD (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| THCA (tumor) | THCA (normal) |
| ACMSD, MAGEA11 (tumor) | ACMSD, MAGEA11 (normal) |
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| TissGeneProg for ACMSD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ACMSD |
| TissGeneDrug for ACMSD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ACMSD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | GWASCAT |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3698239 | Cerebral cortex myoclonus | 1 | BeFree |
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