TissGeneSummary for REG3G |
Gene summary |
Basic gene information | Gene symbol | REG3G |
Gene name | regenerating islet-derived 3 gamma | |
Synonyms | LPPM429|PAP IB|PAP-1B|PAP1B|PAPIB|REG III|REG-III|UNQ429 | |
Cytomap | UCSC genome browser: 2p12 | |
Type of gene | protein-coding | |
RefGenes | NM_001008387.2, NM_001270040.1,NM_198448.3, | |
Description | REG-3-gammapancreatitis-associated protein 1Bpancreatitis-associated protein IBreg III-gammaregenerating gene IIIregenerating islet-derived protein 3-gammaregenerating islet-derived protein III-gamma | |
Modification date | 20141207 | |
dbXrefs | MIM : 609933 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143954 | ||
HPRD : 10137 | ||
Vega : OTTHUMG00000130018 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_REG3G | |
BioGPS: 130120 | ||
Pathway | NCI Pathway Interaction Database: REG3G | |
KEGG: REG3G | ||
REACTOME: REG3G | ||
Pathway Commons: REG3G | ||
Context | iHOP: REG3G | |
ligand binding site mutation search in PubMed: REG3G | ||
UCL Cancer Institute: REG3G | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTGCT | |
Reference showing the relevant tissue of REG3G | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for REG3G |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 3.734851559 | 1.652635934 | 2.082215625 | 0.00847 | 0.018951836 |
KICH | -0.585017191 | 0.789406809 | -1.374424 | 0.000737 | 0.001630871 |
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TissGene-miRNA for REG3G |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for REG3G |
TissGeneSNV for REG3G |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S86F | SKCM | 2 |
p.G85E | SKCM | 2 |
p.P137S | SKCM | 2 |
p.E32K | SKCM | 2 |
p.G43S | LUAD | 2 |
p.G144C | BRCA | 1 |
p.E28Q | ESCA | 1 |
p.K172M | BLCA | 1 |
p.D160Y | BLCA | 1 |
p.P137A | PRAD | 1 |
p.I95F | LUAD | 1 |
p.S89F | HNSC | 1 |
p.C40Y | LUSC | 1 |
p.L156V | HNSC | 1 |
p.X176Y | COAD | 1 |
p.P8S | UCEC | 1 |
p.F55L | UCEC | 1 |
p.P4A | ESCA | 1 |
p.R151G | LUAD | 1 |
p.D65Y | LUAD | 1 |
p.M128I | BLCA | 1 |
p.L141* | HNSC | 1 |
p.P41R | LUAD | 1 |
p.G74E | SKCM | 1 |
p.W133* | LUAD | 1 |
p.C163S | LGG | 1 |
p.Y52C | LGG | 1 |
p.G85E | SARC | 1 |
p.L20I | UCEC | 1 |
p.A46S | PRAD | 1 |
p.K42* | LUAD | 1 |
p.S73P | LIHC | 1 |
p.G147W | LUAD | 1 |
p.D175H | LUAD | 1 |
p.W122* | SKCM | 1 |
p.P50T | LUAD | 1 |
p.P50L | SKCM | 1 |
p.P137L | SKCM | 1 |
p.P72S | SKCM | 1 |
p.P72H | LUSC | 1 |
p.W133* | LUSC | 1 |
p.Q69* | LUSC | 1 |
p.Q111K | HNSC | 1 |
p.P4H | LUAD | 1 |
p.P50H | LUAD | 1 |
p.L91M | LUAD | 1 |
p.S124I | LUSC | 1 |
p.R151G | STAD | 1 |
p.L141V | STAD | 1 |
p.L91Q | HNSC | 1 |
p.V127M | UCS | 1 |
p.G82V | ESCA | 1 |
p.S11Y | LUSC | 1 |
p.S9N | UCEC | 1 |
p.Q25K | CHOL | 1 |
p.N162T | STAD | 1 |
p.P8A | HNSC | 1 |
p.C146* | LUSC | 1 |
p.C146F | ESCA | 1 |
p.L149M | KIRC | 1 |
p.K70* | LUSC | 1 |
p.E28* | LUAD | 1 |
p.M5V | LUAD | 1 |
p.H99Y | SKCM | 1 |
p.S39R | PAAD | 1 |
p.C171F | KIRC | 1 |
p.S94C | LUAD | 1 |
p.S148N | SKCM | 1 |
p.H145Y | SKCM | 1 |
p.P168S | LUAD | 1 |
p.K59N | ESCA | 1 |
p.D108Y | HNSC | 1 |
p.P137T | LUAD | 1 |
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TissGeneCNV for REG3G |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for REG3G |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCEC | TCGA-B5-A3FD-01A | CTNNA2-REG3G | CDS-5'UTR | chr2:79878784 | chr2:79253108 |
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TissGeneNet for REG3G |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for REG3G |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for REG3G |
TissGeneDrug for REG3G |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for REG3G |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |