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| TissGeneSummary for ADH7 |
 Gene summary |
| Basic gene information | Gene symbol | ADH7 |
| Gene name | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | |
| Synonyms | ADH4 | |
| Cytomap | UCSC genome browser: 4q23-q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000673.4, NM_001166504.1, | |
| Description | alcohol dehydrogenase VIIalcohol dehydrogenase class 4 mu/sigma chainalcohol dehydrogenase class IV mu/sigma chainalcohol dehydrogenase-7class IV sigma-1 alcohol dehydrogenaseclass IV sigmasigma alcohol dehydrogenasegastric alcohol dehydrogenaseret | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600086 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196344 | ||
| HPRD : 02515 | ||
| Vega : OTTHUMG00000159318 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADH7 | |
| BioGPS: 131 | ||
| Pathway | NCI Pathway Interaction Database: ADH7 | |
| KEGG: ADH7 | ||
| REACTOME: ADH7 | ||
| Pathway Commons: ADH7 | ||
| Context | iHOP: ADH7 | |
| ligand binding site mutation search in PubMed: ADH7 | ||
| UCL Cancer Institute: ADH7 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCALUAD,LUSC | |
| Reference showing the relevant tissue of ADH7 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0001523 | retinoid metabolic process | 9600267 | GO:0006069 | ethanol oxidation | 10969996 | GO:0009617 | response to bacterium | 11410738 | GO:0010430 | fatty acid omega-oxidation | 9600267 | GO:0045471 | response to ethanol | 9600267 | GO:0055114 | oxidation-reduction process | 7876099 | GO:1900116 | extracellular negative regulation of signal transduction | 9600267 | GO:0001523 | retinoid metabolic process | 9600267 | GO:0006069 | ethanol oxidation | 10969996 | GO:0009617 | response to bacterium | 11410738 | GO:0010430 | fatty acid omega-oxidation | 9600267 | GO:0045471 | response to ethanol | 9600267 | GO:0055114 | oxidation-reduction process | 7876099 | GO:1900116 | extracellular negative regulation of signal transduction | 9600267 |
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| TissGeneExp for ADH7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -0.073608862 | 4.607119263 | -4.680728125 | 7.55E-06 | 9.18E-05 |
| LUSC | 5.09651669 | 1.279585317 | 3.816931373 | 1.14E-06 | 2.85E-06 |
| ESCA | 0.751157331 | 5.846275513 | -5.095118182 | 0.00604 | 0.044627774 |
| HNSC | 5.62252435 | 7.765145281 | -2.14262093 | 0.0129 | 0.030617089 |
| LUAD | -0.536921039 | 0.679815168 | -1.216736207 | 0.00274 | 0.005556799 |
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| TissGene-miRNA for ADH7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ADH7 |
| TissGeneSNV for ADH7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R129K | SKCM | 2 |
| p.G134S | SKCM | 2 |
| p.S177F | SKCM | 2 |
| p.R141K | SKCM | 2 |
| p.S189F | SKCM | 2 |
| p.P203L | BRCA | 1 |
| p.P96R | SKCM | 1 |
| p.R312C | ESCA | 1 |
| p.V247E | THCA | 1 |
| p.H150N | CESC | 1 |
| p.P305L | STAD | 1 |
| p.R58L | ESCA | 1 |
| p.R38C | SKCM | 1 |
| p.R117H | COAD | 1 |
| p.R38C | THCA | 1 |
| p.G56E | SKCM | 1 |
| p.R125C | ACC | 1 |
| p.P325L | STAD | 1 |
| p.R381* | UCEC | 1 |
| p.R60H | PAAD | 1 |
| p.E112* | UCEC | 1 |
| p.H138Q | SKCM | 1 |
| p.R117C | ACC | 1 |
| p.I160T | SARC | 1 |
| p.K197N | UCEC | 1 |
| p.K159M | LGG | 1 |
| p.V235E | THCA | 1 |
| p.K73M | SKCM | 1 |
| p.P104S | SKCM | 1 |
| p.D161N | SKCM | 1 |
| p.R48H | PAAD | 1 |
| p.D304N | SKCM | 1 |
| p.W314* | SKCM | 1 |
| p.T285A | STAD | 1 |
| p.R68H | PAAD | 1 |
| p.N106K | LUAD | 1 |
| p.R105C | ACC | 1 |
| p.A194S | LUAD | 1 |
| p.E160K | UCEC | 1 |
| p.G299V | LUAD | 1 |
| p.P307S | BRCA | 1 |
| p.Y264H | PAAD | 1 |
| p.W314C | LUAD | 1 |
| p.D125N | SKCM | 1 |
| p.R50C | SKCM | 1 |
| p.K61M | SKCM | 1 |
| p.M58V | LGG | 1 |
| p.D173N | SKCM | 1 |
| p.I77F | ACC | 1 |
| p.P191A | LUAD | 1 |
| p.I85F | ACC | 1 |
| p.P166L | SKCM | 1 |
| p.T13A | KIRC | 1 |
| p.M257I | SKCM | 1 |
| p.T143K | HNSC | 1 |
| p.W314* | SARC | 1 |
| p.S289R | LUAD | 1 |
| p.K10Q | SKCM | 1 |
| p.A182S | LUAD | 1 |
| p.V274M | BRCA | 1 |
| p.Y284H | PAAD | 1 |
| p.L322F | BLCA | 1 |
| p.V196I | SARC | 1 |
| p.P178L | SKCM | 1 |
| p.R117C | GBM | 1 |
| p.G179E | SKCM | 1 |
| p.S262I | ESCA | 1 |
| p.T131K | HNSC | 1 |
| p.S206* | HNSC | 1 |
| p.I65F | ACC | 1 |
| p.H150Q | SKCM | 1 |
| p.G191E | SKCM | 1 |
| p.G193C | LUSC | 1 |
| p.E36K | BLCA | 1 |
| p.P63Q | LUAD | 1 |
| p.D128N | SKCM | 1 |
| p.W326C | LUAD | 1 |
| p.K171M | LGG | 1 |
| p.G214E | SKCM | 1 |
| p.Y276H | PAAD | 1 |
| p.T277A | STAD | 1 |
| p.R332C | ESCA | 1 |
| p.G146S | SKCM | 1 |
| p.E17G | SKCM | 1 |
| p.E29G | SKCM | 1 |
| p.P108R | SKCM | 1 |
| p.G192V | LUAD | 1 |
| p.A280P | LUAD | 1 |
| p.G287V | LUAD | 1 |
| p.G202E | SKCM | 1 |
| p.P92S | SKCM | 1 |
| p.S226P | COAD | 1 |
| p.T13I | UCEC | 1 |
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| TissGeneCNV for ADH7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ADH7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-XP-A8T8-01A | ADH7-ABCG2 | CDS-5'UTR | chr4:100336634 | chr4:89061166 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8EY-01A | ADH7-KDM1B | In-Frame | chr4:100348929 | chr6:18212718 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-6940-01A | ADH7-CXCR5 | 3UTR-5UTR | Chr4:100333418 | Chr11:118754475 |
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| TissGeneNet for ADH7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| COAD (tumor) | COAD (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| KICH (tumor) | KICH (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| STAD (tumor) | STAD (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| THCA (tumor) | THCA (normal) |
| ADH7, CAND1 (tumor) | ADH7, CAND1 (normal) |
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| TissGeneProg for ADH7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ADH7 |
| TissGeneDrug for ADH7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ADH7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 16 | BeFree,GAD |
| umls:C0038580 | Substance Dependence | 5 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 3 | GAD |
| umls:C1510472 | Drug Dependence | 3 | BeFree,GAD |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,GAD |
| umls:C0393571 | Multiple System Atrophy | 2 | BeFree,GAD |
| umls:C0001956 | alcohol use disorder | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0011849 | Diabetes Mellitus | 1 | GAD |
| umls:C0014859 | Esophageal Neoplasms | 1 | CTD_human,GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0023055 | Laryngeal neoplasm | 1 | CTD_human,GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 1 | CTD_human |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0029295 | Oropharyngeal Neoplasms | 1 | GAD |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0031347 | Pharyngeal Neoplasms | 1 | CTD_human |
| umls:C0035334 | Retinitis Pigmentosa | 1 | BeFree |
| umls:C0037019 | Shy-Drager Syndrome | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0085762 | Alcohol abuse | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | GAD |
| umls:C0236970 | Alcohol-Induced Disorders | 1 | GAD |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C3887873 | Hearing Loss | 1 | GAD |
| umls:C3160718 | PARKINSON DISEASE, LATE-ONSET | 0 | MGD |
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