TissGeneSummary for UROC1 |
Gene summary |
Basic gene information | Gene symbol | UROC1 |
Gene name | urocanate hydratase 1 | |
Synonyms | HMFN0320 | |
Cytomap | UCSC genome browser: 3q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001165974.1, NM_144639.2, | |
Description | imidazolonepropionate hydrolaseurocanase 1urocanase domain containing 1urocanate hydratase | |
Modification date | 20141207 | |
dbXrefs | MIM : 613012 | |
HGNC : HGNC | ||
Ensembl : ENSG00000159650 | ||
HPRD : 08712 | ||
Vega : OTTHUMG00000162753 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UROC1 | |
BioGPS: 131669 | ||
Pathway | NCI Pathway Interaction Database: UROC1 | |
KEGG: UROC1 | ||
REACTOME: UROC1 | ||
Pathway Commons: UROC1 | ||
Context | iHOP: UROC1 | |
ligand binding site mutation search in PubMed: UROC1 | ||
UCL Cancer Institute: UROC1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of UROC1 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for UROC1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 4.066142146 | 9.276658146 | -5.210516 | 6.35E-12 | 1.07E-10 |
KIRP | -1.330164104 | -2.407439104 | 1.077275 | 0.00124 | 0.003333429 |
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TissGene-miRNA for UROC1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for UROC1 |
TissGeneSNV for UROC1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R510H | STAD | 1 |
p.D398E | GBM | 1 |
p.G241R | LUAD | 1 |
p.I526V | LUAD | 1 |
p.V595L | LUAD | 1 |
p.E308K | SKCM | 1 |
p.G604A | LUAD | 1 |
p.R173Q | SKCM | 1 |
p.R582H | PRAD | 1 |
p.L331I | HNSC | 1 |
p.R642C | READ | 1 |
p.P30H | UCEC | 1 |
p.W597X | SKCM | 1 |
p.P359S | SKCM | 1 |
p.W313* | LUAD | 1 |
p.R543Q | SKCM | 1 |
p.P431T | PAAD | 1 |
p.E667* | CESC | 1 |
p.D390G | LIHC | 1 |
p.P62S | SKCM | 1 |
p.R556K | SKCM | 1 |
p.A61S | LUSC | 1 |
p.P15L | SKCM | 1 |
p.K485N | STAD | 1 |
p.A230V | HNSC | 1 |
p.A6E | LUSC | 1 |
p.P359L | SKCM | 1 |
p.A369S | SARC | 1 |
p.V627L | BLCA | 1 |
p.Q425H | UCEC | 1 |
p.V600A | PRAD | 1 |
p.D612N | READ | 1 |
p.Q412H | BLCA | 1 |
p.E336K | SKCM | 1 |
p.V379I | SKCM | 1 |
p.S443C | UCEC | 1 |
p.L36I | STAD | 1 |
p.D330G | LIHC | 1 |
p.D460N | KIRC | 1 |
p.T97M | READ | 1 |
p.S565F | SKCM | 1 |
p.S9A | LIHC | 1 |
p.S186F | SKCM | 1 |
p.V520M | COAD | 1 |
p.G413S | OV | 1 |
p.T97K | BRCA | 1 |
p.D294N | SKCM | 1 |
p.E150* | LUAD | 1 |
p.E278D | LUAD | 1 |
p.G611D | SKCM | 1 |
p.D273N | SKCM | 1 |
p.A615G | CESC | 1 |
p.A260T | STAD | 1 |
p.E302K | OV | 1 |
p.S253N | ESCA | 1 |
p.D515E | SKCM | 1 |
p.R519C | ESCA | 1 |
p.H315R | STAD | 1 |
p.T246S | ACC | 1 |
p.W685* | LUSC | 1 |
p.S382N | SKCM | 1 |
p.E328K | LUAD | 1 |
p.R169H | THCA | 1 |
p.S186P | STAD | 1 |
p.R579C | ESCA | 1 |
p.S337P | OV | 1 |
p.A29T | COAD | 1 |
p.S382C | STAD | 1 |
p.R295C | UCEC | 1 |
p.C532Y | UCEC | 1 |
p.R14W | UCEC | 1 |
p.R450H | STAD | 1 |
p.E395Q | BLCA | 1 |
p.H375R | STAD | 1 |
p.A414S | HNSC | 1 |
p.G566D | PAAD | 1 |
p.D520N | KIRC | 1 |
p.F345S | SKCM | 1 |
p.R188Q | COAD | 1 |
p.R324S | LUAD | 1 |
p.R232Q | SKCM | 1 |
p.S637L | BLCA | 1 |
p.R304K | SKCM | 1 |
p.D291H | BLCA | 1 |
p.D612Y | ESCA | 1 |
p.E362G | LIHC | 1 |
p.A352S | LUAD | 1 |
p.G214S | SKCM | 1 |
p.Q365H | UCEC | 1 |
p.E557K | SKCM | 1 |
p.A255D | STAD | 1 |
p.R450H | PRAD | 1 |
p.G316D | KICH | 1 |
p.R46S | SKCM | 1 |
p.G506D | PAAD | 1 |
p.G72R | STAD | 1 |
p.E395* | CESC | 1 |
p.G251R | STAD | 1 |
p.G264R | UCEC | 1 |
p.D440E | CESC | 1 |
p.G352V | CESC | 1 |
p.A597V | PAAD | 1 |
p.G404D | UCEC | 1 |
p.P491T | PAAD | 1 |
p.Q358* | LUAD | 1 |
p.E63Q | BLCA | 1 |
p.G214S | COAD | 1 |
p.S654N | CESC | 1 |
p.D291N | BRCA | 1 |
p.S443Y | LUAD | 1 |
p.R361M | LUAD | 1 |
p.G344D | BLCA | 1 |
p.S503C | UCEC | 1 |
p.D666G | UCEC | 1 |
p.D666E | LUAD | 1 |
p.N560K | CESC | 1 |
p.V374M | STAD | 1 |
p.V434M | STAD | 1 |
p.K545N | STAD | 1 |
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TissGeneCNV for UROC1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for UROC1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for UROC1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for UROC1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for UROC1 |
TissGeneDrug for UROC1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for UROC1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004134 | Ataxia | 1 | CTD_human |
umls:C0025362 | Mental Retardation | 1 | BeFree |
umls:C0268514 | Urocanase deficiency | 1 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0741270 | Intermittent ataxia | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | CTD_human |