TissGeneSummary for CMBL |
Gene summary |
Basic gene information | Gene symbol | CMBL |
Gene name | carboxymethylenebutenolidase homolog (Pseudomonas) | |
Synonyms | JS-1 | |
Cytomap | UCSC genome browser: 5p15.2 | |
Type of gene | protein-coding | |
RefGenes | NM_138809.3, | |
Description | carboxymethylenebutenolidase homologcarboxymethylenebutenolidase-like (Pseudomonas) | |
Modification date | 20141207 | |
dbXrefs | MIM : 613379 | |
HGNC : HGNC | ||
HPRD : 14055 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CMBL | |
BioGPS: 134147 | ||
Pathway | NCI Pathway Interaction Database: CMBL | |
KEGG: CMBL | ||
REACTOME: CMBL | ||
Pathway Commons: CMBL | ||
Context | iHOP: CMBL | |
ligand binding site mutation search in PubMed: CMBL | ||
UCL Cancer Institute: CMBL | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of CMBL | ||
Description by TissGene annotations | Protective TissGene in OS TissgsLTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CMBL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 3.10368704 | 4.48297304 | -1.379286 | 1.49E-05 | 6.05E-05 |
COAD | 1.981256732 | 3.621256732 | -1.64 | 4.59E-08 | 3.49E-07 |
KICH | 1.69089104 | 3.23300304 | -1.542112 | 8.82E-06 | 2.81E-05 |
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TissGene-miRNA for CMBL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CMBL |
TissGeneSNV for CMBL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W54* | UCEC | 1 |
p.V154I | COAD | 1 |
p.P9L | GBM | 1 |
p.P228L | SKCM | 1 |
p.G20E | SKCM | 1 |
p.K168N | UCEC | 1 |
p.M65I | SKCM | 1 |
p.H14R | LUAD | 1 |
p.W240* | HNSC | 1 |
p.T206P | READ | 1 |
p.G70R | SKCM | 1 |
p.I12V | LUSC | 1 |
p.E232K | BLCA | 1 |
p.R217L | UCEC | 1 |
p.Q82L | LIHC | 1 |
p.D231E | ESCA | 1 |
p.P9L | SKCM | 1 |
p.N178K | KIRP | 1 |
p.V154I | LUSC | 1 |
p.P95S | SKCM | 1 |
p.D179N | SKCM | 1 |
p.E28G | LUSC | 1 |
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TissGeneCNV for CMBL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CMBL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU507510 | CMBL-AATF | chr5:10290712 | chr17:35316472 | |
Chimerdb3.0 | ChiTaRs | NA | AA421821 | CMBL-DCAF8 | chr5:10279705 | chr1:160227509 | |
Chimerdb3.0 | ChiTaRs | NA | AA602984 | CMBL-FAM76A | chr5:10279785 | chr1:28064261 | |
Chimerdb3.0 | ChiTaRs | NA | BE813357 | DENR-CMBL | chr12:123254614 | chr5:10279956 | |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-1016-01A | CMBL-DARS2 | 5UTR-CDS | Chr5:10307737 | Chr1:173819465 |
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TissGeneNet for CMBL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CMBL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CMBL |
TissGeneDrug for CMBL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CMBL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |