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| TissGeneSummary for POC5 |
 Gene summary |
| Basic gene information | Gene symbol | POC5 |
| Gene name | POC5 centriolar protein | |
| Synonyms | C5orf37 | |
| Cytomap | UCSC genome browser: 5q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099271.1, NM_152408.2, | |
| Description | POC5 centriolar protein homologcentrosomal protein POC5hPOC5protein of centriole 5proteome of centriole 5 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000152359 | ||
| HPRD : 08188 | ||
| Vega : OTTHUMG00000162487 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_POC5 | |
| BioGPS: 134359 | ||
| Pathway | NCI Pathway Interaction Database: POC5 | |
| KEGG: POC5 | ||
| REACTOME: POC5 | ||
| Pathway Commons: POC5 | ||
| Context | iHOP: POC5 | |
| ligand binding site mutation search in PubMed: POC5 | ||
| UCL Cancer Institute: POC5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
| Reference showing the relevant tissue of POC5 | ||
| Description by TissGene annotations | Cancer gene TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for POC5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for POC5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for POC5 |
| TissGeneSNV for POC5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M1I | UCEC | 1 |
| p.A429T | STAD | 1 |
| p.A201G | LUAD | 1 |
| p.E345D | UCEC | 1 |
| p.P415L | SKCM | 1 |
| p.N173H | UCEC | 1 |
| p.L58S | SKCM | 1 |
| p.T413I | UCEC | 1 |
| p.P472S | UCEC | 1 |
| p.I502L | LIHC | 1 |
| p.G394* | LUAD | 1 |
| p.A488P | LUAD | 1 |
| p.F347S | COAD | 1 |
| p.N383H | LIHC | 1 |
| p.S136Y | READ | 1 |
| p.P452L | SKCM | 1 |
| p.S437L | UCEC | 1 |
| p.S550L | CESC | 1 |
| p.P525L | PRAD | 1 |
| p.S136Y | UCEC | 1 |
| p.P418S | PRAD | 1 |
| p.R227I | UCEC | 1 |
| p.S517L | BLCA | 1 |
| p.F252L | UCEC | 1 |
| p.H200Y | ESCA | 1 |
| p.R289C | SARC | 1 |
| p.K384T | LUAD | 1 |
| p.H569N | ESCA | 1 |
| p.K385N | KIRC | 1 |
| p.K344Q | COAD | 1 |
| p.E387Q | HNSC | 1 |
| p.E336K | BLCA | 1 |
| p.S25L | SKCM | 1 |
| p.E82D | DLBC | 1 |
| p.S152P | DLBC | 1 |
| p.Q563K | PRAD | 1 |
| p.Q314H | LUSC | 1 |
| p.T134A | GBM | 1 |
| p.F252L | ESCA | 1 |
| p.A446T | LGG | 1 |
| p.R558I | LUAD | 1 |
| p.S404* | LUAD | 1 |
| p.R19Q | LUSC | 1 |
| p.R227K | BLCA | 1 |
| p.T172_splice | UCEC | 1 |
| p.D379N | STAD | 1 |
| p.I85T | UCS | 1 |
| p.Q371X | READ | 1 |
| p.A405P | LIHC | 1 |
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| TissGeneCNV for POC5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for POC5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for POC5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for POC5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for POC5 |
| TissGeneDrug for POC5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for POC5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 1 | GWASCAT |
| umls:C0575157 | Deformity of spine | 1 | BeFree |
| umls:C0595995 | Idiopathic scoliosis | 1 | BeFree |
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