TissGeneSummary for ACOT12 |
Gene summary |
Basic gene information | Gene symbol | ACOT12 |
Gene name | acyl-CoA thioesterase 12 | |
Synonyms | CACH-1|Cach|STARD15|THEAL | |
Cytomap | UCSC genome browser: 5q14.1 | |
Type of gene | protein-coding | |
RefGenes | NM_130767.2, | |
Description | START domain-containing protein 15StAR-related lipid transfer (START) domain containing 15acyl-CoA thioester hydrolase 12acyl-coenzyme A thioesterase 12cytoplasmic acetyl-CoA hydrolase 1cytosolic acetyl-CoA hydrolasehCACH-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614315 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172497 | ||
HPRD : 16680 | ||
Vega : OTTHUMG00000131305 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACOT12 | |
BioGPS: 134526 | ||
Pathway | NCI Pathway Interaction Database: ACOT12 | |
KEGG: ACOT12 | ||
REACTOME: ACOT12 | ||
Pathway Commons: ACOT12 | ||
Context | iHOP: ACOT12 | |
ligand binding site mutation search in PubMed: ACOT12 | ||
UCL Cancer Institute: ACOT12 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ACOT12 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACOT12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.944115009 | 2.880858602 | -4.824973611 | 8.13E-62 | 9.11E-59 |
KICH | -1.58983912 | 2.63440488 | -4.224244 | 6.33E-13 | 7.75E-12 |
KIRP | -1.17797612 | 2.877477005 | -4.055453125 | 1.21E-13 | 2.34E-12 |
THCA | -1.237886713 | -2.248564679 | 1.010677966 | 4.05E-07 | 1.63E-06 |
LIHC | 6.14561688 | 8.47709088 | -2.331474 | 1.48E-08 | 1.26E-07 |
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TissGene-miRNA for ACOT12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACOT12 |
TissGeneSNV for ACOT12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R147* | UCEC | 3 |
p.R405C | SKCM | 2 |
p.L435M | THYM | 1 |
p.S531F | SKCM | 1 |
p.W416* | LUAD | 1 |
p.R324C | SKCM | 1 |
p.R147X | READ | 1 |
p.R320C | KICH | 1 |
p.D463Y | ESCA | 1 |
p.P191S | SKCM | 1 |
p.R405H | LUAD | 1 |
p.E335X | STAD | 1 |
p.D548Y | SKCM | 1 |
p.E44K | SKCM | 1 |
p.R405H | UCEC | 1 |
p.I303N | HNSC | 1 |
p.R405H | BLCA | 1 |
p.R324H | LUSC | 1 |
p.S182Y | THYM | 1 |
p.R322Q | UCEC | 1 |
p.R279C | UCEC | 1 |
p.Y314D | LIHC | 1 |
p.P191A | SKCM | 1 |
p.G237R | SKCM | 1 |
p.D293G | LIHC | 1 |
p.E335* | STAD | 1 |
p.Q256E | BLCA | 1 |
p.Q256K | STAD | 1 |
p.F81L | PAAD | 1 |
p.S502R | READ | 1 |
p.A107T | MESO | 1 |
p.D95Y | READ | 1 |
p.S473L | THCA | 1 |
p.R315Q | UCEC | 1 |
p.A537D | LUAD | 1 |
p.E260D | PCPG | 1 |
p.D170V | SKCM | 1 |
p.R405C | UCEC | 1 |
p.L128P | LIHC | 1 |
p.H437Y | BLCA | 1 |
p.E160K | SKCM | 1 |
p.G180D | ESCA | 1 |
p.R279H | PAAD | 1 |
p.R405C | STAD | 1 |
p.E260K | SKCM | 1 |
p.A364S | COAD | 1 |
p.R147* | PAAD | 1 |
p.S218I | UCEC | 1 |
p.L129P | LUAD | 1 |
p.R322* | UCEC | 1 |
p.T200I | LUAD | 1 |
p.W368X | SKCM | 1 |
p.E63Q | SKCM | 1 |
p.W368* | SKCM | 1 |
p.R219S | LUAD | 1 |
p.S182Y | LUAD | 1 |
p.S84N | STAD | 1 |
p.R322Q | COAD | 1 |
p.E62Q | BLCA | 1 |
p.F555V | LIHC | 1 |
p.E44Q | BLCA | 1 |
p.E44V | BLCA | 1 |
p.S177F | SKCM | 1 |
p.D353N | SKCM | 1 |
p.T211A | GBM | 1 |
p.G180D | UCEC | 1 |
p.R315Q | LUAD | 1 |
p.R457Q | SKCM | 1 |
p.D446G | LIHC | 1 |
p.E151A | DLBC | 1 |
p.I73M | HNSC | 1 |
p.L525V | CESC | 1 |
p.V135M | STAD | 1 |
p.W391L | LUAD | 1 |
p.P441L | SKCM | 1 |
p.R147X | PAAD | 1 |
p.E86D | HNSC | 1 |
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TissGeneCNV for ACOT12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACOT12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A24Z-01A | IQGAP2-ACOT12 | Out-of-frame | Chr5:75866482 | Chr5:80626759 |
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TissGeneNet for ACOT12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACOT12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACOT12 |
TissGeneDrug for ACOT12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACOT12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1858991 | Childhood Ataxia with Central Nervous System Hypomyelinization | 1 | BeFree |