TissGeneSummary for PACRG |
Gene summary |
Basic gene information | Gene symbol | PACRG |
Gene name | PARK2 co-regulated | |
Synonyms | GLUP|HAK005771|PARK2CRG | |
Cytomap | UCSC genome browser: 6q26 | |
Type of gene | protein-coding | |
RefGenes | NM_001080378.1, NM_001080379.1,NM_152410.2, | |
Description | molecular chaperone/chaperonin-binding proteinparkin co-regulated gene proteinparkin coregulated gene protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 608427 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112530 | ||
HPRD : 07465 | ||
Vega : OTTHUMG00000016116 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PACRG | |
BioGPS: 135138 | ||
Pathway | NCI Pathway Interaction Database: PACRG | |
KEGG: PACRG | ||
REACTOME: PACRG | ||
Pathway Commons: PACRG | ||
Context | iHOP: PACRG | |
ligand binding site mutation search in PubMed: PACRG | ||
UCL Cancer Institute: PACRG | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PACRG | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PACRG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.746375827 | 1.674286918 | -2.420662745 | 2.58E-09 | 8.52E-09 |
STAD | -1.132314492 | 0.712432383 | -1.844746875 | 2.31E-07 | 5.30E-06 |
THCA | 0.271734608 | 1.503853252 | -1.232118644 | 7.23E-11 | 4.97E-10 |
KIRP | 1.127963633 | 3.318832383 | -2.19086875 | 4.67E-09 | 3.81E-08 |
KIRC | 0.197533078 | 3.374012245 | -3.176479167 | 2.12E-26 | 2.88E-25 |
LUAD | -0.964706625 | 1.789789927 | -2.754496552 | 3.60E-12 | 2.66E-11 |
BRCA | -1.497475621 | 0.766581397 | -2.264057018 | 8.53E-32 | 1.22E-30 |
HNSC | -2.387664564 | 0.022681947 | -2.410346512 | 4.72E-11 | 1.02E-09 |
BLCA | -1.24727913 | 0.995131397 | -2.242410526 | 0.00168 | 0.010989176 |
ESCA | -1.621755685 | 0.777453406 | -2.399209091 | 0.000342 | 0.007384544 |
COAD | -1.963827713 | -0.923796943 | -1.040030769 | 0.000288 | 0.000941803 |
KICH | 5.831406133 | 3.650334133 | 2.181072 | 7.06E-05 | 0.000190689 |
LIHC | 0.242552133 | 1.770096133 | -1.527544 | 4.44E-05 | 0.000165457 |
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TissGene-miRNA for PACRG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PACRG |
TissGeneSNV for PACRG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P122L | SKCM | 2 |
p.P122S | SKCM | 2 |
p.R73* | SKCM | 2 |
p.L157V | STAD | 1 |
p.H107Y | SKCM | 1 |
p.P14A | LUAD | 1 |
p.G276* | UCEC | 1 |
p.S89L | COAD | 1 |
p.R162* | UCEC | 1 |
p.V286M | STAD | 1 |
p.E269* | STAD | 1 |
p.G130V | SARC | 1 |
p.Q192* | LGG | 1 |
p.E99D | COAD | 1 |
p.A71V | PRAD | 1 |
p.N11S | STAD | 1 |
p.R128L | ESCA | 1 |
p.I199F | ESCA | 1 |
p.H107N | LUSC | 1 |
p.R162* | PAAD | 1 |
p.W96* | GBM | 1 |
p.V286L | LUAD | 1 |
p.L172F | GBM | 1 |
p.R73Q | BLCA | 1 |
p.L157F | LUAD | 1 |
p.L175R | PAAD | 1 |
p.L263* | HNSC | 1 |
p.Q192H | READ | 1 |
p.E269X | STAD | 1 |
p.P152L | BRCA | 1 |
p.G139E | SKCM | 1 |
p.H106Y | LUSC | 1 |
p.P152L | UCEC | 1 |
p.H107D | BRCA | 1 |
p.R273H | UCEC | 1 |
p.G249S | STAD | 1 |
p.S89L | SKCM | 1 |
p.Q26L | LUAD | 1 |
p.Q148H | STAD | 1 |
p.F126L | SKCM | 1 |
p.R160X | COAD | 1 |
p.R73Q | SARC | 1 |
p.R73X | SKCM | 1 |
p.P57L | SKCM | 1 |
p.V53A | SKCM | 1 |
p.V287F | LUAD | 1 |
p.A59E | LUAD | 1 |
p.R191C | COAD | 1 |
p.R73Q | UCEC | 1 |
p.E118A | LUAD | 1 |
p.R73Q | COAD | 1 |
p.P34S | STAD | 1 |
p.G276V | LUAD | 1 |
p.D251V | STAD | 1 |
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TissGeneCNV for PACRG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PACRG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI690188 | OTP-PACRG | chr5:76931867 | chr6:163536378 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E9-A1ND-01A | QKI-PACRG | In-Frame | chr6:163899928 | chr6:163483181 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A0XU-01A | QKI-PACRG | In-Frame | chr6:163899928 | chr6:163483181 |
Chimerdb3.0 | FusionScan | UCEC | TCGA-A5-A1OH-01A | AGAP1-PACRG | Out-of-Frame | chr2:236792093 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-55-6986-11A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-55-8512-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-AJ-A3OK-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-EO-A22Y-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-DI-A2QY-11A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-SJ-A6ZJ-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-2E-A9G8-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-D1-A3JQ-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-AJ-A3NH-11A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-AJ-A8CT-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-PG-A916-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-BG-A0MK-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-B5-A11R-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-85-8352-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510439 | chr6:163735858 |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-37-4129-01A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
Chimerdb3.0 | TopHat-Fusion | LUSC | TCGA-43-5670-11A | PACRG-PACRG-AS1 | Out-of-Frame | chr6:163510438 | chr6:163735857 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0XU-01A | QKI-PACRG | In-frame | Chr6:163899928 | Chr6:163483182 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1ND-01A | QKI-PACRG | In-frame | Chr6:163899928 | Chr6:163483182 |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A1OV-01A | QKI-PACRG | In-frame | Chr6:163899928 | Chr6:163483182 |
TCGAfusionPortal | PRADA | HNSC | TCGA-BA-4077-01B | NSMCE2-PACRG | Out-of-frame | Chr8:126114729 | Chr6:163235179 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-8301-01A | QKI-PACRG | Out-of-frame | Chr6:163836367 | Chr6:163483182 |
TCGAfusionPortal | PRADA | LUSC | TCGA-33-6738-01A | QKI-PACRG | Out-of-frame | Chr6:163836367 | Chr6:163483182 |
TCGAfusionPortal | PRADA | OV | TCGA-24-1842-01A | QKI-PACRG | Out-of-frame | Chr6:163899928 | Chr6:163733811 |
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TissGeneNet for PACRG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PACRG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PACRG |
TissGeneDrug for PACRG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PACRG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023343 | Leprosy | 10 | BeFree,CTD_human,GAD |
umls:C0030567 | Parkinson Disease | 3 | GAD,LHGDN |
umls:C0041296 | Tuberculosis | 2 | GAD,LHGDN |
umls:C0005699 | Blast Phase | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | GAD |
umls:C0023418 | leukemia | 1 | BeFree,LHGDN |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
umls:C0029294 | Orofaciodigital Syndromes | 1 | BeFree |
umls:C0030528 | Paratyphoid Fever | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0041466 | Typhoid Fever | 1 | BeFree |
umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 1 | BeFree,LHGDN |
umls:C0687120 | Nephronophthisis | 1 | BeFree |
umls:C1510460 | Orofaciodigital Syndrome I | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |