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| TissGeneSummary for CPA2 |
 Gene summary |
| Basic gene information | Gene symbol | CPA2 |
| Gene name | carboxypeptidase A2 (pancreatic) | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001869.2, | |
| Description | carboxypeptidase A2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600688 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000158516 | ||
| HPRD : 02821 | ||
| Vega : OTTHUMG00000157019 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPA2 | |
| BioGPS: 1358 | ||
| Pathway | NCI Pathway Interaction Database: CPA2 | |
| KEGG: CPA2 | ||
| REACTOME: CPA2 | ||
| Pathway Commons: CPA2 | ||
| Context | iHOP: CPA2 | |
| ligand binding site mutation search in PubMed: CPA2 | ||
| UCL Cancer Institute: CPA2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of CPA2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CPA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.575981933 | 1.114058418 | -1.690040351 | 2.54E-21 | 2.01E-20 |
| ESCA | 0.075927796 | 6.473345977 | -6.397418182 | 0.00554 | 0.042340069 |
| STAD | 1.207925523 | 4.319034898 | -3.111109375 | 0.00278 | 0.01190899 |
| COAD | 0.636735138 | 1.926419754 | -1.289684615 | 0.00137 | 0.003818919 |
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| TissGene-miRNA for CPA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CPA2 |
| TissGeneSNV for CPA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E104K | SKCM | 2 |
| p.P70S | SKCM | 2 |
| p.R386H | PRAD | 2 |
| p.K322T | STAD | 1 |
| p.Q75R | LUAD | 1 |
| p.G406A | STAD | 1 |
| p.V414M | SKCM | 1 |
| p.E105X | STAD | 1 |
| p.E182D | LUAD | 1 |
| p.G225A | HNSC | 1 |
| p.R415P | HNSC | 1 |
| p.R240W | READ | 1 |
| p.T207I | KIRC | 1 |
| p.K292N | OV | 1 |
| p.V95L | LUAD | 1 |
| p.A189T | SKCM | 1 |
| p.R114Q | UCEC | 1 |
| p.K56E | GBM | 1 |
| p.I30T | SKCM | 1 |
| p.S151F | BLCA | 1 |
| p.L311M | LUAD | 1 |
| p.Q395H | BLCA | 1 |
| p.S145R | PRAD | 1 |
| p.V290L | LUAD | 1 |
| p.E154D | COAD | 1 |
| p.M3V | HNSC | 1 |
| p.A280T | LUAD | 1 |
| p.R415Q | SARC | 1 |
| p.G24V | LUAD | 1 |
| p.R392C | OV | 1 |
| p.Y316H | STAD | 1 |
| p.E132* | UCEC | 1 |
| p.R394H | THYM | 1 |
| p.G166V | LUSC | 1 |
| p.E104* | BLCA | 1 |
| p.E127K | SKCM | 1 |
| p.E105* | STAD | 1 |
| p.S376* | BLCA | 1 |
| p.R181Q | LGG | 1 |
| p.S307C | LUAD | 1 |
| p.I16V | LGG | 1 |
| p.P418S | SKCM | 1 |
| p.A11T | BLCA | 1 |
| p.D325N | TGCT | 1 |
| p.M3I | LUAD | 1 |
| p.F80L | UCEC | 1 |
| p.H49L | SARC | 1 |
| p.S339Y | UCEC | 1 |
| p.M411T | BLCA | 1 |
| p.P61A | LUAD | 1 |
| p.P223H | LUAD | 1 |
| p.H179N | BRCA | 1 |
| p.H306Y | SKCM | 1 |
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| TissGeneCNV for CPA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CPA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5JY-01A | CREB3L2-CPA2 | In-Frame | chr7:137686349 | chr7:129921943 |
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| TissGeneNet for CPA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| CPA2, HNF4A (tumor) | CPA2, HNF4A (normal) |
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| TissGeneProg for CPA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CPA2 |
| TissGeneDrug for CPA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CPA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003130 | Anoxia | 1 | CTD_human |
| umls:C0004352 | Autistic Disorder | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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