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| TissGeneSummary for CPB2 |
 Gene summary |
| Basic gene information | Gene symbol | CPB2 |
| Gene name | carboxypeptidase B2 (plasma) | |
| Synonyms | CPU|PCPB|TAFI | |
| Cytomap | UCSC genome browser: 13q14.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001278541.1, NM_001872.4,NM_016413.3, | |
| Description | carboxypeptidase B-like proteincarboxypeptidase B2carboxypeptidase B2 (plasma, carboxypeptidase U)carboxypeptidase Rthrombin-activable fibrinolysis inhibitorthrombin-activatable fibrinolysis inhibitor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603101 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000080618 | ||
| HPRD : 04374 | ||
| Vega : OTTHUMG00000016867 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPB2 | |
| BioGPS: 1361 | ||
| Pathway | NCI Pathway Interaction Database: CPB2 | |
| KEGG: CPB2 | ||
| REACTOME: CPB2 | ||
| Pathway Commons: CPB2 | ||
| Context | iHOP: CPB2 | |
| ligand binding site mutation search in PubMed: CPB2 | ||
| UCL Cancer Institute: CPB2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CPB2 | ||
| Description by TissGene annotations | Cancer gene TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CPB2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.853765191 | 6.683716915 | -5.829951724 | 8.58E-24 | 3.10E-22 |
| LUSC | -0.776589272 | 6.229746022 | -7.006335294 | 2.80E-34 | 2.87E-32 |
| LIHC | 10.58916685 | 11.93802685 | -1.34886 | 3.75E-05 | 0.000141887 |
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| TissGene-miRNA for CPB2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CPB2 |
| TissGeneSNV for CPB2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.W264R | STAD | 1 |
| p.W238* | LUSC | 1 |
| p.S285L | STAD | 1 |
| p.E138K | SKCM | 1 |
| p.E134X | STAD | 1 |
| p.E286Q | HNSC | 1 |
| p.F244C | CESC | 1 |
| p.G206E | SKCM | 1 |
| p.S334C | HNSC | 1 |
| p.V72X | COAD | 1 |
| p.D60N | BLCA | 1 |
| p.A170S | LUAD | 1 |
| p.G227D | SKCM | 1 |
| p.R342C | PRAD | 1 |
| p.E276K | LUSC | 1 |
| p.Y282C | UCEC | 1 |
| p.G393R | STAD | 1 |
| p.I205M | KIRC | 1 |
| p.D375E | UCEC | 1 |
| p.G88E | LUAD | 1 |
| p.A117V | LGG | 1 |
| p.P366A | BRCA | 1 |
| p.R236Q | STAD | 1 |
| p.D78N | CESC | 1 |
| p.G206R | SKCM | 1 |
| p.G88* | LUAD | 1 |
| p.R287Q | READ | 1 |
| p.W264* | BLCA | 1 |
| p.T253I | LIHC | 1 |
| p.L376F | BLCA | 1 |
| p.P56L | UCEC | 1 |
| p.R421S | LIHC | 1 |
| p.R236* | LGG | 1 |
| p.Q103* | BLCA | 1 |
| p.V222M | LUSC | 1 |
| p.S164F | COAD | 1 |
| p.K233R | UCEC | 1 |
| p.K2T | COAD | 1 |
| p.T145I | READ | 1 |
| p.W238R | UCEC | 1 |
| p.G319D | COAD | 1 |
| p.E50* | HNSC | 1 |
| p.H148D | ESCA | 1 |
| p.F70L | KIRP | 1 |
| p.N85T | LUAD | 1 |
| p.E398K | CESC | 1 |
| p.P287T | LUAD | 1 |
| p.E134* | STAD | 1 |
| p.Q122* | UCEC | 1 |
| p.E339* | UCEC | 1 |
| p.L3F | READ | 1 |
| p.K414Q | OV | 1 |
| p.Y49H | BLCA | 1 |
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| TissGeneCNV for CPB2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CPB2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A1LG-01A | WWP1-CPB2 | In-Frame | chr8:87474075 | chr13:46661955 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1LG-01A | WWP1-CPB2 | In-frame | Chr8:87474075 | Chr13:46661955 |
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| TissGeneNet for CPB2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| COAD (tumor) | COAD (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| KICH (tumor) | KICH (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| STAD (tumor) | STAD (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| THCA (tumor) | THCA (normal) |
| CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (tumor) | CPB2, HNF4A, UBC, PLG, HNF1A, A2M, F2, C5, PZP, TINAG (normal) |
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| TissGeneProg for CPB2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CPB2 |
| TissGeneDrug for CPB2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CPB2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0038454 | Cerebrovascular accident | 9 | BeFree,GAD,LHGDN |
| umls:C0027051 | Myocardial Infarction | 7 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 5 | BeFree,GAD |
| umls:C0151942 | Arterial thrombosis | 5 | BeFree |
| umls:C0040053 | Thrombosis | 4 | GAD,LHGDN |
| umls:C0149871 | Deep Vein Thrombosis | 4 | BeFree,GAD |
| umls:C0007137 | Squamous cell carcinoma | 3 | BeFree,GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 3 | BeFree |
| umls:C0040038 | Thromboembolism | 3 | BeFree |
| umls:C0242339 | Dyslipidemias | 3 | BeFree |
| umls:C0398623 | Thrombophilia | 3 | BeFree |
| umls:C0948008 | Ischemic stroke | 3 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 3 | BeFree,GAD,LHGDN |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 3 | BeFree |
| umls:C0004943 | Behcet Syndrome | 2 | BeFree,GAD,LHGDN |
| umls:C0005779 | Blood Coagulation Disorders | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree,GAD |
| umls:C0007785 | Cerebral Infarction | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree,LHGDN |
| umls:C0014335 | Enteritis | 2 | BeFree |
| umls:C0019087 | Hemorrhagic Disorders | 2 | BeFree,GAD |
| umls:C0020443 | Hypercholesterolemia | 2 | GAD,LHGDN |
| umls:C0021368 | Inflammation | 2 | GAD,LHGDN |
| umls:C0025303 | Meningococcal Infections | 2 | BeFree |
| umls:C0025306 | Meningococcemia | 2 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 2 | GAD,LHGDN |
| umls:C0034065 | Pulmonary Embolism | 2 | BeFree,LHGDN |
| umls:C0085278 | Antiphospholipid Syndrome | 2 | BeFree |
| umls:C0085409 | Polyendocrinopathies, Autoimmune | 2 | BeFree |
| umls:C0151945 | Thrombosis of cerebral veins | 2 | BeFree |
| umls:C0578159 | Antibiotic-associated diarrhea | 2 | BeFree |
| umls:C0584960 | Factor V Leiden mutation | 2 | BeFree |
| umls:C1861172 | Venous Thromboembolism | 2 | LHGDN |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0000809 | Abortion, Habitual | 1 | GAD |
| umls:C0001349 | Acute-Phase Reaction | 1 | LHGDN |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0002453 | Amenorrhea | 1 | CTD_human |
| umls:C0002962 | Angina Pectoris | 1 | GAD |
| umls:C0002965 | Angina, Unstable | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | LHGDN |
| umls:C0004610 | Bacteremia | 1 | RGD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0012739 | Disseminated Intravascular Coagulation | 1 | BeFree,LHGDN |
| umls:C0013537 | Eclampsia | 1 | BeFree |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | RGD |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0019080 | Hemorrhage | 1 | GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0020550 | Hyperthyroidism | 1 | LHGDN |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0026766 | Multiple Organ Failure | 1 | RGD |
| umls:C0028754 | Obesity | 1 | CTD_human |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032045 | Placenta Disorders | 1 | GAD |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | LHGDN |
| umls:C0032914 | Pre-Eclampsia | 1 | LHGDN |
| umls:C0035328 | Retinal Vein Occlusion | 1 | BeFree |
| umls:C0036983 | Septic Shock | 1 | LHGDN |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
| umls:C0039240 | Supraventricular tachycardia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0042487 | Venous Thrombosis | 1 | GAD |
| umls:C0043407 | Yersinia infections | 1 | BeFree |
| umls:C0085298 | Sudden Cardiac Death | 1 | GAD |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0162869 | Aneurysm, Ruptured | 1 | GAD |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0262584 | Carcinoma, Small Cell | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
| umls:C0524702 | Pulmonary Thromboembolisms | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 1 | BeFree |
| umls:C0600433 | Activated Protein C Resistance | 1 | BeFree,LHGDN |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0687675 | Pregnancy loss | 1 | GAD |
| umls:C0836924 | Thrombocytosis | 1 | LHGDN |
| umls:C0852949 | Arteriopathic disease | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | RGD |
| umls:C0947751 | Vascular inflammations | 1 | BeFree |
| umls:C0948441 | Venoocclusive disease | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree,GAD |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1273976 | First myocardial infarction | 1 | BeFree |
| umls:C1531624 | Cardioembolic stroke | 1 | BeFree |
| umls:C1867596 | Hyperprothrombinemia | 1 | BeFree |
| umls:C2584409 | Prothrombin G20210A mutation | 1 | BeFree |
| umls:C2717961 | Thrombotic Microangiopathies | 1 | BeFree |
| umls:C3495426 | Homocysteinemia | 1 | BeFree |
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