TissGeneSummary for C7orf31 |
Gene summary |
Basic gene information | Gene symbol | C7orf31 |
Gene name | chromosome 7 open reading frame 31 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7p15.3 | |
Type of gene | protein-coding | |
RefGenes | NM_138811.3, | |
Description | uncharacterized protein C7orf31 | |
Modification date | 20141207 | |
dbXrefs | MIM : 616071 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153790 | ||
HPRD : 12919 | ||
Vega : OTTHUMG00000128497 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C7orf31 | |
BioGPS: 136895 | ||
Pathway | NCI Pathway Interaction Database: C7orf31 | |
KEGG: C7orf31 | ||
REACTOME: C7orf31 | ||
Pathway Commons: C7orf31 | ||
Context | iHOP: C7orf31 | |
ligand binding site mutation search in PubMed: C7orf31 | ||
UCL Cancer Institute: C7orf31 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C7orf31 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for C7orf31 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.089843249 | 0.951798856 | -1.041642105 | 1.23E-19 | 8.45E-19 |
PRAD | -0.630948647 | 0.525266737 | -1.156215385 | 5.15E-15 | 6.41E-13 |
COAD | 0.225339814 | 2.03102443 | -1.805684615 | 1.99E-10 | 2.61E-09 |
Top |
TissGene-miRNA for C7orf31 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for C7orf31 |
TissGeneSNV for C7orf31 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R556H | PRAD | 1 |
p.E100X | COAD | 1 |
p.R337* | LGG | 1 |
p.L562I | UCEC | 1 |
p.Q34H | HNSC | 1 |
p.A249P | ACC | 1 |
p.E76K | BLCA | 1 |
p.A189T | SKCM | 1 |
p.A158T | COAD | 1 |
p.S253C | LUAD | 1 |
p.R50M | LUAD | 1 |
p.D121N | BLCA | 1 |
p.R45M | COAD | 1 |
p.S574L | SKCM | 1 |
p.P361S | SKCM | 1 |
p.G333E | HNSC | 1 |
p.L288M | PAAD | 1 |
p.T286A | THYM | 1 |
p.P290S | BLCA | 1 |
p.Q340H | STAD | 1 |
p.S560L | HNSC | 1 |
p.S165P | STAD | 1 |
p.R556C | PAAD | 1 |
p.R38H | LUSC | 1 |
p.R556H | UCEC | 1 |
p.R337Q | UCEC | 1 |
p.R337X | SKCM | 1 |
p.V225L | SARC | 1 |
p.L307S | UCEC | 1 |
p.P130S | UCEC | 1 |
p.P244H | UCEC | 1 |
p.P71Q | READ | 1 |
p.P59S | STAD | 1 |
p.H463N | COAD | 1 |
p.L272I | UCEC | 1 |
p.S355F | SKCM | 1 |
p.R270I | UCEC | 1 |
p.T279A | PRAD | 1 |
p.Y82C | COAD | 1 |
p.K243N | KIRP | 1 |
p.S280L | GBM | 1 |
p.H153Y | LUAD | 1 |
p.S256L | SKCM | 1 |
p.A249T | COAD | 1 |
p.R337* | SKCM | 1 |
p.P39L | COAD | 1 |
p.P183S | SKCM | 1 |
p.T369A | LUSC | 1 |
p.R354C | CESC | 1 |
p.T164M | COAD | 1 |
p.R309Q | SKCM | 1 |
p.L33I | COAD | 1 |
p.E401G | BRCA | 1 |
p.L471I | PRAD | 1 |
p.D425E | COAD | 1 |
p.W257R | SKCM | 1 |
p.R156C | STAD | 1 |
p.W443C | BLCA | 1 |
p.D564E | UCEC | 1 |
p.M516I | LUAD | 1 |
p.E234Q | SKCM | 1 |
p.P161H | PRAD | 1 |
p.P487S | UCEC | 1 |
p.I529V | LUAD | 1 |
Top |
TissGeneCNV for C7orf31 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for C7orf31 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA751840 | C7orf31-RARS2 | chr7:25219914 | chr6:88272426 | |
Chimerdb3.0 | ChiTaRs | NA | BP262829 | RPS3-C7orf31 | chr11:75113427 | chr7:25219619 |
Top |
TissGeneNet for C7orf31 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for C7orf31 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for C7orf31 |
TissGeneDrug for C7orf31 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for C7orf31 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |