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| TissGeneSummary for CPN2 |
 Gene summary |
| Basic gene information | Gene symbol | CPN2 |
| Gene name | carboxypeptidase N, polypeptide 2 | |
| Synonyms | ACBP | |
| Cytomap | UCSC genome browser: 3q29 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001309.1, NM_001080513.3,NM_001291988.1, | |
| Description | arginine carboxypeptidasecarboxypeptidase N 83 kDa chaincarboxypeptidase N large subunitcarboxypeptidase N regulatory subunitcarboxypeptidase N subunit 2carboxypeptidase N, polypeptide 2, 83kD | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603104 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000178772 | ||
| HPRD : 11928 | ||
| Vega : OTTHUMG00000156047 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPN2 | |
| BioGPS: 1370 | ||
| Pathway | NCI Pathway Interaction Database: CPN2 | |
| KEGG: CPN2 | ||
| REACTOME: CPN2 | ||
| Pathway Commons: CPN2 | ||
| Context | iHOP: CPN2 | |
| ligand binding site mutation search in PubMed: CPN2 | ||
| UCL Cancer Institute: CPN2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CPN2 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CPN2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.067947052 | 3.340478996 | -3.272531944 | 1.43E-08 | 4.27E-08 |
| KICH | -2.867011671 | 2.275012329 | -5.142024 | 6.80E-09 | 3.75E-08 |
| KIRP | -0.775990796 | 4.227402954 | -5.00339375 | 3.82E-08 | 2.56E-07 |
| LIHC | 8.749416329 | 10.38828233 | -1.638866 | 3.10E-06 | 1.50E-05 |
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| TissGene-miRNA for CPN2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CPN2 |
| TissGeneSNV for CPN2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.H298Y | PRAD | 1 |
| p.E474K | SARC | 1 |
| p.D460E | CESC | 1 |
| p.R278W | SKCM | 1 |
| p.L356F | SKCM | 1 |
| p.S507F | SKCM | 1 |
| p.S520C | BLCA | 1 |
| p.L164F | SKCM | 1 |
| p.Q412K | KIRP | 1 |
| p.S346G | LUSC | 1 |
| p.A204V | UCEC | 1 |
| p.P137S | UCEC | 1 |
| p.L224M | UCEC | 1 |
| p.E65K | HNSC | 1 |
| p.R449W | GBM | 1 |
| p.P545S | GBM | 1 |
| p.Q153R | STAD | 1 |
| p.L198Q | BRCA | 1 |
| p.P48Q | LUAD | 1 |
| p.E461K | SKCM | 1 |
| p.T326A | UCEC | 1 |
| p.V212L | LUAD | 1 |
| p.T169A | COAD | 1 |
| p.Q183* | SKCM | 1 |
| p.V292A | LIHC | 1 |
| p.Q421* | SKCM | 1 |
| p.T254K | LUAD | 1 |
| p.S149F | SKCM | 1 |
| p.E302K | SKCM | 1 |
| p.A310D | LUAD | 1 |
| p.V447I | LUSC | 1 |
| p.P161A | HNSC | 1 |
| p.V30I | COAD | 1 |
| p.P185Q | LUAD | 1 |
| p.T374A | UCEC | 1 |
| p.A204S | BLCA | 1 |
| p.R250H | STAD | 1 |
| p.W523* | SKCM | 1 |
| p.S528T | BLCA | 1 |
| p.R316C | HNSC | 1 |
| p.Q421X | SKCM | 1 |
| p.P209S | SKCM | 1 |
| p.P329L | SKCM | 1 |
| p.F61L | SKCM | 1 |
| p.T114I | COAD | 1 |
| p.E138Q | HNSC | 1 |
| p.F165V | UCEC | 1 |
| p.R449Q | STAD | 1 |
| p.P44L | STAD | 1 |
| p.S484I | PAAD | 1 |
| p.A204V | DLBC | 1 |
| p.W523X | SKCM | 1 |
| p.L243Q | LUAD | 1 |
| p.S467I | KIRP | 1 |
| p.G217C | OV | 1 |
| p.E58K | SARC | 1 |
| p.E378K | BLCA | 1 |
| p.T254K | TGCT | 1 |
| p.S317F | SKCM | 1 |
| p.S512F | SKCM | 1 |
| p.L144M | STAD | 1 |
| p.L246M | UCEC | 1 |
| p.I538V | UCEC | 1 |
| p.W468R | OV | 1 |
| p.P354S | PAAD | 1 |
| p.T482I | SKCM | 1 |
| p.T350K | LUAD | 1 |
| p.I325V | BLCA | 1 |
| p.P90L | BLCA | 1 |
| p.Q87L | LUAD | 1 |
| p.E474D | BLCA | 1 |
| p.S60L | SKCM | 1 |
| p.D101N | SKCM | 1 |
| p.P234R | LUAD | 1 |
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| TissGeneCNV for CPN2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CPN2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CPN2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CPN2, CUL3, CUL1, CPN1 (tumor) | CPN2, CUL3, CUL1, CPN1 (normal) |
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| TissGeneProg for CPN2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CPN2 |
| TissGeneDrug for CPN2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CPN2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007112 | Adenocarcinoma of prostate | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
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