TissGeneSummary for DCAF4L2 |
Gene summary |
Basic gene information | Gene symbol | DCAF4L2 |
Gene name | DDB1 and CUL4 associated factor 4-like 2 | |
Synonyms | WDR21C | |
Cytomap | UCSC genome browser: 8q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_152418.3, | |
Description | DDB1- and CUL4-associated factor 4-like protein 2WD repeat domain 21CWD repeat-containing protein 21C | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000176566 | ||
HPRD : 08187 | ||
Vega : OTTHUMG00000163767 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCAF4L2 | |
BioGPS: 138009 | ||
Pathway | NCI Pathway Interaction Database: DCAF4L2 | |
KEGG: DCAF4L2 | ||
REACTOME: DCAF4L2 | ||
Pathway Commons: DCAF4L2 | ||
Context | iHOP: DCAF4L2 | |
ligand binding site mutation search in PubMed: DCAF4L2 | ||
UCL Cancer Institute: DCAF4L2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DCAF4L2 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DCAF4L2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 1.475387039 | -2.236070961 | 3.711458 | 9.10E-07 | 4.87E-06 |
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TissGene-miRNA for DCAF4L2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DCAF4L2 |
TissGeneSNV for DCAF4L2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E309K | SKCM | 3 |
p.R386Q | SKCM | 2 |
p.R386Q | COAD | 2 |
p.R344L | LUAD | 2 |
p.R76H | STAD | 2 |
p.A133V | SKCM | 2 |
p.D65N | SKCM | 2 |
p.P116Q | LUAD | 2 |
p.R172C | COAD | 1 |
p.P110L | SKCM | 1 |
p.A378E | ACC | 1 |
p.S369Y | LUAD | 1 |
p.R371H | UCEC | 1 |
p.G346S | STAD | 1 |
p.R113W | LUSC | 1 |
p.C43F | LUAD | 1 |
p.R47C | SKCM | 1 |
p.V332L | LUAD | 1 |
p.G22* | LUAD | 1 |
p.T103N | LUAD | 1 |
p.P123S | SKCM | 1 |
p.E324* | BLCA | 1 |
p.Q219R | UCEC | 1 |
p.P169S | COAD | 1 |
p.A378S | LUAD | 1 |
p.K17N | HNSC | 1 |
p.E48K | SKCM | 1 |
p.R76H | UCEC | 1 |
p.A358T | PRAD | 1 |
p.R339G | SKCM | 1 |
p.Q60X | SKCM | 1 |
p.F146L | ESCA | 1 |
p.R56S | LUAD | 1 |
p.L177I | LUAD | 1 |
p.A316T | SARC | 1 |
p.N82Y | LUAD | 1 |
p.D252N | LUAD | 1 |
p.V122I | PRAD | 1 |
p.H137Y | SKCM | 1 |
p.E111G | STAD | 1 |
p.H195Q | LUAD | 1 |
p.S129F | SKCM | 1 |
p.L372I | LUAD | 1 |
p.S260R | COAD | 1 |
p.S3I | LUAD | 1 |
p.D72N | SARC | 1 |
p.T338M | READ | 1 |
p.R47H | UCEC | 1 |
p.A196V | LUAD | 1 |
p.G100V | LUAD | 1 |
p.R386W | CESC | 1 |
p.G250D | READ | 1 |
p.M176I | LUAD | 1 |
p.R50S | HNSC | 1 |
p.P110T | COAD | 1 |
p.E93K | SKCM | 1 |
p.Q60* | SKCM | 1 |
p.A40T | BLCA | 1 |
p.S154R | LGG | 1 |
p.R38K | BRCA | 1 |
p.A161P | COAD | 1 |
p.G256E | SKCM | 1 |
p.Q181K | BRCA | 1 |
p.R371H | PRAD | 1 |
p.R73Q | SKCM | 1 |
p.A196V | BLCA | 1 |
p.K295N | BLCA | 1 |
p.S354F | SKCM | 1 |
p.T306P | LUAD | 1 |
p.A40S | HNSC | 1 |
p.Q283L | LIHC | 1 |
p.L372F | SKCM | 1 |
p.G259C | LUAD | 1 |
p.L159P | STAD | 1 |
p.D72E | LUAD | 1 |
p.L296P | LIHC | 1 |
p.L9I | HNSC | 1 |
p.R50C | COAD | 1 |
p.S134* | LUAD | 1 |
p.E48G | COAD | 1 |
p.G166S | SKCM | 1 |
p.R339K | SKCM | 1 |
p.T83I | LUAD | 1 |
p.S205P | BLCA | 1 |
p.D13N | SKCM | 1 |
p.R76L | LUAD | 1 |
p.P66S | SKCM | 1 |
p.G22R | SKCM | 1 |
p.A316T | STAD | 1 |
p.A330V | BRCA | 1 |
p.V329M | BRCA | 1 |
p.A196V | PRAD | 1 |
p.H62Y | HNSC | 1 |
p.R376Q | PRAD | 1 |
p.P123T | LUAD | 1 |
p.K17N | STAD | 1 |
p.L299V | STAD | 1 |
p.G292V | UCEC | 1 |
p.S315F | DLBC | 1 |
p.M1I | LUAD | 1 |
p.K4R | LUAD | 1 |
p.S167R | LUAD | 1 |
p.R339I | UCEC | 1 |
p.W262* | LUAD | 1 |
p.P364L | SKCM | 1 |
p.R7P | HNSC | 1 |
p.A196S | LUSC | 1 |
p.P357L | SKCM | 1 |
p.G35C | LUSC | 1 |
p.P237S | COAD | 1 |
p.G222W | LUAD | 1 |
p.R38S | BLCA | 1 |
p.G100D | LUAD | 1 |
p.R125W | UCEC | 1 |
p.R172H | HNSC | 1 |
p.V329M | UCEC | 1 |
p.S129Y | COAD | 1 |
p.Q230R | LUSC | 1 |
p.P183S | CESC | 1 |
p.R376* | BLCA | 1 |
p.S52C | GBM | 1 |
p.V366M | HNSC | 1 |
p.V320L | LUAD | 1 |
p.A150P | OV | 1 |
p.Y115* | LUAD | 1 |
p.A79V | UCEC | 1 |
p.L135P | LUAD | 1 |
p.Q206* | BLCA | 1 |
p.R125W | SKCM | 1 |
p.R125W | LUAD | 1 |
p.R244C | SKCM | 1 |
p.G346D | SKCM | 1 |
p.S162L | SKCM | 1 |
p.T215M | READ | 1 |
p.A358T | LGG | 1 |
p.S129T | SKCM | 1 |
p.V147L | LUAD | 1 |
p.C255* | LUAD | 1 |
p.E11K | SKCM | 1 |
p.G96V | LUAD | 1 |
p.L135M | LUAD | 1 |
p.G100D | STAD | 1 |
p.S260R | LUAD | 1 |
p.F392L | BLCA | 1 |
p.P6L | CHOL | 1 |
p.R244H | UCEC | 1 |
p.H62Y | LIHC | 1 |
p.S224I | UCEC | 1 |
p.R254C | COAD | 1 |
p.R244H | READ | 1 |
p.R254H | CESC | 1 |
p.T103N | UCEC | 1 |
p.R254H | COAD | 1 |
p.F232S | UCEC | 1 |
p.R254C | BRCA | 1 |
p.D298Y | READ | 1 |
p.A331V | LUSC | 1 |
p.R50C | LUAD | 1 |
p.C255S | LUAD | 1 |
p.L78P | LUSC | 1 |
p.H137Q | PAAD | 1 |
p.S140F | SKCM | 1 |
p.M54V | PRAD | 1 |
p.S162* | LUSC | 1 |
p.R56M | HNSC | 1 |
p.G327E | BRCA | 1 |
p.T152N | LUAD | 1 |
p.A330S | BLCA | 1 |
p.V147L | LUSC | 1 |
p.L142F | LUSC | 1 |
p.S365I | HNSC | 1 |
p.Y99H | STAD | 1 |
p.R172H | COAD | 1 |
p.D362N | SKCM | 1 |
p.D362Y | LUSC | 1 |
p.T302I | HNSC | 1 |
p.E93D | STAD | 1 |
p.M235T | STAD | 1 |
p.P379L | SKCM | 1 |
p.V157M | LUAD | 1 |
p.C243Y | HNSC | 1 |
p.P153Q | LUSC | 1 |
p.Q334K | LUAD | 1 |
p.S134X | ESCA | 1 |
p.L138F | LUAD | 1 |
p.V320M | BRCA | 1 |
p.C131X | READ | 1 |
p.R113W | COAD | 1 |
p.E111Q | KIRP | 1 |
p.Q334E | LGG | 1 |
p.R172C | UCEC | 1 |
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TissGeneCNV for DCAF4L2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DCAF4L2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for DCAF4L2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DCAF4L2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DCAF4L2 |
TissGeneDrug for DCAF4L2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DCAF4L2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |