 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for RNF183 |
 Gene summary |
| Basic gene information | Gene symbol | RNF183 |
| Gene name | ring finger protein 183 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 9q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_145051.3, | |
| Description | RING finger protein 183 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000165188 | ||
| HPRD : 10082 | ||
| Vega : OTTHUMG00000020520 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RNF183 | |
| BioGPS: 138065 | ||
| Pathway | NCI Pathway Interaction Database: RNF183 | |
| KEGG: RNF183 | ||
| REACTOME: RNF183 | ||
| Pathway Commons: RNF183 | ||
| Context | iHOP: RNF183 | |
| ligand binding site mutation search in PubMed: RNF183 | ||
| UCL Cancer Institute: RNF183 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUCEC,UCS | |
| Reference showing the relevant tissue of RNF183 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for RNF183 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 1.928889088 | -0.798660912 | 2.72755 | 6.14E-11 | 9.09E-10 |
| KICH | -2.893877066 | 0.872142934 | -3.76602 | 1.49E-08 | 7.69E-08 |
| THCA | 0.497897171 | -1.966374015 | 2.464271186 | 7.32E-12 | 5.69E-11 |
| HNSC | -1.882552415 | 0.272575492 | -2.155127907 | 5.73E-07 | 4.62E-06 |
| LUAD | -0.109431204 | -2.266146721 | 2.156715517 | 3.09E-08 | 1.30E-07 |
| LUSC | -0.957353144 | -2.223655105 | 1.266301961 | 0.000418 | 0.000819979 |
| BRCA | -0.464509698 | 0.652635917 | -1.117145614 | 6.87E-05 | 0.000156099 |
| Top |
| TissGene-miRNA for RNF183 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for RNF183 |
| TissGeneSNV for RNF183 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P130L | BRCA | 1 |
| p.R156C | SKCM | 1 |
| p.F36V | SKCM | 1 |
| p.Q114R | COAD | 1 |
| p.S67L | SKCM | 1 |
| p.V173I | SARC | 1 |
| p.G95V | BLCA | 1 |
| p.L65M | LUAD | 1 |
| p.A82T | COAD | 1 |
| p.R51W | STAD | 1 |
| p.T141M | ACC | 1 |
| Top |
| TissGeneCNV for RNF183 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for RNF183 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for RNF183 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| RNF183, FBP1, EWSR1, IFFO1, FATE1 (tumor) | RNF183, FBP1, EWSR1, IFFO1, FATE1 (normal) |
 |  |
| Top |
| TissGeneProg for RNF183 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for RNF183 |
| TissGeneDrug for RNF183 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for RNF183 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |