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| TissGeneSummary for CRABP2 |
 Gene summary |
| Basic gene information | Gene symbol | CRABP2 |
| Gene name | cellular retinoic acid binding protein 2 | |
| Synonyms | CRABP-II|RBP6 | |
| Cytomap | UCSC genome browser: 1q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199723.1, NM_001878.3, | |
| Description | cellular retinoic acid-binding protein 2cellular retinoic acid-binding protein II | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 180231 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143320 | ||
| HPRD : 08353 | ||
| Vega : OTTHUMG00000041300 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CRABP2 | |
| BioGPS: 1382 | ||
| Pathway | NCI Pathway Interaction Database: CRABP2 | |
| KEGG: CRABP2 | ||
| REACTOME: CRABP2 | ||
| Pathway Commons: CRABP2 | ||
| Context | iHOP: CRABP2 | |
| ligand binding site mutation search in PubMed: CRABP2 | ||
| UCL Cancer Institute: CRABP2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAUVM | |
| Reference showing the relevant tissue of CRABP2 | ||
| Description by TissGene annotations | Risk TissGene in OS Risk TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CRABP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -5.535611985 | -2.336820318 | -3.198791667 | 6.69E-25 | 7.97E-24 |
| BRCA | 3.44939262 | 1.878443497 | 1.570949123 | 1.55E-13 | 7.29E-13 |
| THCA | 0.913053057 | -0.784358807 | 1.697411864 | 1.04E-10 | 6.91E-10 |
| KICH | -6.192931485 | -1.994259485 | -4.198672 | 4.66E-13 | 5.90E-12 |
| LUSC | 0.769424044 | -2.989344583 | 3.758768627 | 2.96E-21 | 4.11E-20 |
| LUAD | 1.537500515 | -3.273249485 | 4.81075 | 4.76E-24 | 1.81E-22 |
| KIRP | -4.615324485 | -2.287011985 | -2.3283125 | 1.76E-08 | 1.29E-07 |
| PRAD | -1.458943716 | 0.679294746 | -2.138238462 | 4.56E-11 | 1.12E-09 |
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| TissGene-miRNA for CRABP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CRABP2 |
| TissGeneSNV for CRABP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R60H | UCEC | 2 |
| p.G105S | BLCA | 1 |
| p.D117N | PRAD | 1 |
| p.E104* | LUSC | 1 |
| p.M94T | LUAD | 1 |
| p.E119K | LUAD | 1 |
| p.Q75X | STAD | 1 |
| p.K31M | LIHC | 1 |
| p.C96S | LUAD | 1 |
| p.L20F | STAD | 1 |
| p.V59L | SKCM | 1 |
| p.E47V | HNSC | 1 |
| p.Q75* | STAD | 1 |
| p.R60H | HNSC | 1 |
| p.R12Q | LUSC | 1 |
| p.S109W | BLCA | 1 |
| p.R60C | LUAD | 1 |
| p.D117N | SKCM | 1 |
| p.S109L | BLCA | 1 |
| p.E17D | UCEC | 1 |
| p.E18D | STAD | 1 |
| p.A33D | UCEC | 1 |
| p.E138Q | READ | 1 |
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| TissGeneCNV for CRABP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CRABP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CRABP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| COAD (tumor) | COAD (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| KICH (tumor) | KICH (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| STAD (tumor) | STAD (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| THCA (tumor) | THCA (normal) |
| CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (tumor) | CRABP2, UBC, SUMO2, RARA, PAX3, UBE2I, SUMO3, CCND3 (normal) |
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| TissGeneProg for CRABP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CRABP2 |
| TissGeneDrug for CRABP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CRABP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0027819 | Neuroblastoma | 3 | BeFree |
| umls:C0700095 | Central neuroblastoma | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree,LHGDN |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0023267 | Fibroid Tumor | 1 | BeFree |
| umls:C0023787 | Lipodystrophy | 1 | LHGDN |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0027533 | Neck Neoplasms | 1 | BeFree |
| umls:C0027708 | Nephroblastoma | 1 | BeFree |
| umls:C0027794 | Neural Tube Defects | 1 | GAD |
| umls:C0041834 | Erythema | 1 | BeFree |
| umls:C0042133 | Uterine Fibroids | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0154251 | Lipid Metabolism Disorders | 1 | BeFree |
| umls:C0220989 | Acquired partial lipodystrophy | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0268583 | Methylmalonic acidemia | 1 | CTD_human |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1846431 | SMITH-MCCORT DYSPLASIA | 1 | BeFree |
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