TissGeneSummary for BEND2 |
Gene summary |
Basic gene information | Gene symbol | BEND2 |
Gene name | BEN domain containing 2 | |
Synonyms | CXorf20 | |
Cytomap | UCSC genome browser: Xp22.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001184767.1, NM_153346.4, | |
Description | BEN domain-containing protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000177324 | ||
HPRD : 06646 | ||
Vega : OTTHUMG00000021211 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BEND2 | |
BioGPS: 139105 | ||
Pathway | NCI Pathway Interaction Database: BEND2 | |
KEGG: BEND2 | ||
REACTOME: BEND2 | ||
Pathway Commons: BEND2 | ||
Context | iHOP: BEND2 | |
ligand binding site mutation search in PubMed: BEND2 | ||
UCL Cancer Institute: BEND2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of BEND2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for BEND2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.292379395 | -0.006197042 | -1.286182353 | 7.63E-15 | 4.58E-14 |
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TissGene-miRNA for BEND2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BEND2 |
TissGeneSNV for BEND2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E199K | SKCM | 2 |
p.P792S | SKCM | 2 |
p.E517K | SKCM | 2 |
p.P209S | SKCM | 2 |
p.S146T | LUSC | 1 |
p.I520T | UCEC | 1 |
p.E630* | STAD | 1 |
p.I13V | LUAD | 1 |
p.R646* | UCEC | 1 |
p.S706C | LUSC | 1 |
p.A241G | BRCA | 1 |
p.T650N | HNSC | 1 |
p.H527Y | SKCM | 1 |
p.I670K | LUAD | 1 |
p.D764N | HNSC | 1 |
p.V140A | COAD | 1 |
p.E30D | THCA | 1 |
p.P305T | SKCM | 1 |
p.A640P | LUAD | 1 |
p.F230C | ESCA | 1 |
p.E317K | HNSC | 1 |
p.R264L | LUAD | 1 |
p.S215R | STAD | 1 |
p.S617Y | UCEC | 1 |
p.Q695X | ESCA | 1 |
p.G70D | UCEC | 1 |
p.S638N | SKCM | 1 |
p.F160L | UCS | 1 |
p.I136T | STAD | 1 |
p.S469C | BLCA | 1 |
p.L509F | LUAD | 1 |
p.G66V | LUAD | 1 |
p.G612V | LUAD | 1 |
p.L302V | UCEC | 1 |
p.P65S | SKCM | 1 |
p.S774L | LGG | 1 |
p.H71N | COAD | 1 |
p.S422F | BLCA | 1 |
p.S38C | BLCA | 1 |
p.S78* | UCEC | 1 |
p.T162I | SKCM | 1 |
p.H299N | HNSC | 1 |
p.G402R | SKCM | 1 |
p.G158E | SKCM | 1 |
p.V338L | KIRC | 1 |
p.R646P | PAAD | 1 |
p.V49I | OV | 1 |
p.R264Q | SKCM | 1 |
p.P482S | HNSC | 1 |
p.S335Y | UCEC | 1 |
p.N21K | OV | 1 |
p.S461I | LUAD | 1 |
p.A547E | LUAD | 1 |
p.R484I | READ | 1 |
p.P155S | SKCM | 1 |
p.G559E | SKCM | 1 |
p.L740I | LUSC | 1 |
p.P139Q | COAD | 1 |
p.Q695* | ESCA | 1 |
p.Y147C | LUAD | 1 |
p.E786* | SKCM | 1 |
p.S578Y | COAD | 1 |
p.V448I | STAD | 1 |
p.G67D | LGG | 1 |
p.S571F | UCEC | 1 |
p.N286D | BLCA | 1 |
p.L432S | LUSC | 1 |
p.R511C | UCEC | 1 |
p.A600V | LUAD | 1 |
p.R646X | COAD | 1 |
p.P721H | LUSC | 1 |
p.P789L | LUAD | 1 |
p.R73H | BLCA | 1 |
p.R4T | SKCM | 1 |
p.E33K | SKCM | 1 |
p.D791H | HNSC | 1 |
p.N40Y | BRCA | 1 |
p.R484K | COAD | 1 |
p.Q366H | UCEC | 1 |
p.Y161C | LUAD | 1 |
p.R511H | LGG | 1 |
p.T323A | ESCA | 1 |
p.G609S | SKCM | 1 |
p.T594I | UCEC | 1 |
p.I237V | HNSC | 1 |
p.R759C | PAAD | 1 |
p.L727F | HNSC | 1 |
p.A292D | LGG | 1 |
p.G231D | SKCM | 1 |
p.A640V | SKCM | 1 |
p.S38F | BLCA | 1 |
p.M619I | SKCM | 1 |
p.P584T | LUAD | 1 |
p.G375E | HNSC | 1 |
p.A500V | HNSC | 1 |
p.R728X | COAD | 1 |
p.P721L | SKCM | 1 |
p.P305S | HNSC | 1 |
p.S661R | UCEC | 1 |
p.L783Q | LIHC | 1 |
p.S638R | SKCM | 1 |
p.G402E | PAAD | 1 |
p.D23N | SKCM | 1 |
p.A292T | SKCM | 1 |
p.P289T | HNSC | 1 |
p.N722K | SARC | 1 |
p.E654K | SKCM | 1 |
p.E164Q | BLCA | 1 |
p.A51T | LGG | 1 |
p.N633K | COAD | 1 |
p.F154L | COAD | 1 |
p.E786X | SKCM | 1 |
p.S787* | LUAD | 1 |
p.M672I | UCEC | 1 |
p.S661_splice | UCEC | 1 |
p.N53T | STAD | 1 |
p.T377K | LUAD | 1 |
p.D415Y | STAD | 1 |
p.P139T | LUAD | 1 |
p.R264* | OV | 1 |
p.V708L | UCEC | 1 |
p.K347R | SKCM | 1 |
p.E630X | STAD | 1 |
p.A768P | CESC | 1 |
p.T594I | LUAD | 1 |
p.G225A | LUAD | 1 |
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TissGeneCNV for BEND2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BEND2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for BEND2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BEND2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BEND2 |
TissGeneDrug for BEND2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BEND2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C3495559 | Juvenile arthritis | 1 | CTD_human |