TissGeneSummary for MAGEB10 |
Gene summary |
Basic gene information | Gene symbol | MAGEB10 |
Gene name | melanoma antigen family B, 10 | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xp21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_182506.3, | |
Description | MAGE family testis and tumor-specific proteinMAGE-B10 antigenmelanoma-associated antigen B10 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300761 | |
HGNC : HGNC | ||
Ensembl : ENSG00000177689 | ||
HPRD : 06554 | ||
Vega : OTTHUMG00000046084 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEB10 | |
BioGPS: 139422 | ||
Pathway | NCI Pathway Interaction Database: MAGEB10 | |
KEGG: MAGEB10 | ||
REACTOME: MAGEB10 | ||
Pathway Commons: MAGEB10 | ||
Context | iHOP: MAGEB10 | |
ligand binding site mutation search in PubMed: MAGEB10 | ||
UCL Cancer Institute: MAGEB10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MAGEB10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for MAGEB10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for MAGEB10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-130a-5p | MIMAT0004593 | 0.012 | -0.29 | 78 |
ACC | hsa-miR-130a-5p | MIMAT0004593 | 0.012 | -0.29 | 78 |
Top |
TissGeneMut for MAGEB10 |
TissGeneSNV for MAGEB10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M128I | SKCM | 1 |
p.E13D | DLBC | 1 |
p.E130* | UCEC | 1 |
p.A102T | UCEC | 1 |
p.T142A | LIHC | 1 |
p.K129N | STAD | 1 |
p.R3* | BLCA | 1 |
p.P277T | UCEC | 1 |
p.E33K | UCEC | 1 |
p.R335C | STAD | 1 |
p.F303L | UCEC | 1 |
p.D48G | THCA | 1 |
p.G109V | PAAD | 1 |
p.D185G | LUSC | 1 |
p.D167Y | UCEC | 1 |
p.E23K | BLCA | 1 |
p.E113K | SKCM | 1 |
p.T201A | BLCA | 1 |
p.H238Y | CHOL | 1 |
p.D112G | UCEC | 1 |
p.L122M | LUAD | 1 |
p.R327C | SKCM | 1 |
p.D24N | SKCM | 1 |
p.Q5* | CESC | 1 |
p.K337* | LUAD | 1 |
p.G333S | KIRC | 1 |
p.N265K | STAD | 1 |
p.E243K | HNSC | 1 |
p.E255K | UCEC | 1 |
p.M286I | UCEC | 1 |
p.P39S | SKCM | 1 |
p.W275* | SKCM | 1 |
p.S38F | BRCA | 1 |
p.C217X | ESCA | 1 |
p.E37D | UCEC | 1 |
p.E243X | THYM | 1 |
p.K125N | UCEC | 1 |
p.F149Y | HNSC | 1 |
p.A18S | LUAD | 1 |
p.R16C | UCEC | 1 |
p.G235R | UCEC | 1 |
p.D24N | TGCT | 1 |
p.D136Y | LUAD | 1 |
p.R19L | BLCA | 1 |
p.E91K | CESC | 1 |
p.L292W | CESC | 1 |
p.H238N | KIRC | 1 |
p.P94L | UCEC | 1 |
p.E37K | SKCM | 1 |
p.K146M | LUAD | 1 |
p.G63E | SKCM | 1 |
p.Q261L | LUAD | 1 |
p.M286I | READ | 1 |
p.S38F | SKCM | 1 |
p.Q68K | LUAD | 1 |
p.P150S | SKCM | 1 |
p.R3G | BRCA | 1 |
p.E66K | BLCA | 1 |
p.L100R | READ | 1 |
p.S284R | ACC | 1 |
p.K8R | SKCM | 1 |
p.L232F | STAD | 1 |
p.W275X | SKCM | 1 |
p.C217* | ESCA | 1 |
p.D99Y | UCEC | 1 |
p.A324D | LUAD | 1 |
p.G85* | UCEC | 1 |
p.E315K | SKCM | 1 |
p.E13K | SKCM | 1 |
p.G242W | LUAD | 1 |
Top |
TissGeneCNV for MAGEB10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for MAGEB10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for MAGEB10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for MAGEB10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for MAGEB10 |
TissGeneDrug for MAGEB10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for MAGEB10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |