TissGeneSummary for OTUD6A |
Gene summary |
Basic gene information | Gene symbol | OTUD6A |
Gene name | OTU deubiquitinase 6A | |
Synonyms | DUBA2|HSHIN6 | |
Cytomap | UCSC genome browser: Xq13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_207320.1, | |
Description | DUBA-2HIN-6 proteaseOTU domain containing 6AOTU domain-containing protein 6A | |
Modification date | 20141207 | |
dbXrefs | MIM : 300714 | |
HGNC : HGNC | ||
Ensembl : ENSG00000189401 | ||
HPRD : 13681 | ||
Vega : OTTHUMG00000159996 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OTUD6A | |
BioGPS: 139562 | ||
Pathway | NCI Pathway Interaction Database: OTUD6A | |
KEGG: OTUD6A | ||
REACTOME: OTUD6A | ||
Pathway Commons: OTUD6A | ||
Context | iHOP: OTUD6A | |
ligand binding site mutation search in PubMed: OTUD6A | ||
UCL Cancer Institute: OTUD6A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OTUD6A | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0035523 | protein K29-linked deubiquitination | 23827681 | GO:0035871 | protein K11-linked deubiquitination | 23827681 | GO:1990167 | protein K27-linked deubiquitination | 23827681 | GO:1990168 | protein K33-linked deubiquitination | 23827681 | GO:0035523 | protein K29-linked deubiquitination | 23827681 | GO:0035871 | protein K11-linked deubiquitination | 23827681 | GO:1990167 | protein K27-linked deubiquitination | 23827681 | GO:1990168 | protein K33-linked deubiquitination | 23827681 |
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TissGeneExp for OTUD6A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for OTUD6A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OTUD6A |
TissGeneSNV for OTUD6A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E193K | SKCM | 2 |
p.M204I | SKCM | 2 |
p.P147L | HNSC | 1 |
p.R87W | UCEC | 1 |
p.L220P | LUAD | 1 |
p.R171H | COAD | 1 |
p.D69N | SKCM | 1 |
p.R171L | ACC | 1 |
p.A279V | SKCM | 1 |
p.L222Q | LUAD | 1 |
p.R50H | COAD | 1 |
p.E128V | BLCA | 1 |
p.E184* | LUSC | 1 |
p.R173H | LGG | 1 |
p.E116Q | CESC | 1 |
p.R90H | LUAD | 1 |
p.E105K | SKCM | 1 |
p.P192T | LUAD | 1 |
p.S176G | LUAD | 1 |
p.E234K | SKCM | 1 |
p.V211M | UCEC | 1 |
p.P232H | LUAD | 1 |
p.A280S | LUAD | 1 |
p.L12V | BLCA | 1 |
p.D239Y | ESCA | 1 |
p.R100X | STAD | 1 |
p.D37N | LUAD | 1 |
p.V211L | THCA | 1 |
p.R171P | BLCA | 1 |
p.E18K | BRCA | 1 |
p.E85K | SKCM | 1 |
p.T214M | BRCA | 1 |
p.Q158* | SKCM | 1 |
p.V250D | LUAD | 1 |
p.R100* | STAD | 1 |
p.E248K | SKCM | 1 |
p.G246R | SKCM | 1 |
p.E128Q | LUAD | 1 |
p.N270I | LUAD | 1 |
p.C207Y | UCEC | 1 |
p.V283M | STAD | 1 |
p.S28R | LUAD | 1 |
p.G246E | SKCM | 1 |
p.D37V | SARC | 1 |
p.R108H | COAD | 1 |
p.E276K | SKCM | 1 |
p.R212L | LUAD | 1 |
p.M204I | HNSC | 1 |
p.E104K | STAD | 1 |
p.A224V | SKCM | 1 |
p.V162M | SKCM | 1 |
p.T214M | STAD | 1 |
p.A115P | GBM | 1 |
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TissGeneCNV for OTUD6A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OTUD6A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OTUD6A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OTUD6A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OTUD6A |
TissGeneDrug for OTUD6A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OTUD6A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |