TissGeneSummary for FOXR2 |
Gene summary |
Basic gene information | Gene symbol | FOXR2 |
Gene name | forkhead box R2 | |
Synonyms | FOXN6 | |
Cytomap | UCSC genome browser: Xp11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_198451.3, | |
Description | forkhead box protein N6forkhead box protein R2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 13552 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FOXR2 | |
BioGPS: 139628 | ||
Pathway | NCI Pathway Interaction Database: FOXR2 | |
KEGG: FOXR2 | ||
REACTOME: FOXR2 | ||
Pathway Commons: FOXR2 | ||
Context | iHOP: FOXR2 | |
ligand binding site mutation search in PubMed: FOXR2 | ||
UCL Cancer Institute: FOXR2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FOXR2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FOXR2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FOXR2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FOXR2 |
TissGeneSNV for FOXR2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P109S | SKCM | 2 |
p.P140S | SKCM | 2 |
p.S134F | SKCM | 2 |
p.D261N | CESC | 1 |
p.G91C | STAD | 1 |
p.W230X | SKCM | 1 |
p.P98H | LUAD | 1 |
p.P233S | SKCM | 1 |
p.S135F | LIHC | 1 |
p.G100R | LUSC | 1 |
p.F309L | BLCA | 1 |
p.D261A | GBM | 1 |
p.E124K | SKCM | 1 |
p.E58* | UCEC | 1 |
p.R192K | SKCM | 1 |
p.D310N | SKCM | 1 |
p.P67T | UCS | 1 |
p.P132S | UCEC | 1 |
p.S66C | LUAD | 1 |
p.P302Q | LUAD | 1 |
p.E187Q | KIRC | 1 |
p.W230* | SKCM | 1 |
p.D7Y | UCEC | 1 |
p.K116* | SKCM | 1 |
p.E124K | BLCA | 1 |
p.D151N | HNSC | 1 |
p.W190* | LGG | 1 |
p.E118K | GBM | 1 |
p.N85S | UCEC | 1 |
p.E118K | SKCM | 1 |
p.P60T | LUAD | 1 |
p.H241Y | SKCM | 1 |
p.R63K | SKCM | 1 |
p.P76S | SKCM | 1 |
p.H210R | LIHC | 1 |
p.P57S | GBM | 1 |
p.Q178H | LUAD | 1 |
p.D164N | UCEC | 1 |
p.R192M | BRCA | 1 |
p.M299V | LUAD | 1 |
p.Q291* | BLCA | 1 |
p.R285C | GBM | 1 |
p.E156K | SKCM | 1 |
p.G212D | HNSC | 1 |
p.G119R | ESCA | 1 |
p.M299I | CESC | 1 |
p.Q178K | LUAD | 1 |
p.P162Q | LIHC | 1 |
p.I107M | COAD | 1 |
p.P109L | SKCM | 1 |
p.P132Q | STAD | 1 |
p.L30I | THCA | 1 |
p.A47V | PRAD | 1 |
p.D310H | BLCA | 1 |
p.S40Y | UCEC | 1 |
p.L269F | SKCM | 1 |
p.P227L | HNSC | 1 |
p.K4T | LGG | 1 |
p.W236L | LUAD | 1 |
p.N196T | STAD | 1 |
p.S189F | SKCM | 1 |
p.R223G | UCEC | 1 |
p.R63T | GBM | 1 |
p.P73L | SKCM | 1 |
p.D70H | CESC | 1 |
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TissGeneCNV for FOXR2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FOXR2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FOXR2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FOXR2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FOXR2 |
TissGeneDrug for FOXR2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FOXR2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0206727 | Nerve Sheath Tumors | 1 | CTD_human |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0751690 | Malignant Peripheral Nerve Sheath Tumor | 1 | BeFree |