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| TissGeneSummary for ACTRT1 |
 Gene summary |
| Basic gene information | Gene symbol | ACTRT1 |
| Gene name | actin-related protein T1 | |
| Synonyms | AIP1|ARIP1|ARPT1|HSD27 | |
| Cytomap | UCSC genome browser: Xq25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_138289.3, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300487 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123165 | ||
| HPRD : 06439 | ||
| Vega : OTTHUMG00000022359 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACTRT1 | |
| BioGPS: 139741 | ||
| Pathway | NCI Pathway Interaction Database: ACTRT1 | |
| KEGG: ACTRT1 | ||
| REACTOME: ACTRT1 | ||
| Pathway Commons: ACTRT1 | ||
| Context | iHOP: ACTRT1 | |
| ligand binding site mutation search in PubMed: ACTRT1 | ||
| UCL Cancer Institute: ACTRT1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ACTRT1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ACTRT1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ACTRT1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ACTRT1 |
| TissGeneSNV for ACTRT1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E117K | SKCM | 3 |
| p.E365K | SKCM | 2 |
| p.S199R | LUAD | 2 |
| p.S233I | LUAD | 2 |
| p.I222M | LUAD | 2 |
| p.I342N | SKCM | 1 |
| p.R119* | SKCM | 1 |
| p.L314I | LUAD | 1 |
| p.L113F | LUAD | 1 |
| p.L306F | SKCM | 1 |
| p.D15G | STAD | 1 |
| p.G303V | LUAD | 1 |
| p.L107P | BRCA | 1 |
| p.L294R | ESCA | 1 |
| p.S360L | SKCM | 1 |
| p.Q257* | PAAD | 1 |
| p.A144V | LUSC | 1 |
| p.K324R | SKCM | 1 |
| p.H71N | PRAD | 1 |
| p.L70M | LUAD | 1 |
| p.F201L | SKCM | 1 |
| p.Y63C | HNSC | 1 |
| p.R234Q | GBM | 1 |
| p.V162I | STAD | 1 |
| p.E317K | SKCM | 1 |
| p.E66* | BLCA | 1 |
| p.L70V | STAD | 1 |
| p.N208Y | READ | 1 |
| p.E124K | SKCM | 1 |
| p.R373I | UCEC | 1 |
| p.S131G | COAD | 1 |
| p.A223S | LUAD | 1 |
| p.R242T | ESCA | 1 |
| p.P115H | LUSC | 1 |
| p.P73H | LUAD | 1 |
| p.C375* | STAD | 1 |
| p.R234W | READ | 1 |
| p.Y295* | LUAD | 1 |
| p.K329N | LUAD | 1 |
| p.A143T | STAD | 1 |
| p.G77V | KIRC | 1 |
| p.M315I | UCEC | 1 |
| p.R119L | LUAD | 1 |
| p.R119* | HNSC | 1 |
| p.Q257* | SKCM | 1 |
| p.G30E | SKCM | 1 |
| p.P265L | SKCM | 1 |
| p.L78M | LUAD | 1 |
| p.G17V | LGG | 1 |
| p.S112F | SKCM | 1 |
| p.M183I | LGG | 1 |
| p.M85I | BLCA | 1 |
| p.D84N | SKCM | 1 |
| p.S26C | CESC | 1 |
| p.G302W | OV | 1 |
| p.R313S | LGG | 1 |
| p.V38A | LUAD | 1 |
| p.Q59H | LUAD | 1 |
| p.D335N | SKCM | 1 |
| p.G161W | LUAD | 1 |
| p.G27R | SKCM | 1 |
| p.A141V | LUSC | 1 |
| p.V358I | UCEC | 1 |
| p.E260X | STAD | 1 |
| p.C286G | OV | 1 |
| p.P327A | LUAD | 1 |
| p.L107R | LUAD | 1 |
| p.H140Q | ACC | 1 |
| p.G81* | HNSC | 1 |
| p.E312K | SKCM | 1 |
| p.D245Y | UCEC | 1 |
| p.S323Y | LUAD | 1 |
| p.E170D | UCEC | 1 |
| p.E236D | UCEC | 1 |
| p.R242K | SKCM | 1 |
| p.R231C | OV | 1 |
| p.V151D | UCEC | 1 |
| p.G303C | LUAD | 1 |
| p.R50K | SKCM | 1 |
| p.P334S | HNSC | 1 |
| p.E75* | PRAD | 1 |
| p.E75K | LIHC | 1 |
| p.G19E | SKCM | 1 |
| p.K316N | OV | 1 |
| p.A141V | GBM | 1 |
| p.A223T | OV | 1 |
| p.E217V | THYM | 1 |
| p.E86D | UCEC | 1 |
| p.R32C | SKCM | 1 |
| p.E75A | PRAD | 1 |
| p.T368K | OV | 1 |
| p.H33Y | LUAD | 1 |
| p.S276* | BLCA | 1 |
| p.E260* | STAD | 1 |
| p.A184S | LUAD | 1 |
| p.E311V | LUAD | 1 |
| p.E128* | UCEC | 1 |
| p.R231C | COAD | 1 |
| p.R374K | COAD | 1 |
| p.V38I | BRCA | 1 |
| p.F130Y | LUAD | 1 |
| p.S333F | SKCM | 1 |
| p.S349F | SKCM | 1 |
| p.G27E | SKCM | 1 |
| p.L294R | STAD | 1 |
| p.R116M | KIRC | 1 |
| p.S272R | HNSC | 1 |
| p.H247Y | UCEC | 1 |
| p.S102R | SKCM | 1 |
| p.S37F | SKCM | 1 |
| p.H91P | GBM | 1 |
| p.Q257X | SKCM | 1 |
| p.R32C | KIRP | 1 |
| p.V38I | COAD | 1 |
| p.K329R | STAD | 1 |
| p.P167T | STAD | 1 |
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| TissGeneCNV for ACTRT1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ACTRT1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ACTRT1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ACTRT1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ACTRT1 |
| TissGeneDrug for ACTRT1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ACTRT1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0014511 | Epithelial cyst | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0266999 | Vesicular Stomatitis | 1 | BeFree |
| umls:C0558356 | Malignant melanoma of eye | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1511291 | Breast Cancer Model | 1 | BeFree |
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