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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ADORA3
check button Gene summary
Basic gene informationGene symbolADORA3
Gene nameadenosine A3 receptor
SynonymsA3AR
CytomapUCSC genome browser: 1p13.2
Type of geneprotein-coding
RefGenesNM_000677.3,
NM_001302678.1,NM_001302679.1,
Descriptionadenosine receptor A3
Modification date20141207
dbXrefs MIM : 600445
HGNC : HGNC
Ensembl : ENSG00000121933
HPRD : 08984
HPRD : 12424
Vega : OTTHUMG00000011957
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADORA3
BioGPS: 140
PathwayNCI Pathway Interaction Database: ADORA3
KEGG: ADORA3
REACTOME: ADORA3
Pathway Commons: ADORA3
ContextiHOP: ADORA3
ligand binding site mutation search in PubMed: ADORA3
UCL Cancer Institute: ADORA3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of ADORA3
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ADORA3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC1.930556717-1.4529085613.3834652782.15E-366.34E-35
LIHC-1.0686230610.602150939-1.6707745.10E-105.87E-09
KIRP0.800819564-1.9587804362.75963.77E-125.60E-11
COAD-0.9302402920.820994323-1.7512346152.10E-081.71E-07
KICH-0.598317061-1.7299050611.1315880.002570.005158725


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TissGene-miRNA for ADORA3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ADORA3
TissGeneSNV for ADORA3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R205WUCEC1
p.I253MCESC1
p.G177ESKCM1
p.N327KKIRP1
p.S231ASTAD1
p.T211MCOAD1
p.D166NSKCM1
p.Y15CPRAD1
p.L31FCESC1
p.W20XSKCM1
p.R285CSTAD1
p.E17KSKCM1
p.D247NSKCM1
p.A195TLUSC1
p.R205QSKCM1
p.R189QSTAD1
p.M18ISKCM1
p.P145LSKCM1
p.A105TLGG1
p.E259KSKCM1
p.E19KPAAD1
p.T169MHNSC1
p.S271FSKCM1
p.H95LLIHC1
p.D175NCOAD1
p.I27TBLCA1
p.R289HUCEC1
p.R159KSKCM1
p.D288GUCEC1
p.R205WSKCM1
p.R112CSKCM1
p.A178SLIHC1
p.R289HBRCA1
p.D213NSKCM1
p.W128*SKCM1
p.L90VDLBC1
p.P279HCOAD1
p.G258ESKCM1
p.S306PBLCA1
p.I59VSARC1
p.S271*CESC1
p.K119RBLCA1
p.A105TSTAD1
p.K282NKIRP1
p.M66TESCA1
p.I301NBLCA1
p.K274NUCEC1
p.D153ALUAD1
p.S165*LUAD1
p.E19KSKCM1
p.Y81CSARC1
p.E21KSKCM1
p.A96TCOAD1
p.E340KSKCM1
p.L297FSKCM1
p.A170TSTAD1
p.I20LLGG1
p.D158NUCEC1
p.A195TPAAD1
p.A105TLUAD1
p.A240TLIHC1
p.S35LBLCA1
p.W20*SKCM1
p.G29DUCEC1
p.A240TCOAD1
p.F80YOV1
p.V171IPAAD1
p.R205QLUAD1
p.L183FPRAD1
p.R289HESCA1
p.T221IHNSC1
p.R193CSKCM1
p.W187LHNSC1
p.C174YBRCA1
p.M174IOV1
p.A299SPRAD1
p.V171IUCEC1
p.V116ISTAD1


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TissGeneCNV for ADORA3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ADORA3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAF226731TRIP4-ADORA3chr15:64713987chr1:112025970
Chimerdb3.0ChiTaRsNAAV705429TRIP4-ADORA3chr15:64713987chr1:112031298
TCGAfusionPortalPRADABRCATCGA-A2-A0YE-01AGDAP2-ADORA3Out-of-frameChr1:118420631Chr1:112043178
TCGAfusionPortalPRADALUADTCGA-50-5066-01ATMED5-ADORA3Out-of-frameChr1:93645611Chr1:112028462


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TissGeneNet for ADORA3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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COAD (tumor)COAD (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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HNSC (tumor)HNSC (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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KICH (tumor)KICH (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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KIRC (tumor)KIRC (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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KIRP (tumor)KIRP (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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LIHC (tumor)LIHC (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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LUAD (tumor)LUAD (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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LUSC (tumor)LUSC (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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PRAD (tumor)PRAD (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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STAD (tumor)STAD (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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THCA (tumor)THCA (normal)
ADORA3, YWHAZ, YWHAQ (tumor)ADORA3, YWHAZ, YWHAQ (normal)
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TissGeneProg for ADORA3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ADORA3
TissGeneDrug for ADORA3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ADORA3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027051Myocardial Infarction3CTD_human,GAD
umls:C0013182Drug Allergy2GAD
umls:C0021390Inflammatory Bowel Diseases2BeFree
umls:C0022116Ischemia2BeFree,CTD_human
umls:C1458155Mammary Neoplasms2LHGDN
umls:C0004096Asthma1GAD
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009375Colonic Neoplasms1LHGDN
umls:C0009404Colorectal Neoplasms1LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0017661IGA Glomerulonephritis1CTD_human
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0042109Urticaria1BeFree,GAD
umls:C0151744Myocardial Ischemia1GAD
umls:C0178874Tumor Progression1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0878544Cardiomyopathies1GAD
umls:C2239176Liver carcinoma1LHGDN