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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CRP
check button Gene summary
Basic gene informationGene symbolCRP
Gene nameC-reactive protein, pentraxin-related
SynonymsPTX1
CytomapUCSC genome browser: 1q23.2
Type of geneprotein-coding
RefGenesNM_000567.2,
DescriptionC-reactive proteinpentraxin 1
Modification date20141222
dbXrefs MIM : 123260
HGNC : HGNC
Ensembl : ENSG00000132693
HPRD : 00422
Vega : OTTHUMG00000035344
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CRP
BioGPS: 1401
PathwayNCI Pathway Interaction Database: CRP
KEGG: CRP
REACTOME: CRP
Pathway Commons: CRP
ContextiHOP: CRP
ligand binding site mutation search in PubMed: CRP
UCL Cancer Institute: CRP
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of CRP
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0010628positive regulation of gene expression24141169
GO:0010745negative regulation of macrophage derived foam cell differentiation18322245
GO:0010888negative regulation of lipid storage18322245
GO:0032930positive regulation of superoxide anion generation24141169
GO:0045908negative regulation of vasodilation24141169
GO:2000482regulation of interleukin-8 secretion21037097
GO:0010628positive regulation of gene expression24141169
GO:0010745negative regulation of macrophage derived foam cell differentiation18322245
GO:0010888negative regulation of lipid storage18322245
GO:0032930positive regulation of superoxide anion generation24141169
GO:0045908negative regulation of vasodilation24141169
GO:2000482regulation of interleukin-8 secretion21037097


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TissGeneExp for CRP

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC0.999956695-0.5952308051.59518751.90E-064.75E-06
LIHC11.0617613113.86219531-2.8004340.0001410.000469507


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TissGene-miRNA for CRP

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CRP
TissGeneSNV for CRP

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S71LSKCM3
p.S159FSKCM3
p.E156VLUSC1
p.A207TSTAD1
p.E148KSKCM1
p.D158YSTAD1
p.R76KSKCM1
p.V95MUCEC1
p.G214SSKCM1
p.K75NUCEC1
p.S159FSARC1
p.Y91FLUAD1
p.K87NUCEC1
p.A121TTHCA1
p.P43LHNSC1
p.K137MSKCM1
p.G131RLUAD1
p.Q155XLIHC1
p.A73TSTAD1
p.Y91CESCA1
p.E156*LUSC1
p.G214CLUSC1
p.V112IUCEC1
p.D34NSKCM1
p.E188GSTAD1
p.W180*SKCM1
p.G175RSKCM1
p.G142ESKCM1
p.G195DSTAD1
p.E188KSKCM1
p.L194FSKCM1
p.H15YBLCA1
p.P30SLUSC1
p.E80KSKCM1
p.S150ILUAD1
p.G175ESKCM1
p.S63LSKCM1
p.A50SBRCA1
p.K75NTHYM1
p.N163YSTAD1
p.F29LHNSC1
p.S39FLUAD1
p.S169PUCEC1
p.D88GBRCA1
p.E103DGBM1
p.P105SLUSC1
p.P30LLUSC1
p.R206PLUAD1
p.S122LBLCA1
p.E32*UCEC1
p.P105HREAD1
p.G166ESKCM1
p.K25NLUAD1


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TissGeneCNV for CRP

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CRP

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAA344463CRP-SEPHS2chr1:159683212chr16:30456286


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TissGeneNet for CRP

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CRP, RPL13A, NFKB2, NFKB1, CEBPB, MAPK1, FN1, STAT3, FCGR1A, SNRNP70, FCGR2B, DGCR14, HNF1A, CEBPD, POU2F1, FCGR2C, FCN2, C1QA, CEBPZ, FCGR2A, RBPJ (tumor)CRP, RPL13A, NFKB2, CEBPB, MAPK1, GLUD1, SNRNP70, APCS, FCGR2B, DGCR14, LAMC3, CEBPD, POU2F1, CFH, FCN2, C1QA, IL6, CEBPZ, FCAR, CFHR4, LEP (normal)
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COAD (tumor)COAD (normal)
CRP, RPL13A, NFKB1, CEBPB, MAPK1, STAT3, CTNNB1, FCGR1A, APCS, FCGR2B, CEBPA, MAPK3, CEBPD, POU2F1, GP6, FCGR2C, FCN2, C1QA, IL6, CEBPZ, CFHR4 (tumor)CRP, NFKB2, CEBPB, FN1, STAT3, CTNNB1, FCGR1A, SNRNP70, HIST1H2AG, APCS, FCGR2B, DGCR14, CEBPA, MAPK3, HNF1A, CEBPD, CFH, HIST1H1A, CEBPZ, RBPJ, LEP (normal)
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HNSC (tumor)HNSC (normal)
CRP, RPL13A, NFKB1, CEBPB, MAPK1, CTNNB1, FCGR1A, GLUD1, SNRNP70, APCS, FCGR2B, DGCR14, CEBPA, HNF1A, CEBPD, POU2F1, C1QA, CEBPZ, FCGR2A, CFHR4, LEP (tumor)CRP, MAPK1, FN1, FCGR1A, GLUD1, SNRNP70, HIST1H2AG, APCS, FCGR2B, DGCR14, LAMC3, CEBPA, MAPK3, CEBPD, POU2F1, GP6, FCGR2C, IL6, FCGR2A, FCAR, CFHR4 (normal)
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KICH (tumor)KICH (normal)
CRP, RPL13A, NFKB1, CEBPB, MAPK1, CTNNB1, FCGR1A, FCGR2B, CEBPA, MAPK3, CEBPD, CFH, GP6, FCGR2C, HIST1H1A, FCN2, C1QA, IL6, FCGR2A, FCAR, CFHR4 (tumor)CRP, NFKB2, NFKB1, CEBPB, MAPK1, FN1, FCGR1A, GLUD1, SNRNP70, FCGR2B, DGCR14, CEBPD, POU2F1, GP6, FCGR2C, HIST1H1A, C1QA, IL6, FCGR2A, FCAR, RBPJ (normal)
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KIRC (tumor)KIRC (normal)
CRP, NFKB2, CEBPB, MAPK1, FCGR1A, GLUD1, APCS, FCGR2B, LAMC3, CEBPA, MAPK3, HNF1A, CFH, FCGR2C, HIST1H1A, FCN2, C1QA, CEBPZ, FCGR2A, CFHR4, LEP (tumor)CRP, RPL13A, CEBPB, FN1, STAT3, CTNNB1, FCGR1A, APCS, FCGR2B, CEBPA, POU2F1, CFH, FCGR2C, FCN2, C1QA, IL6, CEBPZ, FCGR2A, CFHR4, RBPJ, LEP (normal)
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KIRP (tumor)KIRP (normal)
CRP, NFKB1, CEBPB, MAPK1, STAT3, FCGR1A, SNRNP70, HIST1H2AG, FCGR2B, DGCR14, MAPK3, HNF1A, CFH, GP6, FCGR2C, HIST1H1A, FCN2, C1QA, FCGR2A, FCAR, CFHR4 (tumor)CRP, RPL13A, NFKB2, NFKB1, CEBPB, FN1, STAT3, CTNNB1, FCGR1A, GLUD1, APCS, LAMC3, CEBPA, MAPK3, HNF1A, CEBPD, CFH, C1QA, IL6, FCGR2A, CFHR4 (normal)
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LIHC (tumor)LIHC (normal)
CRP, NFKB2, NFKB1, CEBPB, FN1, STAT3, FCGR1A, GLUD1, SNRNP70, HIST1H2AG, APCS, FCGR2B, CEBPA, HNF1A, CEBPD, CFH, FCGR2C, CEBPZ, FCAR, CFHR4, RBPJ (tumor)CRP, NFKB2, CEBPB, MAPK1, STAT3, CTNNB1, FCGR1A, GLUD1, HIST1H2AG, APCS, FCGR2B, LAMC3, CEBPD, CFH, FCGR2C, C1QA, IL6, CEBPZ, FCGR2A, CFHR4, RBPJ (normal)
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LUAD (tumor)LUAD (normal)
CRP, NFKB2, NFKB1, FN1, CTNNB1, GLUD1, SNRNP70, HIST1H2AG, DGCR14, LAMC3, CEBPA, HNF1A, CEBPD, POU2F1, CFH, GP6, FCN2, C1QA, IL6, CEBPZ, CFHR4 (tumor)CRP, NFKB2, CEBPB, MAPK1, CTNNB1, SNRNP70, HIST1H2AG, APCS, LAMC3, CEBPA, MAPK3, HNF1A, POU2F1, CFH, GP6, HIST1H1A, FCN2, IL6, FCGR2A, CFHR4, RBPJ (normal)
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LUSC (tumor)LUSC (normal)
CRP, NFKB2, CEBPB, MAPK1, FN1, STAT3, CTNNB1, FCGR1A, SNRNP70, HIST1H2AG, APCS, DGCR14, MAPK3, HNF1A, CEBPD, POU2F1, CFH, GP6, HIST1H1A, FCAR, RBPJ (tumor)CRP, RPL13A, NFKB2, CEBPB, MAPK1, STAT3, FCGR1A, HIST1H2AG, APCS, CEBPA, MAPK3, HNF1A, CEBPD, POU2F1, CFH, GP6, HIST1H1A, FCN2, C1QA, FCGR2A, CFHR4 (normal)
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PRAD (tumor)PRAD (normal)
CRP, RPL13A, NFKB2, NFKB1, CEBPB, FCGR1A, SNRNP70, APCS, DGCR14, LAMC3, CEBPA, MAPK3, HNF1A, CEBPD, POU2F1, FCGR2C, HIST1H1A, FCN2, CEBPZ, FCAR, LEP (tumor)CRP, NFKB2, NFKB1, CEBPB, MAPK1, STAT3, FCGR1A, GLUD1, SNRNP70, APCS, FCGR2B, DGCR14, MAPK3, CEBPD, CFH, FCGR2C, C1QA, IL6, FCGR2A, FCAR, CFHR4 (normal)
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STAD (tumor)STAD (normal)
CRP, RPL13A, NFKB2, CEBPB, MAPK1, FN1, CTNNB1, FCGR1A, GLUD1, HIST1H2AG, APCS, DGCR14, CEBPA, CEBPD, POU2F1, HIST1H1A, IL6, CEBPZ, FCAR, RBPJ, LEP (tumor)CRP, RPL13A, CEBPB, FN1, STAT3, CTNNB1, APCS, FCGR2B, DGCR14, CEBPA, HNF1A, CEBPD, POU2F1, FCGR2C, HIST1H1A, FCN2, IL6, CEBPZ, FCAR, CFHR4, LEP (normal)
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THCA (tumor)THCA (normal)
CRP, RPL13A, NFKB2, NFKB1, CEBPB, MAPK1, GLUD1, SNRNP70, HIST1H2AG, FCGR2B, MAPK3, CEBPD, FCGR2C, HIST1H1A, C1QA, IL6, CEBPZ, FCGR2A, FCAR, RBPJ, LEP (tumor)CRP, RPL13A, NFKB2, CEBPB, FN1, FCGR1A, SNRNP70, APCS, FCGR2B, LAMC3, HNF1A, CEBPD, CFH, GP6, FCGR2C, C1QA, IL6, CEBPZ, FCGR2A, FCAR, RBPJ (normal)
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TissGeneProg for CRP

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CRP
TissGeneDrug for CRP

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CRP

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007222Cardiovascular Diseases140BeFree,CTD_human,GAD,LHGDN
umls:C0004153Atherosclerosis94BeFree,CTD_human,GAD,LHGDN
umls:C0010068Coronary heart disease90BeFree,GAD,LHGDN
umls:C0003850Arteriosclerosis80BeFree,LHGDN
umls:C0003873Rheumatoid Arthritis66BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0010054Coronary Arteriosclerosis64BeFree,GAD
umls:C1956346Coronary Artery Disease62BeFree,CTD_human,GAD,LHGDN
umls:C0028754Obesity58BeFree,CTD_human,GAD
umls:C0011849Diabetes Mellitus53BeFree,GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent48BeFree,GAD,LHGDN
umls:C0011847Diabetes47BeFree
umls:C0027051Myocardial Infarction44BeFree,GAD,LHGDN,RGD
umls:C0020538Hypertensive disease37BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0524620Metabolic Syndrome X37BeFree,CTD_human,GAD,LHGDN
umls:C0038454Cerebrovascular accident36BeFree,GAD,LHGDN
umls:C0021368Inflammation31CTD_human,GAD,LHGDN,RGD
umls:C0024141Lupus Erythematosus, Systemic23BeFree,CTD_human,GAD,LHGDN
umls:C0242383Age related macular degeneration20BeFree,GAD,LHGDN
umls:C0948008Ischemic stroke19BeFree,GAD
umls:C0948089Acute Coronary Syndrome17BeFree,CTD_human,GAD,LHGDN
umls:C3272363Ischemic Cerebrovascular Accident17BeFree
umls:C0151744Myocardial Ischemia14BeFree,CTD_human,GAD,RGD
umls:C0243026Sepsis14BeFree,RGD
umls:C2239176Liver carcinoma14BeFree,CTD_human,LHGDN
umls:C0010346Crohn Disease13BeFree,CTD_human,GAD,LHGDN
umls:C0042373Vascular Diseases13BeFree,GAD,LHGDN
umls:C0155626Acute myocardial infarction13BeFree
umls:C0009402Colorectal Carcinoma12BeFree
umls:C0011570Mental Depression12BeFree,GAD
umls:C0011581Depressive disorder12BeFree
umls:C0036690Septicemia12BeFree
umls:C1527249Colorectal Cancer12BeFree,GAD
umls:C0024117Chronic Obstructive Airway Disease11BeFree,GAD,LHGDN
umls:C0497406Overweight11BeFree
umls:C0856169Endothelial dysfunction11BeFree
umls:C0018799Heart Diseases10BeFree,CTD_human,GAD
umls:C0023903Liver neoplasms10BeFree
umls:C0038013Ankylosing spondylitis10BeFree,LHGDN
umls:C0242379Malignant neoplasm of lung10BeFree,GAD
umls:C0338656Impaired cognition10BeFree
umls:C0031069Familial Mediterranean Fever9BeFree,LHGDN
umls:C0032285Pneumonia9BeFree
umls:C0376358Malignant neoplasm of prostate9BeFree,GAD
umls:C0497327Dementia9BeFree,LHGDN
umls:C0002395Alzheimer's Disease8BeFree,GAD,LHGDN
umls:C0004364Autoimmune Diseases8BeFree,LHGDN
umls:C0006142Malignant neoplasm of breast8BeFree
umls:C0011265Presenile dementia8BeFree
umls:C0018801Heart failure8BeFree,CTD_human
umls:C0018802Congestive heart failure8BeFree
umls:C0600139Prostate carcinoma8BeFree
umls:C0004623Bacterial Infections7BeFree,LHGDN
umls:C0009324Ulcerative Colitis7BeFree,LHGDN
umls:C0011854Diabetes Mellitus, Insulin-Dependent7BeFree,CTD_human
umls:C0022661Kidney Failure, Chronic7BeFree,CTD_human,GAD,LHGDN
umls:C0025517Metabolic Diseases7BeFree,CTD_human,LHGDN
umls:C0031099Periodontitis7BeFree,CTD_human
umls:C0032460Polycystic Ovary Syndrome7BeFree,LHGDN
umls:C0033860Psoriasis7BeFree,CTD_human
umls:C0040038Thromboembolism7BeFree
umls:C0152031Joint swelling7BeFree
umls:C0333307Superficial ulcer7BeFree
umls:C0678222Breast Carcinoma7BeFree
umls:C0684249Carcinoma of lung7BeFree
umls:C3714514Infection7CTD_human,GAD,LHGDN
umls:C0002965Angina, Unstable6BeFree,GAD,LHGDN
umls:C0004096Asthma6BeFree,LHGDN
umls:C0004610Bacteremia6BeFree,GAD
umls:C0021390Inflammatory Bowel Diseases6BeFree
umls:C0022116Ischemia6BeFree,GAD,LHGDN
umls:C0022658Kidney Diseases6BeFree,GAD,LHGDN
umls:C0024530Malaria6BeFree,CTD_human
umls:C0032269Pneumococcal Infections6BeFree
umls:C0232197Fibrillation6BeFree
umls:C0242339Dyslipidemias6BeFree,LHGDN
umls:C0340288Stable angina6BeFree
umls:C0520679Sleep Apnea, Obstructive6BeFree,GAD,LHGDN
umls:C0947751Vascular inflammations6BeFree
umls:C1290884Inflammatory disorder6BeFree
umls:C1561643Chronic Kidney Diseases6BeFree
umls:C0002871Anemia5BeFree
umls:C0007137Squamous cell carcinoma5BeFree,GAD,LHGDN
umls:C0007273Carotid Artery Diseases5GAD,LHGDN
umls:C0014859Esophageal Neoplasms5BeFree,GAD
umls:C0019693HIV Infections5BeFree
umls:C0020445Hypercholesterolemia, Familial5BeFree
umls:C0023530Leukopenia5BeFree
umls:C0024131Lupus Vulgaris5BeFree
umls:C0024138Lupus Erythematosus, Discoid5BeFree
umls:C0032002Pituitary Diseases5BeFree
umls:C0036341Schizophrenia5BeFree
umls:C0085207Gestational Diabetes5BeFree,LHGDN
umls:C0221014Reactive systemic amyloidosis5BeFree
umls:C0409974Lupus Erythematosus5BeFree
umls:C0546837Malignant neoplasm of esophagus5BeFree,GAD
umls:C0686619Secondary malignant neoplasm of lymph node5BeFree
umls:C0729233Dissecting aneurysm of the thoracic aorta5BeFree
umls:C0001430Adenoma4BeFree,GAD
umls:C0004238Atrial Fibrillation4GAD,LHGDN
umls:C0006625Cachexia4BeFree
umls:C0007131Non-Small Cell Lung Carcinoma4BeFree
umls:C0007282Carotid Stenosis4BeFree,GAD,LHGDN
umls:C0009404Colorectal Neoplasms4GAD,LHGDN,RGD
umls:C0021655Insulin Resistance4GAD
umls:C0022408Arthropathy4BeFree
umls:C0024437Macular degeneration4BeFree
umls:C0036421Systemic Scleroderma4BeFree,LHGDN
umls:C0086132Depressive Symptoms4BeFree
umls:C0149871Deep Vein Thrombosis4BeFree
umls:C0162871Aortic Aneurysm, Abdominal4BeFree,LHGDN
umls:C0400966Non-alcoholic Fatty Liver Disease4BeFree
umls:C0403447Chronic Kidney Insufficiency4BeFree
umls:C1704436Peripheral Arterial Diseases4BeFree
umls:C0003507Aortic Valve Stenosis3BeFree
umls:C0003864Arthritis3BeFree
umls:C0007102Malignant tumor of colon3BeFree
umls:C0007193Cardiomyopathy, Dilated3BeFree
umls:C0007786Brain Ischemia3GAD
umls:C0007820Cerebrovascular Disorders3GAD
umls:C0011884Diabetic Retinopathy3BeFree,CTD_human
umls:C0020179Huntington Disease3BeFree
umls:C0020443Hypercholesterolemia3BeFree,LHGDN
umls:C0020459Hyperinsulinism3BeFree,LHGDN
umls:C0021400Influenza3BeFree
umls:C0023890Liver Cirrhosis3BeFree,GAD,LHGDN
umls:C0024143Lupus Nephritis3BeFree,LHGDN
umls:C0024535Malaria, Falciparum3BeFree,GAD
umls:C0026691Mucocutaneous Lymph Node Syndrome3BeFree,LHGDN
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0085580Essential Hypertension3BeFree
umls:C0085663Plasmacytosis3BeFree
umls:C0152018Esophageal carcinoma3BeFree
umls:C0155668Old myocardial infarction3BeFree
umls:C0221599Morning stiffness (>1 hour)3BeFree
umls:C0221757alpha 1-Antitrypsin Deficiency3BeFree
umls:C0311277Obesity, Abdominal3BeFree
umls:C0333186Restenosis3BeFree
umls:C0342276Maturity onset diabetes mellitus in young3BeFree
umls:C0699790Colon Carcinoma3BeFree
umls:C0751955Brain Infarction3BeFree,GAD,LHGDN
umls:C1301700Cardiovascular morbidity3BeFree
umls:C3536715AA amyloidosis3BeFree
umls:C0003486Aortic Aneurysm2BeFree
umls:C0003862Arthralgia2BeFree
umls:C0003872Arthritis, Psoriatic2BeFree
umls:C0007113Rectal Carcinoma2BeFree
umls:C0007771Intracranial Arteriosclerosis2GAD
umls:C0007787Transient Ischemic Attack2BeFree,GAD,LHGDN
umls:C0009782Connective Tissue Diseases2BeFree,GAD
umls:C0014061Tick-Borne Encephalitis2BeFree
umls:C0014170Endometrial Neoplasms2GAD,LHGDN
umls:C0017658Glomerulonephritis2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0019829Hodgkin Disease2BeFree
umls:C0020456Hyperglycemia2BeFree,GAD
umls:C0020473Hyperlipidemia2BeFree,RGD
umls:C0022660Kidney Failure, Acute2BeFree
umls:C0023343Leprosy2BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia2BeFree
umls:C0024121Lung Neoplasms2CTD_human,LHGDN
umls:C0025289Meningitis2BeFree,CTD_human
umls:C0026764Multiple Myeloma2BeFree
umls:C0027059Myocarditis2BeFree,CTD_human
umls:C0028756Obesity, Morbid2BeFree
umls:C0029408Degenerative polyarthritis2BeFree,GAD
umls:C0029443Osteomyelitis2BeFree
umls:C0029928Ovarian Diseases2BeFree
umls:C0030312Pancytopenia2BeFree
umls:C0031090Periodontal Diseases2BeFree,LHGDN
umls:C0032310Pneumonia, Viral2BeFree
umls:C0033578Prostatic Neoplasms2BeFree,LHGDN
umls:C0034065Pulmonary Embolism2BeFree,GAD,LHGDN
umls:C0035078Kidney Failure2BeFree
umls:C0035435Rheumatism2LHGDN
umls:C0038160Staphylococcal Infections2GAD
umls:C0040053Thrombosis2CTD_human,LHGDN
umls:C0041696Unipolar Depression2BeFree
umls:C0042384Vasculitis2BeFree,GAD
umls:C0042769Virus Diseases2BeFree
umls:C0043144Wheezing2BeFree
umls:C0085400Neurofibrillary degeneration (morphologic abnormality)2BeFree
umls:C0151526Premature Birth2GAD
umls:C0151942Arterial thrombosis2BeFree,GAD
umls:C0151950Deep thrombophlebitis2BeFree
umls:C0162429Malnutrition2BeFree
umls:C0240066Iron deficiency2BeFree
umls:C0242172Pelvic Inflammatory Disease2BeFree
umls:C0242231Coronary Stenosis2LHGDN
umls:C0271084Exudative age-related macular degeneration2BeFree
umls:C0271650Impaired glucose tolerance2BeFree
umls:C0279628Adenocarcinoma Of Esophagus2BeFree
umls:C0282193Iron Overload2BeFree
umls:C0333463Senile Plaques2BeFree
umls:C0340293Anterior myocardial infarction2BeFree
umls:C0483368Human anaplasmosis due to Anaplasma phagocytophilum2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0600518Choroidal Neovascularization2GAD
umls:C0694549Community acquired pneumonia2BeFree
umls:C0747479Periodontal infection2BeFree
umls:C0751633Carotid Artery Plaque2BeFree
umls:C0751956Acute Cerebrovascular Accidents2BeFree
umls:C0836924Thrombocytosis2BeFree
umls:C0854706Neonatal infection2BeFree
umls:C0919267ovarian neoplasm2BeFree,LHGDN
umls:C0936223Metastatic Prostate Carcinoma2BeFree
umls:C1142127Pneumococcal bacteraemia2BeFree
umls:C1168401Squamous cell carcinoma of the head and neck2BeFree
umls:C1269683Major Depressive Disorder2BeFree
umls:C1275126TNF receptor-associated periodic fever syndrome (TRAPS)2BeFree
umls:C1290886Chronic inflammatory disorder2BeFree
umls:C1302401Adenoma of large intestine2BeFree
umls:C1397307Cardiac fibrosis2BeFree
umls:C1861172Venous Thromboembolism2GAD
umls:C2733158Cerebral Small Vessel Diseases2BeFree
umls:C2937358Cerebral Hemorrhage2GAD
umls:C3280586Mannose-Binding Protein Deficiency2BeFree
umls:C3542024AORTIC VALVE DISEASE 22BeFree
umls:C0000833Abscess1BeFree
umls:C0001206Acromegaly1BeFree
umls:C0001339Acute pancreatitis1BeFree
umls:C0001349Acute-Phase Reaction1GAD
umls:C0001925Albuminuria1GAD
umls:C0002940Aneurysm1BeFree
umls:C0002962Angina Pectoris1GAD
umls:C0002986Fabry Disease1BeFree,GAD,LHGDN
umls:C0003469Anxiety Disorders1CTD_human
umls:C0003838Arterial Occlusive Diseases1BeFree
umls:C0003868Arthritis, Gouty1BeFree
umls:C0003869Arthritis, Infectious1LHGDN
umls:C0003944As If Personality1GAD
umls:C0004626Pneumonia, Bacterial1BeFree
umls:C0005586Bipolar Disorder1LHGDN
umls:C0005684Malignant neoplasm of urinary bladder1GAD
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007133Carcinoma, Papillary1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree,LHGDN
umls:C0007775Cerebral Atherosclerosis1BeFree
umls:C0007785Cerebral Infarction1LHGDN
umls:C0008031Chest Pain1LHGDN
umls:C0008626Congenital chromosomal disease1BeFree
umls:C0009375Colonic Neoplasms1LHGDN
umls:C0010051Coronary Aneurysm1BeFree
umls:C0010201Chronic cough1BeFree
umls:C0010823Cytomegalovirus Infections1BeFree
umls:C0011065Cessation of life1LHGDN
umls:C0011119Decompression Sickness1BeFree
umls:C0011269Dementia, Vascular1LHGDN
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0013537Eclampsia1BeFree
umls:C0014038Encephalitis1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0015696Fatty Liver, Alcoholic1RGD
umls:C0015929Fetal Diseases1GAD
umls:C0016867Furunculosis1GAD
umls:C0018203Chronic granulomatous disease1BeFree
umls:C0018800Cardiomegaly1LHGDN
umls:C0018813Myocardial rupture1BeFree
umls:C0019080Hemorrhage1LHGDN
umls:C0019158Hepatitis1BeFree
umls:C0019159Hepatitis A1BeFree
umls:C0019202Hepatolenticular Degeneration1BeFree
umls:C0019243Angioedemas, Hereditary1BeFree
umls:C0019340Herpes NOS1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0020455Hypergammaglobulinemia1BeFree
umls:C0020503Hyperparathyroidism, Secondary1CTD_human
umls:C0020544Renal hypertension1RGD
umls:C0020557Hypertriglyceridemia1CTD_human
umls:C0020951Immune Complex Diseases1BeFree
umls:C0021775Intermittent Claudication1BeFree
umls:C0021846Intestinal Polyps1GAD
umls:C0022672Acute Kidney Tubular Necrosis1BeFree
umls:C0023241Legionnaires' Disease1BeFree
umls:C0023281Leishmaniasis1CTD_human
umls:C0023290Leishmaniasis, Visceral1CTD_human
umls:C0023440Acute Erythroblastic Leukemia1BeFree
umls:C0023484Leukemia, Plasma Cell1BeFree
umls:C0023518Leukocytosis1GAD
umls:C0023893Liver Cirrhosis, Experimental1RGD
umls:C0023895Liver diseases1BeFree
umls:C0024115Lung diseases1LHGDN
umls:C0024232Lymphatic Metastasis1GAD
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0025202melanoma1BeFree
umls:C0025268Multiple Endocrine Neoplasia Type 2a1BeFree
umls:C0026636Mouth Diseases1RGD
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0026946Mycoses1BeFree
umls:C0027022Myeloproliferative disease1BeFree
umls:C0027055Myocardial Reperfusion Injury1RGD
umls:C0027404Narcolepsy1BeFree
umls:C0027707Nephritis, Interstitial1CTD_human
umls:C0027947Neutropenia1BeFree
umls:C0028432Nose Diseases1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0030305Pancreatitis1LHGDN
umls:C0031022Chronic periaortitis1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0032300Lobar Pneumonia1BeFree
umls:C0032302Mycoplasma pneumonia1BeFree
umls:C0032463Polycythemia Vera1BeFree
umls:C0032533Polymyalgia Rheumatica1GAD
umls:C0032897Prader-Willi Syndrome1BeFree
umls:C0032914Pre-Eclampsia1LHGDN
umls:C0032962Pregnancy Complications1LHGDN
umls:C0032964Pregnancy Complications, Hematologic1GAD
umls:C0033300Progeria1BeFree
umls:C0033817Pseudomonas Infections1RGD
umls:C0033975Psychotic Disorders1BeFree
umls:C0034186Pyelonephritis1RGD
umls:C0034359Pyuria1BeFree
umls:C0034642Rales1BeFree
umls:C0034885Rectal Neoplasms1BeFree
umls:C0035204Respiration Disorders1BeFree
umls:C0035242Respiratory Tract Diseases1BeFree
umls:C0035312Retinal Drusen1BeFree
umls:C0036983Septic Shock1LHGDN
umls:C0037274Dermatologic disorders1GAD
umls:C0038220Status Epilepticus1RGD
umls:C0038436Post-Traumatic Stress Disorder1BeFree
umls:C0038587Substance Withdrawal Syndrome1CTD_human
umls:C0039483Giant Cell Arteritis1BeFree,GAD
umls:C0039981Thoracic Neoplasms1GAD
umls:C0040028Thrombocythemia, Essential1BeFree
umls:C0040592Trachoma1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0041408Turner Syndrome1BeFree
umls:C0041912Upper Respiratory Infections1BeFree
umls:C0042109Urticaria1BeFree
umls:C0042995Vulvar Neoplasms1LHGDN
umls:C0085096Peripheral Vascular Diseases1GAD
umls:C0085119Foot Ulcer1LHGDN
umls:C0085278Antiphospholipid Syndrome1LHGDN
umls:C0085397Pasteurellaceae Infections1CTD_human
umls:C0149725Lower respiratory tract infection1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0155733Atherosclerosis of aorta1BeFree
umls:C0155765Disease of capillaries1BeFree
umls:C0155773Portal vein thrombosis1BeFree
umls:C0155862Streptococcal pneumonia1BeFree
umls:C0162316Iron deficiency anemia1RGD
umls:C0162538Immunoglobulin A deficiency (disorder)1BeFree
umls:C0206061Pneumonia, Interstitial1BeFree
umls:C0206064Microvascular Angina1LHGDN
umls:C0206081Hyperandrogenism1BeFree
umls:C0206172Diabetic Foot1LHGDN
umls:C0206669Hepatocellular Adenoma1BeFree
umls:C0206681Adenocarcinoma, Clear Cell1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0220989Acquired partial lipodystrophy1BeFree
umls:C0221019Sickle cell-beta-thalassemia1BeFree
umls:C0221214Vascular ring1BeFree
umls:C0233401Psychiatric symptom1BeFree
umls:C0238339Hereditary pancreatitis1BeFree
umls:C0238790bone destruction1BeFree
umls:C0242301furuncle1BeFree
umls:C0242387Mandibulofacial Dysostosis1BeFree
umls:C0242510Drug usage1BeFree
umls:C0242698Ventricular Dysfunction, Left1LHGDN
umls:C0263746Osteoarthritis of the hand1BeFree
umls:C0267380Crohn's disease of the ileum1BeFree
umls:C0267750Acute peritonitis1BeFree
umls:C0268380Systemic amyloidosis1BeFree
umls:C0268381Primary amyloidosis1BeFree
umls:C0268394Hereditary Cerebral Amyloid Angiopathy, Dutch Type1BeFree
umls:C0276653Invasive Pulmonary Aspergillosis1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0281479Primary Systemic Amyloidosis1BeFree
umls:C0311375Arsenic Poisoning1CTD_human
umls:C0334660Angioendotheliomatosis1BeFree
umls:C0340643Dissection of aorta1BeFree
umls:C0340971Autoimmune neutropenia1BeFree
umls:C0342257Complications of Diabetes Mellitus1GAD
umls:C0342883Cholesteryl Ester Transfer Protein Deficiency1BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0376620Pouchitis1BeFree
umls:C0393576Chorea Acanthocytosis Syndrome1BeFree
umls:C0398623Thrombophilia1BeFree
umls:C0398650Immune thrombocytopenic purpura1BeFree
umls:C0403592Chronic rejection of renal transplant1BeFree
umls:C0409957Osteoarthritis of distal interphalangeal joint1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0520459Necrotizing Enterocolitis1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0524909Hepatitis B, Chronic1BeFree
umls:C0549493Alveolitis1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0598608Hyperhomocysteinemia1BeFree
umls:C0600452Hepatopulmonary Syndrome1GAD
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0678201Terminal Ileitis1BeFree
umls:C0685938Malignant neoplasm of gastrointestinal tract1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0701807Acute anterior uveitis1BeFree
umls:C0741923cardiac event1BeFree
umls:C0746556metabolic disturbance1BeFree
umls:C0746883Febrile Neutropenia1BeFree
umls:C0751688Malignant Squamous Cell Neoplasm1BeFree
umls:C0796033MARDEN-WALKER SYNDROME1BeFree
umls:C0852949Arteriopathic disease1BeFree
umls:C0853879Invasive breast carcinoma1BeFree
umls:C0853897Diabetic Cardiomyopathies1BeFree
umls:C0856151Fat redistribution1BeFree
umls:C0856742Post MI1BeFree
umls:C0857812Sickle cell-beta^+^-thalassemia1BeFree
umls:C0917805Transient Cerebral Ischemia1BeFree
umls:C0920646Renal ischaemia1BeFree
umls:C0949059Polyp of large intestine1BeFree
umls:C0993582Arthritis, Experimental1CTD_human
umls:C1096458Vascular occlusion1BeFree
umls:C1142423Bacteremia due to Staphylococcus aureus1BeFree
umls:C1261287Stenosis1LHGDN
umls:C1270972Mild cognitive disorder1BeFree
umls:C1274282Acral pseudolymphomatous angiokeratoma of children (APACHE)1BeFree
umls:C1277187Left ventricular systolic dysfunction1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1449563Cardiomyopathy, Familial Idiopathic1BeFree
umls:C1527311Brain Edema1LHGDN
umls:C1527408Rectal Tumors1BeFree
umls:C1531624Cardioembolic stroke1BeFree
umls:C1536085Geographic Atrophy1BeFree
umls:C1562670Late onset schizophrenia1BeFree
umls:C1565489Renal Insufficiency1LHGDN
umls:C1619738Immune Reconstitution Inflammatory Syndrome1BeFree
umls:C1720775Renal tubular necrosis1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2717961Thrombotic Microangiopathies1GAD
umls:C2931788Atypical Hemolytic Uremic Syndrome1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C2939462Immunoglobulin deposition disease1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3495426Homocysteinemia1BeFree
umls:C3714619Insulin resistance syndrome1BeFree
umls:C3825973Metabolic disorders in children1BeFree
umls:C2609414Acute kidney injury0RGD