TissGeneSummary for ASB9 |
Gene summary |
Basic gene information | Gene symbol | ASB9 |
Gene name | ankyrin repeat and SOCS box containing 9 | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xp22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001031739.2, NM_001168530.1,NM_001168531.1,NM_024087.2, | |
Description | ASB-9ankyrin repeat and SOCS box protein 9ankyrin repeat and SOCS box-containing 9ankyrin repeat and suppressor of cytokine signaling box protein 9 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300890 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102048 | ||
HPRD : 06452 | ||
Vega : OTTHUMG00000021172 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ASB9 | |
BioGPS: 140462 | ||
Pathway | NCI Pathway Interaction Database: ASB9 | |
KEGG: ASB9 | ||
REACTOME: ASB9 | ||
Pathway Commons: ASB9 | ||
Context | iHOP: ASB9 | |
ligand binding site mutation search in PubMed: ASB9 | ||
UCL Cancer Institute: ASB9 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTGCT | |
Reference showing the relevant tissue of ASB9 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016567 | protein ubiquitination | 17148442 | GO:0045732 | positive regulation of protein catabolic process | 17148442 | GO:0016567 | protein ubiquitination | 17148442 | GO:0045732 | positive regulation of protein catabolic process | 17148442 |
Top |
TissGeneExp for ASB9 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.346594595 | 2.541198761 | -1.194604167 | 1.41E-16 | 8.02E-16 |
COAD | 1.832736689 | 0.099263612 | 1.733473077 | 1.08E-06 | 6.07E-06 |
KIRP | 1.1193939 | 2.782159525 | -1.662765625 | 2.76E-10 | 2.91E-09 |
LUSC | 0.388980052 | 1.474231033 | -1.08525098 | 8.79E-06 | 2.01E-05 |
KICH | 1.36228515 | 2.76135715 | -1.399072 | 0.00209 | 0.004273061 |
Top |
TissGene-miRNA for ASB9 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for ASB9 |
TissGeneSNV for ASB9 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G3D | UCEC | 1 |
p.V193A | STAD | 1 |
p.G6R | LUSC | 1 |
p.R234C | PAAD | 1 |
p.I65T | STAD | 1 |
p.F290L | UCEC | 1 |
p.L55F | TGCT | 1 |
p.E213* | GBM | 1 |
p.I56F | LUAD | 1 |
p.Q179R | LUAD | 1 |
p.L291F | BLCA | 1 |
p.S83F | LGG | 1 |
p.A14T | LGG | 1 |
p.S57I | PAAD | 1 |
p.P20H | LUAD | 1 |
p.W102* | PRAD | 1 |
p.H74R | BRCA | 1 |
p.L187V | LUSC | 1 |
p.G6V | LUSC | 1 |
p.S201Y | LUAD | 1 |
p.W102* | UCEC | 1 |
p.N54K | TGCT | 1 |
p.A227S | LUAD | 1 |
p.R143W | LUSC | 1 |
p.P170T | LUSC | 1 |
p.I22S | STAD | 1 |
p.A215S | HNSC | 1 |
p.A191V | PCPG | 1 |
p.S257P | BRCA | 1 |
p.K163T | STAD | 1 |
p.G198D | BRCA | 1 |
p.E188* | HNSC | 1 |
p.S243N | PAAD | 1 |
p.D220N | UCEC | 1 |
p.P235S | SKCM | 1 |
Top |
TissGeneCNV for ASB9 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for ASB9 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | GBM | TCGA-06-2569-01A | WDR59-ASB9 | Out-of-frame | Chr16:74942806 | ChrX:15272966 |
TCGAfusionPortal | PRADA | LUAD | TCGA-78-7146-01A | TRIM41-ASB9 | Out-of-frame | Chr5:180651812 | ChrX:15277067 |
Top |
TissGeneNet for ASB9 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for ASB9 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for ASB9 |
TissGeneDrug for ASB9 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for ASB9 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |