TissGeneSummary for ACTRT2 |
Gene summary |
Basic gene information | Gene symbol | ACTRT2 |
Gene name | actin-related protein T2 | |
Synonyms | ARPM2|ARPT2|Arp-T2|HARPM2 | |
Cytomap | UCSC genome browser: 1p36.32 | |
Type of gene | protein-coding | |
RefGenes | NM_080431.4, | |
Description | actin-related protein M2actin-related protein hArpM2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608535 | |
HGNC : HGNC | ||
Ensembl : ENSG00000169717 | ||
HPRD : 12254 | ||
Vega : OTTHUMG00000000562 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACTRT2 | |
BioGPS: 140625 | ||
Pathway | NCI Pathway Interaction Database: ACTRT2 | |
KEGG: ACTRT2 | ||
REACTOME: ACTRT2 | ||
Pathway Commons: ACTRT2 | ||
Context | iHOP: ACTRT2 | |
ligand binding site mutation search in PubMed: ACTRT2 | ||
UCL Cancer Institute: ACTRT2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ACTRT2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACTRT2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ACTRT2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACTRT2 |
TissGeneSNV for ACTRT2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D214N | SKCM | 3 |
p.P205S | SKCM | 2 |
p.H183P | SKCM | 1 |
p.S340F | SKCM | 1 |
p.S353C | LUAD | 1 |
p.Q45* | LUAD | 1 |
p.A361T | STAD | 1 |
p.E76K | SKCM | 1 |
p.L295I | UCEC | 1 |
p.C21Y | STAD | 1 |
p.L295F | THYM | 1 |
p.P10Q | ESCA | 1 |
p.A199S | GBM | 1 |
p.A224T | THYM | 1 |
p.A185V | HNSC | 1 |
p.D246H | STAD | 1 |
p.R314Q | THYM | 1 |
p.Q373K | STAD | 1 |
p.L256M | LUAD | 1 |
p.Q53L | OV | 1 |
p.P335S | SKCM | 1 |
p.V39M | ESCA | 1 |
p.P168S | SKCM | 1 |
p.F128L | LUSC | 1 |
p.R374I | UCEC | 1 |
p.A333P | LUSC | 1 |
p.V184M | STAD | 1 |
p.P255T | LUAD | 1 |
p.Q267* | SKCM | 1 |
p.P274L | SKCM | 1 |
p.D336N | SKCM | 1 |
p.E241* | LUAD | 1 |
p.P274H | LUAD | 1 |
p.P134H | HNSC | 1 |
p.F131C | COAD | 1 |
p.A224V | SKCM | 1 |
p.D158N | SKCM | 1 |
p.G304S | HNSC | 1 |
p.S277L | STAD | 1 |
p.K365N | LUSC | 1 |
p.D85N | SKCM | 1 |
p.L69M | LUAD | 1 |
p.A142E | STAD | 1 |
p.G310V | BRCA | 1 |
p.D85E | LUAD | 1 |
p.E366D | UCEC | 1 |
p.A162V | STAD | 1 |
p.P4L | SKCM | 1 |
p.S139L | SKCM | 1 |
p.D140N | SKCM | 1 |
p.D312N | SKCM | 1 |
p.L193F | SKCM | 1 |
p.A145T | LUAD | 1 |
p.P334L | SKCM | 1 |
p.A148T | LGG | 1 |
p.R77H | STAD | 1 |
p.G186S | LGG | 1 |
p.S302L | STAD | 1 |
p.D8H | STAD | 1 |
p.G275R | GBM | 1 |
p.G27V | LUSC | 1 |
p.V348I | UCEC | 1 |
p.D246N | KIRC | 1 |
p.E261K | SKCM | 1 |
p.Y64H | LUAD | 1 |
p.D246N | UCEC | 1 |
p.L351V | BLCA | 1 |
p.D288N | HNSC | 1 |
p.Y137C | LUAD | 1 |
p.E237K | SKCM | 1 |
p.S232F | LIHC | 1 |
p.P134S | COAD | 1 |
p.G160R | BLCA | 1 |
p.S113F | SKCM | 1 |
p.K218Q | BLCA | 1 |
p.R314Q | STAD | 1 |
p.E118K | SKCM | 1 |
p.V371M | UCEC | 1 |
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TissGeneCNV for ACTRT2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACTRT2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ACTRT2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACTRT2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACTRT2 |
TissGeneDrug for ACTRT2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACTRT2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0022548 | Keloid | 1 | CTD_human |