TissGeneSummary for MROH8 |
Gene summary |
Basic gene information | Gene symbol | MROH8 |
Gene name | maestro heat-like repeat family member 8 | |
Synonyms | C20orf131|C20orf132|dJ621N11.3|dJ621N11.4 | |
Cytomap | UCSC genome browser: 20q11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_152503.5, NM_213631.2,NM_213632.2, | |
Description | maestro heat-like repeat-containing protein family member 8protein MROH8 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000101353 | ||
HPRD : 12745 | ||
Vega : OTTHUMG00000032407 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MROH8 | |
BioGPS: 140699 | ||
Pathway | NCI Pathway Interaction Database: MROH8 | |
KEGG: MROH8 | ||
REACTOME: MROH8 | ||
Pathway Commons: MROH8 | ||
Context | iHOP: MROH8 | |
ligand binding site mutation search in PubMed: MROH8 | ||
UCL Cancer Institute: MROH8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MROH8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MROH8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for MROH8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MROH8 |
TissGeneSNV for MROH8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G1038D | BLCA | 2 |
p.P962S | SKCM | 2 |
p.R746Q | HNSC | 1 |
p.E336Q | HNSC | 1 |
p.A590V | LIHC | 1 |
p.V503A | SKCM | 1 |
p.A661V | ESCA | 1 |
p.S103L | BLCA | 1 |
p.P96S | SKCM | 1 |
p.R852C | SKCM | 1 |
p.P642S | SKCM | 1 |
p.Q818H | LUAD | 1 |
p.G699E | CESC | 1 |
p.M835I | HNSC | 1 |
p.P327S | SKCM | 1 |
p.G729E | SKCM | 1 |
p.W912* | SKCM | 1 |
p.L668V | BLCA | 1 |
p.D803H | HNSC | 1 |
p.G1038D | PAAD | 1 |
p.N981S | MESO | 1 |
p.R365K | HNSC | 1 |
p.A1020V | HNSC | 1 |
p.M589I | LUAD | 1 |
p.V561M | LIHC | 1 |
p.R965K | SKCM | 1 |
p.A595S | LUAD | 1 |
p.E495K | BLCA | 1 |
p.E677K | SKCM | 1 |
p.R610Q | HNSC | 1 |
p.Q929* | PAAD | 1 |
p.P1004L | SKCM | 1 |
p.R610* | CESC | 1 |
p.V813I | ESCA | 1 |
p.S529F | HNSC | 1 |
p.R996T | LUAD | 1 |
p.E382K | SKCM | 1 |
p.T463A | LUAD | 1 |
p.G699R | SKCM | 1 |
p.E917Q | CESC | 1 |
p.L857V | CESC | 1 |
p.S841F | SKCM | 1 |
p.L419F | KIRC | 1 |
p.S101G | LIHC | 1 |
p.R610Q | SKCM | 1 |
p.G987S | SKCM | 1 |
p.E382A | SKCM | 1 |
p.P96L | SKCM | 1 |
p.A340P | LUAD | 1 |
p.R985G | LUAD | 1 |
p.M681I | SKCM | 1 |
p.M836I | BLCA | 1 |
p.E156K | CESC | 1 |
p.L415F | BLCA | 1 |
p.V877I | SKCM | 1 |
p.G739R | LUAD | 1 |
p.G692E | SKCM | 1 |
p.E810* | SKCM | 1 |
p.P868S | SKCM | 1 |
p.S155R | KIRP | 1 |
p.L725F | SKCM | 1 |
p.F450C | ESCA | 1 |
p.D893N | HNSC | 1 |
p.D379N | ACC | 1 |
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TissGeneCNV for MROH8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MROH8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MROH8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MROH8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MROH8 |
TissGeneDrug for MROH8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MROH8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |