TissGeneSummary for SUN5 |
Gene summary |
Basic gene information | Gene symbol | SUN5 |
Gene name | Sad1 and UNC84 domain containing 5 | |
Synonyms | SPAG4L|TSARG4|dJ726C3.1 | |
Cytomap | UCSC genome browser: 20q11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_080675.3, | |
Description | SUN domain-containing protein 5sad1 and UNC84 domain-containing protein 5sperm-associated antigen 4-like proteintestis and spermatogenesis related gene 4testis and spermatogenesis-related gene 4 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 613942 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167098 | ||
HPRD : 15422 | ||
Vega : OTTHUMG00000032239 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SUN5 | |
BioGPS: 140732 | ||
Pathway | NCI Pathway Interaction Database: SUN5 | |
KEGG: SUN5 | ||
REACTOME: SUN5 | ||
Pathway Commons: SUN5 | ||
Context | iHOP: SUN5 | |
ligand binding site mutation search in PubMed: SUN5 | ||
UCL Cancer Institute: SUN5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SUN5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SUN5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SUN5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SUN5 |
TissGeneSNV for SUN5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E154K | SKCM | 3 |
p.E195K | SKCM | 2 |
p.L289Q | BLCA | 1 |
p.V246M | CESC | 1 |
p.Q315* | SKCM | 1 |
p.T82S | COAD | 1 |
p.W346X | SKCM | 1 |
p.E195* | LUSC | 1 |
p.W346C | PRAD | 1 |
p.W226L | SKCM | 1 |
p.K202T | STAD | 1 |
p.M301I | KIRC | 1 |
p.W346* | SKCM | 1 |
p.T282I | UCEC | 1 |
p.R54H | COAD | 1 |
p.P365L | KIRC | 1 |
p.S161C | HNSC | 1 |
p.S344R | CESC | 1 |
p.R30* | UCEC | 1 |
p.E368K | SKCM | 1 |
p.V309L | LUAD | 1 |
p.P366T | ESCA | 1 |
p.F316L | SKCM | 1 |
p.V297F | BRCA | 1 |
p.N46_splice | LUSC | 1 |
p.R54C | STAD | 1 |
p.N163S | UCEC | 1 |
p.I107V | LUAD | 1 |
p.G205W | SKCM | 1 |
p.E171G | UCEC | 1 |
p.E171K | SKCM | 1 |
p.N245K | LUSC | 1 |
p.G249D | STAD | 1 |
p.E16K | SKCM | 1 |
p.P365T | LUAD | 1 |
p.R356H | UVM | 1 |
p.R149Q | UCEC | 1 |
p.Y144N | LUAD | 1 |
p.I189M | STAD | 1 |
p.V357M | CESC | 1 |
p.A332T | STAD | 1 |
p.A13T | KIRC | 1 |
p.R333L | UCEC | 1 |
p.C251F | READ | 1 |
p.L108V | HNSC | 1 |
p.R30Q | HNSC | 1 |
p.G347E | SKCM | 1 |
p.N348I | SKCM | 1 |
p.Q267* | CESC | 1 |
p.R149Q | COAD | 1 |
p.H190Q | LUSC | 1 |
p.T213M | COAD | 1 |
p.Q328H | STAD | 1 |
p.M301L | LIHC | 1 |
p.H219R | ESCA | 1 |
p.E39D | COAD | 1 |
p.R356H | COAD | 1 |
p.V359E | LUAD | 1 |
p.F118Y | SKCM | 1 |
p.G191R | SKCM | 1 |
p.Q183H | COAD | 1 |
p.G191E | SKCM | 1 |
p.P305S | SKCM | 1 |
p.V297A | LIHC | 1 |
p.Q99H | HNSC | 1 |
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TissGeneCNV for SUN5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SUN5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SUN5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SUN5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SUN5 |
TissGeneDrug for SUN5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SUN5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |