 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for RPL10L |
 Gene summary |
| Basic gene information | Gene symbol | RPL10L |
| Gene name | ribosomal protein L10-like | |
| Synonyms | RPL10_5_1358 | |
| Cytomap | UCSC genome browser: 14q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_080746.2, | |
| Description | 60S ribosomal protein L10-likeribosomal protein L10-like protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000165496 | ||
| HPRD : 11753 | ||
| Vega : OTTHUMG00000157869 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RPL10L | |
| BioGPS: 140801 | ||
| Pathway | NCI Pathway Interaction Database: RPL10L | |
| KEGG: RPL10L | ||
| REACTOME: RPL10L | ||
| Pathway Commons: RPL10L | ||
| Context | iHOP: RPL10L | |
| ligand binding site mutation search in PubMed: RPL10L | ||
| UCL Cancer Institute: RPL10L | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of RPL10L | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for RPL10L |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -0.811970571 | 1.880264044 | -2.692234615 | 5.85E-12 | 1.26E-10 |
| Top |
| TissGene-miRNA for RPL10L |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for RPL10L |
| TissGeneSNV for RPL10L |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E180K | STAD | 2 |
| p.E180K | SKCM | 2 |
| p.R162S | LUAD | 2 |
| p.R21C | SKCM | 2 |
| p.S20Y | UCEC | 1 |
| p.M115I | HNSC | 1 |
| p.R32C | UCEC | 1 |
| p.P18S | HNSC | 1 |
| p.N14K | STAD | 1 |
| p.R139S | THYM | 1 |
| p.E146D | UCEC | 1 |
| p.S79R | ESCA | 1 |
| p.S104Y | LUSC | 1 |
| p.G37S | STAD | 1 |
| p.R21C | UCEC | 1 |
| p.K74I | STAD | 1 |
| p.R4H | PRAD | 1 |
| p.Q59H | LUSC | 1 |
| p.K156R | STAD | 1 |
| p.G81C | LUSC | 1 |
| p.E145K | LUSC | 1 |
| p.E145K | SKCM | 1 |
| p.H203Y | SKCM | 1 |
| p.S137F | UCEC | 1 |
| p.G196A | LUAD | 1 |
| p.T125I | UCEC | 1 |
| p.G84V | LUAD | 1 |
| p.R4H | GBM | 1 |
| p.R162L | HNSC | 1 |
| p.R153H | HNSC | 1 |
| p.E145* | LUAD | 1 |
| p.K15R | ESCA | 1 |
| p.A67V | SKCM | 1 |
| p.L190P | LUAD | 1 |
| p.F94L | ESCA | 1 |
| p.G120R | SKCM | 1 |
| p.K187T | STAD | 1 |
| p.R38G | BRCA | 1 |
| p.R139H | COAD | 1 |
| p.Q143H | STAD | 1 |
| p.R116* | BLCA | 1 |
| p.M102V | HNSC | 1 |
| p.P93R | LUAD | 1 |
| p.N144K | LUAD | 1 |
| p.E182Q | BLCA | 1 |
| p.H95Y | SKCM | 1 |
| p.E56D | LUAD | 1 |
| p.G204D | THYM | 1 |
| p.R210Q | UCEC | 1 |
| p.P93L | SKCM | 1 |
| p.D44Y | PAAD | 1 |
| p.D193N | LUSC | 1 |
| p.P192S | SKCM | 1 |
| p.P122H | THYM | 1 |
| p.G50D | LIHC | 1 |
| p.F119L | PRAD | 1 |
| p.G124S | UCEC | 1 |
| p.R116P | ESCA | 1 |
| p.G2V | LUAD | 1 |
| p.R21H | STAD | 1 |
| p.A68T | OV | 1 |
| p.Q59H | STAD | 1 |
| p.R4S | LUSC | 1 |
| p.K187R | ESCA | 1 |
| p.R162C | LGG | 1 |
| p.R153H | PAAD | 1 |
| p.R90Q | SARC | 1 |
| p.K170T | STAD | 1 |
| p.R7C | SKCM | 1 |
| p.P47L | STAD | 1 |
| p.K198T | STAD | 1 |
| p.K30N | HNSC | 1 |
| p.H92N | LUAD | 1 |
| p.R90Q | STAD | 1 |
| p.T113A | LUAD | 1 |
| p.G50S | BRCA | 1 |
| p.T125A | STAD | 1 |
| p.D109H | LUSC | 1 |
| p.Y199* | LUAD | 1 |
| Top |
| TissGeneCNV for RPL10L |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for RPL10L |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for RPL10L |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (tumor) | RPL10L, CAND1, UBC, KIAA0101, CUL1, COPS5, MAP3K14, PCK1 (normal) |
 |  |
| Top |
| TissGeneProg for RPL10L |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for RPL10L |
| TissGeneDrug for RPL10L |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for RPL10L |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |