TissGeneSummary for KRT72 |
Gene summary |
Basic gene information | Gene symbol | KRT72 |
Gene name | keratin 72 | |
Synonyms | K6IRS2|K6irs|KRT6|KRT6IRS2 | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001146225.1, NM_001146226.1,NM_080747.2, | |
Description | CK-72K72cytokeratin-72keratin 6, inner root sheath, 2keratin protein K6irskeratin, type II cytoskeletal 72keratin-72type II inner root sheath-specific keratin-K6irs2type-II keratin Kb35 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608246 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170486 | ||
HPRD : 09746 | ||
Vega : OTTHUMG00000169744 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT72 | |
BioGPS: 140807 | ||
Pathway | NCI Pathway Interaction Database: KRT72 | |
KEGG: KRT72 | ||
REACTOME: KRT72 | ||
Pathway Commons: KRT72 | ||
Context | iHOP: KRT72 | |
ligand binding site mutation search in PubMed: KRT72 | ||
UCL Cancer Institute: KRT72 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KRT72 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KRT72 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for KRT72 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT72 |
TissGeneSNV for KRT72 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P98S | SKCM | 1 |
p.P89L | SKCM | 1 |
p.Y318N | SKCM | 1 |
p.E441K | ACC | 1 |
p.K434N | COAD | 1 |
p.H355Q | SKCM | 1 |
p.G352S | SKCM | 1 |
p.A328V | COAD | 1 |
p.G194R | DLBC | 1 |
p.A374V | SKCM | 1 |
p.G378R | OV | 1 |
p.E228A | LUAD | 1 |
p.E441K | SKCM | 1 |
p.E298K | UCEC | 1 |
p.S403F | SKCM | 1 |
p.I175T | STAD | 1 |
p.T369M | BLCA | 1 |
p.G76A | SKCM | 1 |
p.S445F | SKCM | 1 |
p.G333V | PRAD | 1 |
p.V414M | OV | 1 |
p.D285N | HNSC | 1 |
p.D210N | LUAD | 1 |
p.R37Q | DLBC | 1 |
p.H397Q | SKCM | 1 |
p.G73S | COAD | 1 |
p.E399K | ACC | 1 |
p.R377Q | PRAD | 1 |
p.R408H | BRCA | 1 |
p.E375K | BLCA | 1 |
p.K213N | COAD | 1 |
p.R428S | LUAD | 1 |
p.R428C | STAD | 1 |
p.A381T | STAD | 1 |
p.K400N | LUSC | 1 |
p.S199L | STAD | 1 |
p.N220Y | LUAD | 1 |
p.S355* | BLCA | 1 |
p.L207M | SKCM | 1 |
p.K258E | HNSC | 1 |
p.P109T | LUAD | 1 |
p.D206N | SKCM | 1 |
p.D337N | COAD | 1 |
p.R354C | UVM | 1 |
p.K507Q | STAD | 1 |
p.A427T | COAD | 1 |
p.S453I | HNSC | 1 |
p.A395T | PCPG | 1 |
p.E356* | LUAD | 1 |
p.E432Q | LUAD | 1 |
p.T369M | UCEC | 1 |
p.R196M | UCEC | 1 |
p.S276N | ESCA | 1 |
p.A372T | STAD | 1 |
p.K383Q | OV | 1 |
p.S20P | PRAD | 1 |
p.T339N | OV | 1 |
p.A224S | STAD | 1 |
p.E399K | SKCM | 1 |
p.L325R | LUAD | 1 |
p.R386Q | STAD | 1 |
p.E315X | KIRP | 1 |
p.L350R | SKCM | 1 |
p.M241I | LUAD | 1 |
p.K362T | ESCA | 1 |
p.E441K | SARC | 1 |
p.A297V | COAD | 1 |
p.I268S | UCS | 1 |
p.G486A | LUSC | 1 |
p.L392R | SKCM | 1 |
p.A469S | LIHC | 1 |
p.E324D | LUAD | 1 |
p.D324E | COAD | 1 |
p.G457W | LIHC | 1 |
p.D342N | SKCM | 1 |
p.F463L | LIHC | 1 |
p.V152A | LUSC | 1 |
p.G394S | SKCM | 1 |
p.R408H | STAD | 1 |
p.G489V | STAD | 1 |
p.E173* | LUSC | 1 |
p.Q323X | ESCA | 1 |
p.D293E | LUAD | 1 |
p.D198N | BRCA | 1 |
p.Q323* | ESCA | 1 |
p.A374D | LUAD | 1 |
p.D384N | SKCM | 1 |
p.A419T | STAD | 1 |
p.R428C | LIHC | 1 |
p.Q331H | UCEC | 1 |
p.R122C | UCEC | 1 |
p.E117K | UCEC | 1 |
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TissGeneCNV for KRT72 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT72 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KRT72 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT72 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT72 |
TissGeneDrug for KRT72 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT72 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0553723 | Squamous cell carcinoma of skin | 1 | BeFree |