TissGeneSummary for ZNF280B |
Gene summary |
Basic gene information | Gene symbol | ZNF280B |
Gene name | zinc finger protein 280B | |
Synonyms | 5'OY11.1|D87009.C22.3|SUHW2|ZNF279|ZNF632 | |
Cytomap | UCSC genome browser: 22q11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_080764.2, | |
Description | suppressor of hairy wing homolog 2zinc finger protein 279zinc finger protein 632 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000275004 | ||
HPRD : 11615 | ||
Vega : OTTHUMG00000151066 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF280B | |
BioGPS: 140883 | ||
Pathway | NCI Pathway Interaction Database: ZNF280B | |
KEGG: ZNF280B | ||
REACTOME: ZNF280B | ||
Pathway Commons: ZNF280B | ||
Context | iHOP: ZNF280B | |
ligand binding site mutation search in PubMed: ZNF280B | ||
UCL Cancer Institute: ZNF280B | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
Reference showing the relevant tissue of ZNF280B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZNF280B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.596912432 | -1.810017605 | 1.213105172 | 1.94E-06 | 6.21E-06 |
LUSC | -0.430693264 | -1.823524636 | 1.392831373 | 1.15E-05 | 2.59E-05 |
KIRP | -0.565886462 | -1.725330212 | 1.15944375 | 3.56E-05 | 0.000134143 |
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TissGene-miRNA for ZNF280B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-let-7a-5p | MIMAT0000062 | 0.036 | -0.27 | 60 |
UCS | hsa-miR-106a-5p | MIMAT0000103 | 0.047 | -0.27 | 56 |
LUAD | hsa-let-7f-5p | MIMAT0000067 | 0.027 | -0.29 | 60 |
UCS | hsa-miR-96-5p | MIMAT0000095 | 0.032 | -0.29 | 56 |
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TissGeneMut for ZNF280B |
TissGeneSNV for ZNF280B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E400K | GBM | 2 |
p.K317R | STAD | 1 |
p.E19G | HNSC | 1 |
p.L265F | LUSC | 1 |
p.Q484* | BRCA | 1 |
p.H460Q | THYM | 1 |
p.P144S | SKCM | 1 |
p.A188D | SARC | 1 |
p.E108Q | LUSC | 1 |
p.D76V | LIHC | 1 |
p.N280S | STAD | 1 |
p.N184H | COAD | 1 |
p.K241E | LUAD | 1 |
p.T177S | HNSC | 1 |
p.P218L | LUAD | 1 |
p.V414I | DLBC | 1 |
p.R187G | LUAD | 1 |
p.G513V | LIHC | 1 |
p.Q386* | LUAD | 1 |
p.N166H | COAD | 1 |
p.S53L | BLCA | 1 |
p.S58A | KIRP | 1 |
p.D27H | HNSC | 1 |
p.N318T | STAD | 1 |
p.F469C | CESC | 1 |
p.E400K | COAD | 1 |
p.H421Y | BRCA | 1 |
p.L470V | UCEC | 1 |
p.W339F | LUAD | 1 |
p.A201D | ESCA | 1 |
p.T224I | SKCM | 1 |
p.V57L | HNSC | 1 |
p.W339L | LUAD | 1 |
p.V365G | UCEC | 1 |
p.V374L | KIRC | 1 |
p.E400K | CESC | 1 |
p.P144L | SKCM | 1 |
p.G291R | TGCT | 1 |
p.E400K | BLCA | 1 |
p.R191S | LUSC | 1 |
p.Y447C | LGG | 1 |
p.V229L | LUAD | 1 |
p.R411I | LIHC | 1 |
p.Q230E | HNSC | 1 |
p.E400K | UCEC | 1 |
p.H209D | LUAD | 1 |
p.G513E | KIRC | 1 |
p.W339C | LUAD | 1 |
p.G232V | STAD | 1 |
p.V49M | COAD | 1 |
p.D526V | STAD | 1 |
p.P532L | SKCM | 1 |
p.R187G | HNSC | 1 |
p.E196K | SKCM | 1 |
p.H37N | HNSC | 1 |
p.V501F | LUAD | 1 |
p.I45M | BRCA | 1 |
p.P234L | SKCM | 1 |
p.P281L | LIHC | 1 |
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TissGeneCNV for ZNF280B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZNF280B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ZNF280B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZNF280B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZNF280B |
TissGeneDrug for ZNF280B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZNF280B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033578 | Prostatic Neoplasms | 1 | GAD |