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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CRYBB2
check button Gene summary
Basic gene informationGene symbolCRYBB2
Gene namecrystallin, beta B2
SynonymsCCA2|CRYB2|CRYB2A|CTRCT3|D22S665
CytomapUCSC genome browser: 22q11.23
Type of geneprotein-coding
RefGenesNM_000496.2,
Descriptionbeta-B2 crystallinbeta-crystallin B2beta-crystallin Bpeye lens structural protein
Modification date20141222
dbXrefs MIM : 123620
HGNC : HGNC
Ensembl : ENSG00000244752
HPRD : 00430
Vega : OTTHUMG00000150905
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CRYBB2
BioGPS: 1415
PathwayNCI Pathway Interaction Database: CRYBB2
KEGG: CRYBB2
REACTOME: CRYBB2
Pathway Commons: CRYBB2
ContextiHOP: CRYBB2
ligand binding site mutation search in PubMed: CRYBB2
UCL Cancer Institute: CRYBB2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)TestisEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCTUVM
Reference showing the relevant tissue of CRYBB2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CRYBB2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for CRYBB2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CRYBB2
TissGeneSNV for CRYBB2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R191CSTAD2
p.E43KSKCM2
p.D176NSKCM1
p.R145WPAAD1
p.W82*SKCM1
p.G57RSKCM1
p.K108NUCEC1
p.T150MLGG1
p.G169RSKCM1
p.R145PLUAD1
p.P182LSKCM1
p.T91MLUAD1
p.L97MSKCM1
p.R90KSKCM1
p.A179DLUAD1
p.D4EKIRC1
p.R89QSKCM1
p.S31LSKCM1
p.R160CGBM1
p.G69SSKCM1
p.C67SUCEC1
p.G57ESKCM1
p.S142LSKCM1
p.R89*BLCA1
p.L15ISTAD1
p.R189LLUSC1
p.R145QUCEC1
p.R191HPAAD1
p.V141MSKCM1
p.P203LSKCM1
p.Y159NLIHC1
p.A179SPRAD1
p.P115SSKCM1
p.S95ILUAD1


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TissGeneCNV for CRYBB2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CRYBB2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABU734913CRYBB2-FAHchr22:25627836chr15:80464543
Chimerdb3.0ChiTaRsNABM712054CRYBB2-SHBchr22:25620974chr9:37919775
Chimerdb3.0FusionScanLGGTCGA-HT-A74H-01AZNRF3-CRYBB25'UTR-5'UTRchr22:29280054chr22:25617370


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TissGeneNet for CRYBB2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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COAD (tumor)COAD (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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HNSC (tumor)HNSC (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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KICH (tumor)KICH (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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KIRC (tumor)KIRC (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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KIRP (tumor)KIRP (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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LIHC (tumor)LIHC (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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LUAD (tumor)LUAD (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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LUSC (tumor)LUSC (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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PRAD (tumor)PRAD (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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STAD (tumor)STAD (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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THCA (tumor)THCA (normal)
CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (tumor)CRYBB2, CRYBA1, CRYBA2, CRYAB, HSPB1, CRYAA, CRYGC, CRYBA4 (normal)
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TissGeneProg for CRYBB2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CRYBB2
TissGeneDrug for CRYBB2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CRYBB2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0086543Cataract14BeFree,LHGDN
umls:C0009691Congenital cataract10BeFree
umls:C0521707Bilateral cataracts (disorder)5BeFree
umls:C1858679CATARACT, AUTOSOMAL DOMINANT3BeFree
umls:C0042164Uveitis2CTD_human
umls:C0344523Cataract, congenital, cerulean type 12BeFree,CTD_human,ORPHANET
umls:C1510497Lens Opacities2BeFree
umls:C0004364Autoimmune Diseases1CTD_human
umls:C0026010Microphthalmos1BeFree
umls:C0206743Rhabdoid Tumor1BeFree
umls:C0266544Microcornea1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0392557Nuclear cataract1BeFree,ORPHANET
umls:C0600139Prostate carcinoma1BeFree
umls:C1112705Nuclear non-senile cataract1BeFree,ORPHANET
umls:C0266539Congenital total cataract0ORPHANET
umls:C1832175Cataract, Congenital, Cerulean Type, 20CLINVAR,CTD_human,MGD
umls:C1852438CATARACT, COPPOCK-LIKE0CTD_human
umls:C1861829Cataract microcornea syndrome0ORPHANET