TissGeneSummary for CRYBB2 |
Gene summary |
Basic gene information | Gene symbol | CRYBB2 |
Gene name | crystallin, beta B2 | |
Synonyms | CCA2|CRYB2|CRYB2A|CTRCT3|D22S665 | |
Cytomap | UCSC genome browser: 22q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_000496.2, | |
Description | beta-B2 crystallinbeta-crystallin B2beta-crystallin Bpeye lens structural protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 123620 | |
HGNC : HGNC | ||
Ensembl : ENSG00000244752 | ||
HPRD : 00430 | ||
Vega : OTTHUMG00000150905 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CRYBB2 | |
BioGPS: 1415 | ||
Pathway | NCI Pathway Interaction Database: CRYBB2 | |
KEGG: CRYBB2 | ||
REACTOME: CRYBB2 | ||
Pathway Commons: CRYBB2 | ||
Context | iHOP: CRYBB2 | |
ligand binding site mutation search in PubMed: CRYBB2 | ||
UCL Cancer Institute: CRYBB2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of CRYBB2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CRYBB2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CRYBB2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CRYBB2 |
TissGeneSNV for CRYBB2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R191C | STAD | 2 |
p.E43K | SKCM | 2 |
p.D176N | SKCM | 1 |
p.R145W | PAAD | 1 |
p.W82* | SKCM | 1 |
p.G57R | SKCM | 1 |
p.K108N | UCEC | 1 |
p.T150M | LGG | 1 |
p.G169R | SKCM | 1 |
p.R145P | LUAD | 1 |
p.P182L | SKCM | 1 |
p.T91M | LUAD | 1 |
p.L97M | SKCM | 1 |
p.R90K | SKCM | 1 |
p.A179D | LUAD | 1 |
p.D4E | KIRC | 1 |
p.R89Q | SKCM | 1 |
p.S31L | SKCM | 1 |
p.R160C | GBM | 1 |
p.G69S | SKCM | 1 |
p.C67S | UCEC | 1 |
p.G57E | SKCM | 1 |
p.S142L | SKCM | 1 |
p.R89* | BLCA | 1 |
p.L15I | STAD | 1 |
p.R189L | LUSC | 1 |
p.R145Q | UCEC | 1 |
p.R191H | PAAD | 1 |
p.V141M | SKCM | 1 |
p.P203L | SKCM | 1 |
p.Y159N | LIHC | 1 |
p.A179S | PRAD | 1 |
p.P115S | SKCM | 1 |
p.S95I | LUAD | 1 |
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TissGeneCNV for CRYBB2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CRYBB2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU734913 | CRYBB2-FAH | chr22:25627836 | chr15:80464543 | |
Chimerdb3.0 | ChiTaRs | NA | BM712054 | CRYBB2-SHB | chr22:25620974 | chr9:37919775 | |
Chimerdb3.0 | FusionScan | LGG | TCGA-HT-A74H-01A | ZNRF3-CRYBB2 | 5'UTR-5'UTR | chr22:29280054 | chr22:25617370 |
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TissGeneNet for CRYBB2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CRYBB2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CRYBB2 |
TissGeneDrug for CRYBB2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CRYBB2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0086543 | Cataract | 14 | BeFree,LHGDN |
umls:C0009691 | Congenital cataract | 10 | BeFree |
umls:C0521707 | Bilateral cataracts (disorder) | 5 | BeFree |
umls:C1858679 | CATARACT, AUTOSOMAL DOMINANT | 3 | BeFree |
umls:C0042164 | Uveitis | 2 | CTD_human |
umls:C0344523 | Cataract, congenital, cerulean type 1 | 2 | BeFree,CTD_human,ORPHANET |
umls:C1510497 | Lens Opacities | 2 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | CTD_human |
umls:C0026010 | Microphthalmos | 1 | BeFree |
umls:C0206743 | Rhabdoid Tumor | 1 | BeFree |
umls:C0266544 | Microcornea | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0392557 | Nuclear cataract | 1 | BeFree,ORPHANET |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C1112705 | Nuclear non-senile cataract | 1 | BeFree,ORPHANET |
umls:C0266539 | Congenital total cataract | 0 | ORPHANET |
umls:C1832175 | Cataract, Congenital, Cerulean Type, 2 | 0 | CLINVAR,CTD_human,MGD |
umls:C1852438 | CATARACT, COPPOCK-LIKE | 0 | CTD_human |
umls:C1861829 | Cataract microcornea syndrome | 0 | ORPHANET |