 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CRYGD |
 Gene summary |
| Basic gene information | Gene symbol | CRYGD |
| Gene name | crystallin, gamma D | |
| Synonyms | CACA|CCA3|CCP|CRYG4|CTRCT4|PCC|cry-g-D | |
| Cytomap | UCSC genome browser: 2q33.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006891.3, | |
| Description | gamma crystallin 4gamma-D-crystallingamma-crystallin 4gamma-crystallin D | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 123690 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118231 | ||
| HPRD : 00436 | ||
| Vega : OTTHUMG00000132944 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CRYGD | |
| BioGPS: 1421 | ||
| Pathway | NCI Pathway Interaction Database: CRYGD | |
| KEGG: CRYGD | ||
| REACTOME: CRYGD | ||
| Pathway Commons: CRYGD | ||
| Context | iHOP: CRYGD | |
| ligand binding site mutation search in PubMed: CRYGD | ||
| UCL Cancer Institute: CRYGD | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVUVM | |
| Reference showing the relevant tissue of CRYGD | Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Lengler J, Krausz E, Tomarev S, Prescott A, Quinlan RA, Graw J. Nucleic Acids Res. 2001 Jan 15;29(2):515-26. (pmid:11139622) go to article | |
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0034614 | cellular response to reactive oxygen species | 8943244 | GO:0034614 | cellular response to reactive oxygen species | 8943244 |
| Top |
| TissGeneExp for CRYGD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for CRYGD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for CRYGD |
| TissGeneSNV for CRYGD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A36V | KIRP | 2 |
| p.A36V | PAAD | 2 |
| p.D74N | STAD | 1 |
| p.R152M | SARC | 1 |
| p.R115H | PAAD | 1 |
| p.Q77K | LUSC | 1 |
| p.S40R | LUSC | 1 |
| p.D108Y | LUAD | 1 |
| p.H122Y | SKCM | 1 |
| p.A36V | LIHC | 1 |
| p.W131* | BLCA | 1 |
| p.R140Q | HNSC | 1 |
| p.S137P | HNSC | 1 |
| p.G149E | SKCM | 1 |
| p.G41R | PAAD | 1 |
| p.S78Y | LUAD | 1 |
| p.N125K | LUSC | 1 |
| p.Y134* | LIHC | 1 |
| p.R117G | ESCA | 1 |
| p.R117H | UCEC | 1 |
| p.E120G | PRAD | 1 |
| p.I171M | LUAD | 1 |
| p.S174T | LUAD | 1 |
| p.L6P | SKCM | 1 |
| p.R142Q | LUSC | 1 |
| p.D150E | GBM | 1 |
| p.S52W | MESO | 1 |
| p.Y134X | LIHC | 1 |
| p.E128K | SKCM | 1 |
| p.D65N | STAD | 1 |
| Top |
| TissGeneCNV for CRYGD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CRYGD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for CRYGD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for CRYGD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CRYGD |
| TissGeneDrug for CRYGD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for CRYGD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003873 | Rheumatoid Arthritis | 81 | BeFree |
| umls:C0086543 | Cataract | 26 | BeFree,CTD_human,LHGDN |
| umls:C0009691 | Congenital cataract | 8 | BeFree |
| umls:C0003864 | Arthritis | 6 | BeFree |
| umls:C0031511 | Pheochromocytoma | 6 | BeFree |
| umls:C3540850 | CATARACT 4, MULTIPLE TYPES | 6 | CTD_human,MGD,UNIPROT |
| umls:C0521707 | Bilateral cataracts (disorder) | 5 | BeFree |
| umls:C0025268 | Multiple Endocrine Neoplasia Type 2a | 4 | BeFree |
| umls:C0030421 | Paraganglioma | 4 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0268579 | Propionic acidemia | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C1861832 | CATARACT, CRYSTALLINE ACULEIFORM | 3 | BeFree |
| umls:C0003872 | Arthritis, Psoriatic | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0008626 | Congenital chromosomal disease | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0162323 | Polyarthritis | 2 | BeFree |
| umls:C0302254 | Juvenile cataract | 2 | BeFree |
| umls:C0333307 | Superficial ulcer | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C1692871 | Inflammatory polyarthritis | 2 | BeFree |
| umls:C3714757 | Juvenile rheumatoid arthritis | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0010403 | Cryoglobulinemia | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0017563 | Gingival Diseases | 1 | BeFree |
| umls:C0019562 | Von Hippel-Lindau Syndrome | 1 | BeFree |
| umls:C0022408 | Arthropathy | 1 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | BeFree |
| umls:C0027697 | Nephritis | 1 | BeFree |
| umls:C0031090 | Periodontal Diseases | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | BeFree |
| umls:C0035435 | Rheumatism | 1 | BeFree |
| umls:C0036646 | Age-related cataract | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0039103 | Synovitis | 1 | BeFree |
| umls:C0085574 | Palindromic rheumatism | 1 | BeFree |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0152031 | Joint swelling | 1 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0260037 | Multiple tumors | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0392514 | Hereditary hemochromatosis | 1 | BeFree |
| umls:C0409679 | Seronegative arthritis | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0543697 | Mixed cryoglobulinemia | 1 | BeFree |
| umls:C0949690 | Spondylarthritis | 1 | BeFree |
| umls:C1510497 | Lens Opacities | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1832526 | CATARACT, NONNUCLEAR POLYMORPHIC CONGENITAL, AUTOSOMAL DOMINANT | 1 | BeFree |
| umls:C1858592 | Carney Triad | 1 | BeFree |
| umls:C3495559 | Juvenile arthritis | 1 | BeFree |
| umls:C0344523 | Cataract, congenital, cerulean type 1 | 0 | ORPHANET |
| umls:C0392557 | Nuclear cataract | 0 | ORPHANET |
| umls:C1112705 | Nuclear non-senile cataract | 0 | ORPHANET |
| umls:C1852438 | CATARACT, COPPOCK-LIKE | 0 | MGD |
| umls:C1861829 | Cataract microcornea syndrome | 0 | ORPHANET |
| umls:C3805409 | CATARACT 29 | 0 | ORPHANET |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |