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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CRYZ
check button Gene summary
Basic gene informationGene symbolCRYZ
Gene namecrystallin, zeta (quinone reductase)
Synonyms-
CytomapUCSC genome browser: 1p31.1
Type of geneprotein-coding
RefGenesNM_001130042.1,
NM_001130043.1,NM_001134759.1,NM_001889.3,
DescriptionNADPH:quinone reductasequinone oxidoreductase
Modification date20141207
dbXrefs MIM : 123691
HGNC : HGNC
Ensembl : ENSG00000116791
HPRD : 00437
Vega : OTTHUMG00000009620
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CRYZ
BioGPS: 1429
PathwayNCI Pathway Interaction Database: CRYZ
KEGG: CRYZ
REACTOME: CRYZ
Pathway Commons: CRYZ
ContextiHOP: CRYZ
ligand binding site mutation search in PubMed: CRYZ
UCL Cancer Institute: CRYZ
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of CRYZ
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0042178xenobiotic catabolic process17497241
GO:0042178xenobiotic catabolic process17497241


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TissGeneExp for CRYZ

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH0.227741422.69995342-2.4722127.48E-104.83E-09


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TissGene-miRNA for CRYZ

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CRYZ
TissGeneSNV for CRYZ

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P49LSKCM2
p.G163SSKCM1
p.I252FHNSC1
p.K89NESCA1
p.L190FSKCM1
p.S136FSKCM1
p.V298MSTAD1
p.Q281*UCEC1
p.R55CSKCM1
p.R242*HNSC1
p.D35YREAD1
p.G300SSKCM1
p.G103RCOAD1
p.G214SLUAD1
p.V50MSTAD1
p.L327IUCEC1
p.A127SLUAD1
p.R138XREAD1
p.G162ELUAD1
p.M188ICOAD1
p.M260IKIRC1
p.I84TSKCM1
p.D207NBLCA1
p.K89NLUSC1
p.I221TSKCM1
p.A169DSTAD1
p.P31LUCEC1
p.E306KCESC1
p.G102VLUSC1
p.L327FSKCM1
p.F16CREAD1
p.E183KDLBC1
p.R138LBLCA1
p.L230RLUAD1
p.P63SSTAD1
p.I39VCOAD1
p.S273FSKCM1
p.L163*LUAD1


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TissGeneCNV for CRYZ

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CRYZ

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAI910757MGST1-CRYZchr12:16517339chr1:75172662
Chimerdb3.0FusionScanESCATCGA-Z6-AAPN-01ATYW3-CRYZ5'UTR-5'UTRchr1:75199102chr1:75199092
Chimerdb3.0FusionScanESCATCGA-IG-A3I8-11ATYW3-CRYZ5'UTR-5'UTRchr1:75199102chr1:75199092
TCGAfusionPortalPRADASKCMTCGA-EB-A551-01ASPATA6-CRYZCDS-5UTRChr1:48937630Chr1:75190518


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TissGeneNet for CRYZ

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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COAD (tumor)COAD (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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HNSC (tumor)HNSC (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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KICH (tumor)KICH (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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KIRC (tumor)KIRC (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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KIRP (tumor)KIRP (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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LIHC (tumor)LIHC (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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LUAD (tumor)LUAD (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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LUSC (tumor)LUSC (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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PRAD (tumor)PRAD (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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STAD (tumor)STAD (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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THCA (tumor)THCA (normal)
CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (tumor)CRYZ, IKBKE, HNF4A, MCC, CBX5, CRYAA (normal)
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TissGeneProg for CRYZ

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CRYZ
TissGeneDrug for CRYZ

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00266DicoumarolInhibitorSmall moleculeApproved


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TissGeneDisease for CRYZ

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0242379Malignant neoplasm of lung14BeFree
umls:C0684249Carcinoma of lung14BeFree
umls:C0005684Malignant neoplasm of urinary bladder8BeFree
umls:C1527249Colorectal Cancer8BeFree
umls:C0009402Colorectal Carcinoma7BeFree
umls:C0023449Acute lymphocytic leukemia7BeFree
umls:C0699790Colon Carcinoma7BeFree
umls:C0699885Carcinoma of bladder7BeFree
umls:C2239176Liver carcinoma7BeFree
umls:C0023467Leukemia, Myelocytic, Acute6BeFree
umls:C0596263Carcinogenesis6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0023903Liver neoplasms5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0007102Malignant tumor of colon4BeFree
umls:C0007131Non-Small Cell Lung Carcinoma4BeFree
umls:C0023418leukemia4BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma4BeFree
umls:C0036341Schizophrenia3BeFree
umls:C0149925Small cell carcinoma of lung3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0001418Adenocarcinoma2BeFree
umls:C0004096Asthma2BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree
umls:C0022116Ischemia2BeFree
umls:C0024299Lymphoma2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0026764Multiple Myeloma2BeFree
umls:C0027022Myeloproliferative disease2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0086543Cataract2BeFree
umls:C0152115Lingual-Facial-Buccal Dyskinesia2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0264408Childhood asthma2BeFree
umls:C0278704Malignant Childhood Neoplasm2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site2BeFree
umls:C0686347Tardive Dyskinesia2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0858970Carcinogenicity2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C0002895Anemia, Sickle Cell1BeFree
umls:C0004763Barrett Esophagus1BeFree
umls:C0007112Adenocarcinoma of prostate1BeFree
umls:C0007114Malignant neoplasm of skin1BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0009691Congenital cataract1BeFree
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0014859Esophageal Neoplasms1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0025202melanoma1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0030567Parkinson Disease1GAD
umls:C0085669Acute leukemia1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0279628Adenocarcinoma Of Esophagus1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0333186Restenosis1BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0432412Chromosome 8, trisomy1BeFree
umls:C0521707Bilateral cataracts (disorder)1BeFree
umls:C0525045Mood Disorders1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C0750952Biliary Tract Cancer1BeFree
umls:C0751651Mitochondrial Diseases1BeFree
umls:C0917796Optic Atrophy, Hereditary, Leber1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1BeFree