TissGeneSummary for CRYZ |
Gene summary |
Basic gene information | Gene symbol | CRYZ |
Gene name | crystallin, zeta (quinone reductase) | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1p31.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001130042.1, NM_001130043.1,NM_001134759.1,NM_001889.3, | |
Description | NADPH:quinone reductasequinone oxidoreductase | |
Modification date | 20141207 | |
dbXrefs | MIM : 123691 | |
HGNC : HGNC | ||
Ensembl : ENSG00000116791 | ||
HPRD : 00437 | ||
Vega : OTTHUMG00000009620 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CRYZ | |
BioGPS: 1429 | ||
Pathway | NCI Pathway Interaction Database: CRYZ | |
KEGG: CRYZ | ||
REACTOME: CRYZ | ||
Pathway Commons: CRYZ | ||
Context | iHOP: CRYZ | |
ligand binding site mutation search in PubMed: CRYZ | ||
UCL Cancer Institute: CRYZ | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of CRYZ | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0042178 | xenobiotic catabolic process | 17497241 | GO:0042178 | xenobiotic catabolic process | 17497241 |
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TissGeneExp for CRYZ |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 0.22774142 | 2.69995342 | -2.472212 | 7.48E-10 | 4.83E-09 |
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TissGene-miRNA for CRYZ |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CRYZ |
TissGeneSNV for CRYZ |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P49L | SKCM | 2 |
p.G163S | SKCM | 1 |
p.I252F | HNSC | 1 |
p.K89N | ESCA | 1 |
p.L190F | SKCM | 1 |
p.S136F | SKCM | 1 |
p.V298M | STAD | 1 |
p.Q281* | UCEC | 1 |
p.R55C | SKCM | 1 |
p.R242* | HNSC | 1 |
p.D35Y | READ | 1 |
p.G300S | SKCM | 1 |
p.G103R | COAD | 1 |
p.G214S | LUAD | 1 |
p.V50M | STAD | 1 |
p.L327I | UCEC | 1 |
p.A127S | LUAD | 1 |
p.R138X | READ | 1 |
p.G162E | LUAD | 1 |
p.M188I | COAD | 1 |
p.M260I | KIRC | 1 |
p.I84T | SKCM | 1 |
p.D207N | BLCA | 1 |
p.K89N | LUSC | 1 |
p.I221T | SKCM | 1 |
p.A169D | STAD | 1 |
p.P31L | UCEC | 1 |
p.E306K | CESC | 1 |
p.G102V | LUSC | 1 |
p.L327F | SKCM | 1 |
p.F16C | READ | 1 |
p.E183K | DLBC | 1 |
p.R138L | BLCA | 1 |
p.L230R | LUAD | 1 |
p.P63S | STAD | 1 |
p.I39V | COAD | 1 |
p.S273F | SKCM | 1 |
p.L163* | LUAD | 1 |
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TissGeneCNV for CRYZ |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CRYZ |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI910757 | MGST1-CRYZ | chr12:16517339 | chr1:75172662 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-Z6-AAPN-01A | TYW3-CRYZ | 5'UTR-5'UTR | chr1:75199102 | chr1:75199092 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A3I8-11A | TYW3-CRYZ | 5'UTR-5'UTR | chr1:75199102 | chr1:75199092 |
TCGAfusionPortal | PRADA | SKCM | TCGA-EB-A551-01A | SPATA6-CRYZ | CDS-5UTR | Chr1:48937630 | Chr1:75190518 |
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TissGeneNet for CRYZ |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CRYZ |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CRYZ |
TissGeneDrug for CRYZ |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00266 | Dicoumarol | Inhibitor | Small molecule | Approved |
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TissGeneDisease for CRYZ |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242379 | Malignant neoplasm of lung | 14 | BeFree |
umls:C0684249 | Carcinoma of lung | 14 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 8 | BeFree |
umls:C1527249 | Colorectal Cancer | 8 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 7 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 7 | BeFree |
umls:C0699790 | Colon Carcinoma | 7 | BeFree |
umls:C0699885 | Carcinoma of bladder | 7 | BeFree |
umls:C2239176 | Liver carcinoma | 7 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 6 | BeFree |
umls:C0596263 | Carcinogenesis | 6 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0023903 | Liver neoplasms | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 5 | BeFree |
umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
umls:C0023418 | leukemia | 4 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 4 | BeFree |
umls:C0036341 | Schizophrenia | 3 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0004096 | Asthma | 2 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
umls:C0022116 | Ischemia | 2 | BeFree |
umls:C0024299 | Lymphoma | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0026764 | Multiple Myeloma | 2 | BeFree |
umls:C0027022 | Myeloproliferative disease | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0086543 | Cataract | 2 | BeFree |
umls:C0152115 | Lingual-Facial-Buccal Dyskinesia | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0264408 | Childhood asthma | 2 | BeFree |
umls:C0278704 | Malignant Childhood Neoplasm | 2 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 2 | BeFree |
umls:C0686347 | Tardive Dyskinesia | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0858970 | Carcinogenicity | 2 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
umls:C0002895 | Anemia, Sickle Cell | 1 | BeFree |
umls:C0004763 | Barrett Esophagus | 1 | BeFree |
umls:C0007112 | Adenocarcinoma of prostate | 1 | BeFree |
umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0009691 | Congenital cataract | 1 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0333186 | Restenosis | 1 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
umls:C0432412 | Chromosome 8, trisomy | 1 | BeFree |
umls:C0521707 | Bilateral cataracts (disorder) | 1 | BeFree |
umls:C0525045 | Mood Disorders | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
umls:C0750952 | Biliary Tract Cancer | 1 | BeFree |
umls:C0751651 | Mitochondrial Diseases | 1 | BeFree |
umls:C0917796 | Optic Atrophy, Hereditary, Leber | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |