 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for OR51E1 |
 Gene summary |
| Basic gene information | Gene symbol | OR51E1 |
| Gene name | olfactory receptor, family 51, subfamily E, member 1 | |
| Synonyms | D-GPCR|DGPCR|GPR136|GPR164|OR51E1P|OR52A3P|POGR|PSGR2 | |
| Cytomap | UCSC genome browser: 11p15.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152430.3, | |
| Description | Dresden-G-protein-coupled receptorG-protein coupled receptor 164olfactory receptor 51E1olfactory receptor 52A3olfactory receptor OR11-15olfactory receptor, family 51, subfamily E, member 1 pseudogeneolfactory receptor, family 52, subfamily A, member | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611267 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000180785 | ||
| HPRD : 14996 | ||
| Vega : OTTHUMG00000157024 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OR51E1 | |
| BioGPS: 143503 | ||
| Pathway | NCI Pathway Interaction Database: OR51E1 | |
| KEGG: OR51E1 | ||
| REACTOME: OR51E1 | ||
| Pathway Commons: OR51E1 | ||
| Context | iHOP: OR51E1 | |
| ligand binding site mutation search in PubMed: OR51E1 | ||
| UCL Cancer Institute: OR51E1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of OR51E1 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for OR51E1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -2.158430003 | -4.629804141 | 2.471374138 | 5.39E-14 | 4.89E-13 |
| LIHC | -1.846740072 | -4.531888072 | 2.685148 | 4.67E-22 | 4.15E-20 |
| KIRC | 1.357081539 | -1.203546238 | 2.560627778 | 2.53E-22 | 2.36E-21 |
| LUSC | -2.33896266 | -4.741641091 | 2.402678431 | 1.50E-18 | 1.46E-17 |
| PRAD | 4.429831005 | 2.708279082 | 1.721551923 | 0.00077 | 0.002560193 |
| HNSC | -2.006813002 | -3.144206025 | 1.137393023 | 7.27E-05 | 0.000338665 |
| Top |
| TissGene-miRNA for OR51E1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for OR51E1 |
| TissGeneSNV for OR51E1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R302* | SKCM | 3 |
| p.R270C | COAD | 2 |
| p.P5S | SKCM | 2 |
| p.P21S | SKCM | 1 |
| p.S11N | COAD | 1 |
| p.V276I | UCEC | 1 |
| p.R196Q | DLBC | 1 |
| p.V244I | KIRP | 1 |
| p.R53W | BLCA | 1 |
| p.M62V | SKCM | 1 |
| p.G7S | KIRC | 1 |
| p.R125H | SARC | 1 |
| p.R304C | STAD | 1 |
| p.G44R | STAD | 1 |
| p.S66* | LUAD | 1 |
| p.R307Q | UCEC | 1 |
| p.T140K | LUAD | 1 |
| p.L225I | UCEC | 1 |
| p.Q96* | SKCM | 1 |
| p.S316A | KIRC | 1 |
| p.R304H | UCEC | 1 |
| p.I301N | BLCA | 1 |
| p.R154W | GBM | 1 |
| p.P33T | UCEC | 1 |
| p.K83N | SKCM | 1 |
| p.V276I | BLCA | 1 |
| p.P56L | MESO | 1 |
| p.Y254N | LIHC | 1 |
| p.G202S | SKCM | 1 |
| p.P33S | SKCM | 1 |
| p.D193Y | LUAD | 1 |
| p.R143H | STAD | 1 |
| p.V244I | LGG | 1 |
| p.R265H | LUAD | 1 |
| p.G259* | UCEC | 1 |
| p.R125H | STAD | 1 |
| p.R134L | TGCT | 1 |
| p.E25D | LUAD | 1 |
| p.C60F | LUAD | 1 |
| p.S77T | SKCM | 1 |
| p.R143C | SKCM | 1 |
| p.P163S | SKCM | 1 |
| p.H108Y | SKCM | 1 |
| p.S218F | SKCM | 1 |
| p.P33Q | SKCM | 1 |
| p.R302X | SKCM | 1 |
| p.I176T | LUAD | 1 |
| p.D4N | SKCM | 1 |
| p.R269W | BRCA | 1 |
| p.I166M | LUAD | 1 |
| p.A315T | STAD | 1 |
| p.G71R | GBM | 1 |
| p.V138I | UCEC | 1 |
| p.R270C | CESC | 1 |
| p.A12D | SARC | 1 |
| p.L118M | PAAD | 1 |
| p.E9K | SKCM | 1 |
| p.D193N | SKCM | 1 |
| p.Q103H | LGG | 1 |
| p.T313A | STAD | 1 |
| p.G295R | SKCM | 1 |
| p.P161S | LIHC | 1 |
| p.I224F | PAAD | 1 |
| p.Q68* | SKCM | 1 |
| p.I129M | LUSC | 1 |
| p.V255L | ACC | 1 |
| p.M84I | COAD | 1 |
| p.P21L | SKCM | 1 |
| p.S66L | BLCA | 1 |
| p.L177F | SKCM | 1 |
| p.R154W | COAD | 1 |
| p.H246R | ESCA | 1 |
| Top |
| TissGeneCNV for OR51E1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for OR51E1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for OR51E1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for OR51E1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for OR51E1 |
| TissGeneDrug for OR51E1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for OR51E1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
| umls:C0600139 | Prostate carcinoma | 4 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0206695 | Carcinoma, Neuroendocrine | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | CTD_human |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |