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| TissGeneSummary for DNHD1 |
 Gene summary |
| Basic gene information | Gene symbol | DNHD1 |
| Gene name | dynein heavy chain domain 1 | |
| Synonyms | C11orf47|CCDC35|DHCD1|DNHD1L | |
| Cytomap | UCSC genome browser: 11p15.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_144666.2, NM_173589.3, | |
| Description | DNHD1 variant proteincoiled-coil domain containing 35dynein heavy chain domain 1-like proteindynein heavy chain domain-containing protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000179532 | ||
| HPRD : 08137 | ||
| Vega : OTTHUMG00000133403 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DNHD1 | |
| BioGPS: 144132 | ||
| Pathway | NCI Pathway Interaction Database: DNHD1 | |
| KEGG: DNHD1 | ||
| REACTOME: DNHD1 | ||
| Pathway Commons: DNHD1 | ||
| Context | iHOP: DNHD1 | |
| ligand binding site mutation search in PubMed: DNHD1 | ||
| UCL Cancer Institute: DNHD1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUCEC,UCS | |
| Reference showing the relevant tissue of DNHD1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DNHD1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.223451862 | -0.186939581 | -1.036512281 | 1.77E-18 | 1.13E-17 |
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| TissGene-miRNA for DNHD1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DNHD1 |
| TissGeneSNV for DNHD1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N694S | PRAD | 2 |
| p.Q697R | PRAD | 2 |
| p.N694S | LGG | 2 |
| p.H2861N | COAD | 2 |
| p.Q697R | LGG | 2 |
| p.R3916C | UCEC | 1 |
| p.Q4671R | UCEC | 1 |
| p.W348G | UCEC | 1 |
| p.R449W | STAD | 1 |
| p.K2071N | UCEC | 1 |
| p.V2820I | UCEC | 1 |
| p.D4329N | SKCM | 1 |
| p.L140F | KIRC | 1 |
| p.D18H | BLCA | 1 |
| p.V210M | LUAD | 1 |
| p.D1501N | UCEC | 1 |
| p.G2079R | UCEC | 1 |
| p.E3989K | SKCM | 1 |
| p.L3029F | THYM | 1 |
| p.S1226P | ESCA | 1 |
| p.R3459C | READ | 1 |
| p.K4719* | PRAD | 1 |
| p.Q251P | PAAD | 1 |
| p.Q477X | STAD | 1 |
| p.R4478W | UCEC | 1 |
| p.K1486E | LIHC | 1 |
| p.S2248G | SARC | 1 |
| p.R4462H | BRCA | 1 |
| p.L2889P | UCEC | 1 |
| p.A4700V | STAD | 1 |
| p.R3575Q | UCEC | 1 |
| p.S4556L | UCEC | 1 |
| p.S2965I | UCEC | 1 |
| p.D3018N | BRCA | 1 |
| p.P3714S | SARC | 1 |
| p.P4589L | UCEC | 1 |
| p.R82H | LGG | 1 |
| p.R3851* | STAD | 1 |
| p.R3817Q | COAD | 1 |
| p.R95C | SKCM | 1 |
| p.M4314R | HNSC | 1 |
| p.Y4115* | GBM | 1 |
| p.I4666T | DLBC | 1 |
| p.N694S | SKCM | 1 |
| p.R195H | BLCA | 1 |
| p.P116H | HNSC | 1 |
| p.V853L | ACC | 1 |
| p.Q1898R | UCEC | 1 |
| p.H2443Y | BRCA | 1 |
| p.A209V | STAD | 1 |
| p.Y4323X | LIHC | 1 |
| p.P362L | SKCM | 1 |
| p.G2043E | CESC | 1 |
| p.Y3770C | PAAD | 1 |
| p.G4483D | SKCM | 1 |
| p.T189A | UCEC | 1 |
| p.H1249N | LIHC | 1 |
| p.A4541V | UCEC | 1 |
| p.A4312G | STAD | 1 |
| p.E3145K | SARC | 1 |
| p.S4421L | BLCA | 1 |
| p.Q1019H | SARC | 1 |
| p.S3950T | LIHC | 1 |
| p.R463* | SKCM | 1 |
| p.S588F | PRAD | 1 |
| p.S3095L | CESC | 1 |
| p.F326V | BLCA | 1 |
| p.P2967L | LIHC | 1 |
| p.S4011I | UCEC | 1 |
| p.L4207H | KIRP | 1 |
| p.R304W | LUAD | 1 |
| p.R1168C | BRCA | 1 |
| p.D565N | BLCA | 1 |
| p.V1072M | COAD | 1 |
| p.A4527T | COAD | 1 |
| p.Y526C | LGG | 1 |
| p.S3865C | LUAD | 1 |
| p.A512T | STAD | 1 |
| p.A4661V | PAAD | 1 |
| p.A2961T | ACC | 1 |
| p.D4701E | HNSC | 1 |
| p.L3942V | BLCA | 1 |
| p.S3445L | BRCA | 1 |
| p.F4586L | LIHC | 1 |
| p.A2651V | ESCA | 1 |
| p.Q697R | SKCM | 1 |
| p.R1901C | CESC | 1 |
| p.E1232X | ESCA | 1 |
| p.A1393V | ACC | 1 |
| p.R4048Q | SKCM | 1 |
| p.R1026Q | UCEC | 1 |
| p.L2943M | KIRP | 1 |
| p.A1354V | UCEC | 1 |
| p.G489C | STAD | 1 |
| p.R95H | COAD | 1 |
| p.R1148Q | READ | 1 |
| p.G330R | OV | 1 |
| p.Q4463E | LUAD | 1 |
| p.R1300C | BRCA | 1 |
| p.E504Q | HNSC | 1 |
| p.I361S | MESO | 1 |
| p.T3346M | ESCA | 1 |
| p.E4378Q | BLCA | 1 |
| p.W1162C | LIHC | 1 |
| p.G4512S | BLCA | 1 |
| p.P35L | SKCM | 1 |
| p.G198S | HNSC | 1 |
| p.C3394Y | COAD | 1 |
| p.R429W | SKCM | 1 |
| p.R463* | BLCA | 1 |
| p.R3809C | UCEC | 1 |
| p.S4428T | PRAD | 1 |
| p.R370H | UCEC | 1 |
| p.E504Q | BLCA | 1 |
| p.Q3842H | BLCA | 1 |
| p.L786M | UCEC | 1 |
| p.S3245N | COAD | 1 |
| p.L4209R | SKCM | 1 |
| p.L462F | READ | 1 |
| p.H566Y | SKCM | 1 |
| p.E1232K | COAD | 1 |
| p.C1399W | UCEC | 1 |
| p.A4570V | STAD | 1 |
| p.R4462C | BLCA | 1 |
| p.S419Y | BLCA | 1 |
| p.R3797Q | LGG | 1 |
| p.K260R | ESCA | 1 |
| p.T745M | COAD | 1 |
| p.S4694N | PAAD | 1 |
| p.D3048Y | COAD | 1 |
| p.R1156Q | DLBC | 1 |
| p.V3931E | KIRP | 1 |
| p.R3459H | UCEC | 1 |
| p.S2199N | COAD | 1 |
| p.R4407Q | COAD | 1 |
| p.S2610F | ESCA | 1 |
| p.R4045S | LUAD | 1 |
| p.Q477* | STAD | 1 |
| p.C2908F | SARC | 1 |
| p.E4488K | LUAD | 1 |
| p.E3635Q | CESC | 1 |
| p.S4706T | HNSC | 1 |
| p.R3247Q | UCEC | 1 |
| p.Q4086* | LUAD | 1 |
| p.R2222H | COAD | 1 |
| p.E208K | SKCM | 1 |
| p.F4079Y | SKCM | 1 |
| p.D3557A | COAD | 1 |
| p.P257S | THYM | 1 |
| p.R1863H | ESCA | 1 |
| p.L1744M | LIHC | 1 |
| p.V240E | COAD | 1 |
| p.I3819T | ESCA | 1 |
| p.P2706T | COAD | 1 |
| p.R2191X | READ | 1 |
| p.S266I | UCEC | 1 |
| p.S1335L | CESC | 1 |
| p.Q251E | LUAD | 1 |
| p.R3830H | COAD | 1 |
| p.P4093S | SKCM | 1 |
| p.K3743N | LUAD | 1 |
| p.E241V | STAD | 1 |
| p.D4571G | STAD | 1 |
| p.G4692A | STAD | 1 |
| p.Q1716H | MESO | 1 |
| p.S3518L | COAD | 1 |
| p.R1020H | COAD | 1 |
| p.S3877R | THCA | 1 |
| p.R4066W | LUAD | 1 |
| p.F1789L | READ | 1 |
| p.T4645M | COAD | 1 |
| p.T1684A | LIHC | 1 |
| p.R4557H | COAD | 1 |
| p.V975I | KICH | 1 |
| p.L4264V | BLCA | 1 |
| p.P4612H | STAD | 1 |
| p.E1030K | UCEC | 1 |
| p.G4544D | HNSC | 1 |
| p.R370C | READ | 1 |
| p.R4532C | UCEC | 1 |
| p.R4478Q | PRAD | 1 |
| p.Q171H | LUSC | 1 |
| p.R4591L | COAD | 1 |
| p.E4033K | LUAD | 1 |
| p.S270L | HNSC | 1 |
| p.R2265L | TGCT | 1 |
| p.D4204Y | COAD | 1 |
| p.I3897M | HNSC | 1 |
| p.A2182V | UCEC | 1 |
| p.R387Q | COAD | 1 |
| p.P2946S | UCEC | 1 |
| p.P2755S | DLBC | 1 |
| p.K3498N | UCEC | 1 |
| p.R463X | SKCM | 1 |
| p.R1772* | UCEC | 1 |
| p.M735I | ACC | 1 |
| p.S4428C | HNSC | 1 |
| p.L4528V | OV | 1 |
| p.R4066W | PRAD | 1 |
| p.V572A | PAAD | 1 |
| p.C4051R | STAD | 1 |
| p.G1610R | KIRC | 1 |
| p.R3895H | LGG | 1 |
| p.R1772Q | DLBC | 1 |
| p.P2755S | COAD | 1 |
| p.G1987D | UCEC | 1 |
| p.Q4454* | BLCA | 1 |
| p.K1446M | UCEC | 1 |
| p.R552K | LUAD | 1 |
| p.S2748G | LIHC | 1 |
| p.T4200S | HNSC | 1 |
| p.L1661P | UCEC | 1 |
| p.R2265Q | COAD | 1 |
| p.S3966R | HNSC | 1 |
| p.D1641N | UCEC | 1 |
| p.V2374M | ACC | 1 |
| p.F107C | HNSC | 1 |
| p.R4579H | STAD | 1 |
| p.R861H | COAD | 1 |
| p.L4327V | UCEC | 1 |
| p.G3935C | ESCA | 1 |
| p.Q119* | SKCM | 1 |
| p.F329V | SKCM | 1 |
| p.T4498M | SKCM | 1 |
| p.V744E | LIHC | 1 |
| p.G4065S | SKCM | 1 |
| p.E3607K | MESO | 1 |
| p.S3905I | LUAD | 1 |
| p.G4483S | SKCM | 1 |
| p.P321L | SKCM | 1 |
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| TissGeneCNV for DNHD1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DNHD1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ330913 | DNHD1-TCP11L1 | chr11:6569134 | chr11:33083114 |
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| TissGeneNet for DNHD1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| COAD (tumor) | COAD (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| KICH (tumor) | KICH (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| STAD (tumor) | STAD (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| THCA (tumor) | THCA (normal) |
| DNHD1, UBC, PLK1 (tumor) | DNHD1, UBC, PLK1 (normal) |
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| TissGeneProg for DNHD1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DNHD1 |
| TissGeneDrug for DNHD1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DNHD1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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