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| TissGeneSummary for SLC2A14 |
 Gene summary |
| Basic gene information | Gene symbol | SLC2A14 |
| Gene name | solute carrier family 2 (facilitated glucose transporter), member 14 | |
| Synonyms | GLUT14|SLC2A3P3 | |
| Cytomap | UCSC genome browser: 12p13.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001286233.1, NM_001286234.1,NM_001286235.1,NM_001286236.1,NM_001286237.1, NM_153449.3, | |
| Description | glucose transporter type 14solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 3solute carrier family 2, facilitated glucose transporter member 14 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611039 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000173262 | ||
| HPRD : 11573 | ||
| Vega : OTTHUMG00000168463 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC2A14 | |
| BioGPS: 144195 | ||
| Pathway | NCI Pathway Interaction Database: SLC2A14 | |
| KEGG: SLC2A14 | ||
| REACTOME: SLC2A14 | ||
| Pathway Commons: SLC2A14 | ||
| Context | iHOP: SLC2A14 | |
| ligand binding site mutation search in PubMed: SLC2A14 | ||
| UCL Cancer Institute: SLC2A14 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SLC2A14 | The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein. Amir Shaghaghi M, Murphy B, Eck P. Biochem Cell Biol. 2016 Aug;94(4):331-5. doi: 10.1139/bcb-2015-0089. Epub 2016 Apr 25 (pmid:27460888) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC2A14 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -0.259679079 | 0.742564025 | -1.002243103 | 1.66E-06 | 5.40E-06 |
| KIRC | 0.397587684 | -1.541383149 | 1.938970833 | 4.46E-19 | 3.20E-18 |
| BLCA | -1.348242872 | 0.231025549 | -1.579268421 | 0.000572 | 0.004543314 |
| Top |
| TissGene-miRNA for SLC2A14 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-92a-3p | MIMAT0000092 | 0.048 | -0.26 | 60 |
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| TissGeneMut for SLC2A14 |
| TissGeneSNV for SLC2A14 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G364R | SKCM | 2 |
| p.L107P | OV | 1 |
| p.R248P | LUAD | 1 |
| p.T60K | COAD | 1 |
| p.H382Y | SKCM | 1 |
| p.A335V | HNSC | 1 |
| p.R115L | HNSC | 1 |
| p.T39A | PAAD | 1 |
| p.G506E | BRCA | 1 |
| p.E276K | SKCM | 1 |
| p.F46V | UCEC | 1 |
| p.G441R | UCEC | 1 |
| p.G106R | UCEC | 1 |
| p.I81N | KIRP | 1 |
| p.S117X | STAD | 1 |
| p.V504I | COAD | 1 |
| p.S446Y | THYM | 1 |
| p.A126V | PRAD | 1 |
| p.R240K | SKCM | 1 |
| p.V474I | KIRC | 1 |
| p.G152A | UCEC | 1 |
| p.F471L | BLCA | 1 |
| p.S90Y | UCEC | 1 |
| p.R234K | SKCM | 1 |
| p.G364V | STAD | 1 |
| p.G456R | UCEC | 1 |
| p.E199* | LIHC | 1 |
| p.M505I | SKCM | 1 |
| p.R267Q | GBM | 1 |
| p.I66N | KIRP | 1 |
| p.L217F | SKCM | 1 |
| p.Q47* | SKCM | 1 |
| p.V287A | UCEC | 1 |
| p.G156R | SKCM | 1 |
| p.I135F | KIRP | 1 |
| p.R252W | HNSC | 1 |
| p.A335T | HNSC | 1 |
| p.R148H | THYM | 1 |
| p.L467F | LUAD | 1 |
| p.T247M | ESCA | 1 |
| p.W223C | LUSC | 1 |
| p.S509N | SKCM | 1 |
| p.P423L | SKCM | 1 |
| p.G506E | COAD | 1 |
| p.G503S | UCEC | 1 |
| p.T42A | UCEC | 1 |
| p.R111C | STAD | 1 |
| p.P423S | SKCM | 1 |
| p.E415K | SKCM | 1 |
| p.R115H | COAD | 1 |
| p.E483D | KIRC | 1 |
| p.V30F | SKCM | 1 |
| p.A414S | GBM | 1 |
| p.E515K | SKCM | 1 |
| p.V96I | THCA | 1 |
| p.S223C | ESCA | 1 |
| p.I333F | LUAD | 1 |
| p.G106R | COAD | 1 |
| p.D268N | SKCM | 1 |
| p.S376Y | STAD | 1 |
| p.S79Y | LUAD | 1 |
| p.G121R | UCEC | 1 |
| p.G176S | COAD | 1 |
| p.S117* | STAD | 1 |
| p.T247M | COAD | 1 |
| p.W434* | SKCM | 1 |
| p.N85H | UCEC | 1 |
| p.D484N | SKCM | 1 |
| p.D484Y | BLCA | 1 |
| p.V105I | BLCA | 1 |
| p.R478C | LIHC | 1 |
| p.G515W | UCEC | 1 |
| p.Q194K | LUAD | 1 |
| p.R306* | GBM | 1 |
| p.L442V | DLBC | 1 |
| p.T247M | BRCA | 1 |
| p.G167A | UCEC | 1 |
| p.K63Q | UCEC | 1 |
| p.I220V | LUAD | 1 |
| p.I169M | HNSC | 1 |
| p.V192G | UCS | 1 |
| p.Y165H | PAAD | 1 |
| p.G106R | STAD | 1 |
| p.E206G | HNSC | 1 |
| p.R115H | LGG | 1 |
| p.I120F | KIRP | 1 |
| p.R478C | LGG | 1 |
| p.A33T | LGG | 1 |
| p.S223N | SKCM | 1 |
| p.F61V | UCEC | 1 |
| Top |
| TissGeneCNV for SLC2A14 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC2A14 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | GBM | TCGA-06-0238-01A | FOXM1-SLC2A14 | In-frame | Chr12:2977729 | Chr12:7970630 |
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| TissGeneNet for SLC2A14 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC2A14 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC2A14 |
| TissGeneDrug for SLC2A14 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC2A14 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002395 | Alzheimer's Disease | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0020179 | Huntington Disease | 2 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 2 | BeFree |
| umls:C0085207 | Gestational Diabetes | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0004997 | Benign Ovarian Neoplasm | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007107 | Malignant neoplasm of larynx | 1 | BeFree |
| umls:C0007125 | Carcinoma, Ehrlich Tumor | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0008497 | Choriocarcinoma | 1 | BeFree |
| umls:C0014548 | Epilepsy, Generalized | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0020456 | Hyperglycemia | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0025312 | Meningomyelocele | 1 | BeFree |
| umls:C0027533 | Neck Neoplasms | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0205851 | Germ cell tumor | 1 | BeFree |
| umls:C0206704 | Carcinoma, Large Cell | 1 | BeFree |
| umls:C0242363 | Islet Cell Tumor | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
| umls:C0524528 | Pervasive Development Disorder | 1 | BeFree |
| umls:C0595921 | Intraocular pressure disorder | 1 | BeFree |
| umls:C0595989 | Carcinoma of larynx | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
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