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| TissGeneSummary for SERPINA12 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA12 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | |
| Synonyms | OL-64 | |
| Cytomap | UCSC genome browser: 14q32.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173850.2, | |
| Description | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12serpin A12vaspinvisceral adipose tissue-derived serine protease inhibitorvisceral adipose-specific SERPIN | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000165953 | ||
| HPRD : 18038 | ||
| Vega : OTTHUMG00000171349 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA12 | |
| BioGPS: 145264 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA12 | |
| KEGG: SERPINA12 | ||
| REACTOME: SERPINA12 | ||
| Pathway Commons: SERPINA12 | ||
| Context | iHOP: SERPINA12 | |
| ligand binding site mutation search in PubMed: SERPINA12 | ||
| UCL Cancer Institute: SERPINA12 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of SERPINA12 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SERPINA12 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for SERPINA12 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA12 |
| TissGeneSNV for SERPINA12 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R211G | BLCA | 2 |
| p.L204V | BLCA | 1 |
| p.S93N | LAML | 1 |
| p.Y118H | LUAD | 1 |
| p.N267H | UCEC | 1 |
| p.R345C | UCEC | 1 |
| p.F180C | KIRP | 1 |
| p.A173T | UCEC | 1 |
| p.E35K | UCEC | 1 |
| p.V201A | BRCA | 1 |
| p.A356T | GBM | 1 |
| p.M378I | LUSC | 1 |
| p.F139L | LUSC | 1 |
| p.A342T | READ | 1 |
| p.E225K | HNSC | 1 |
| p.Q142H | LUAD | 1 |
| p.L5V | LUAD | 1 |
| p.F209L | COAD | 1 |
| p.L260M | ESCA | 1 |
| p.Q125H | KIRC | 1 |
| p.K155N | UCEC | 1 |
| p.D290G | PAAD | 1 |
| p.G135E | BLCA | 1 |
| p.W39R | UCEC | 1 |
| p.L15F | SKCM | 1 |
| p.R148P | HNSC | 1 |
| p.G245D | SKCM | 1 |
| p.K279N | LUAD | 1 |
| p.K58T | STAD | 1 |
| p.I120F | ESCA | 1 |
| p.A64V | ESCA | 1 |
| p.A342T | COAD | 1 |
| p.E397Q | LUAD | 1 |
| p.Q100L | KIRC | 1 |
| p.R211* | SKCM | 1 |
| p.A45V | LGG | 1 |
| p.M107L | BLCA | 1 |
| p.E333Q | BLCA | 1 |
| p.R148H | LUAD | 1 |
| p.D253Y | LUAD | 1 |
| p.D227Y | COAD | 1 |
| p.V349L | ACC | 1 |
| p.R301H | UCEC | 1 |
| p.M240I | BRCA | 1 |
| p.S182R | LUAD | 1 |
| p.P263H | LUSC | 1 |
| p.W295* | SKCM | 1 |
| p.V402L | LUAD | 1 |
| p.G286E | SKCM | 1 |
| p.R148L | LUAD | 1 |
| p.K149T | STAD | 1 |
| p.P146L | LUAD | 1 |
| p.K18R | COAD | 1 |
| p.G245D | LUAD | 1 |
| p.N29Y | THCA | 1 |
| p.P23Q | HNSC | 1 |
| p.R243C | SKCM | 1 |
| p.R243C | UCEC | 1 |
| p.N67S | STAD | 1 |
| p.I271M | BLCA | 1 |
| p.P76S | SKCM | 1 |
| p.E357Q | LUAD | 1 |
| p.V303L | KIRP | 1 |
| p.A8T | STAD | 1 |
| p.G413E | SKCM | 1 |
| p.D290N | UCEC | 1 |
| p.S235L | BLCA | 1 |
| p.K224E | BLCA | 1 |
| p.N2S | SKCM | 1 |
| p.I341M | LUAD | 1 |
| p.L274F | SKCM | 1 |
| p.E161K | COAD | 1 |
| p.S324Y | ESCA | 1 |
| p.Q174* | SKCM | 1 |
| p.F228L | UCEC | 1 |
| p.S93N | BLCA | 1 |
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| TissGeneCNV for SERPINA12 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA12 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49W-01A | DICER1-SERPINA12 | CDS-5'UTR | chr14:95590532 | chr14:94982491 |
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| TissGeneNet for SERPINA12 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SERPINA12 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SERPINA12 |
| TissGeneDrug for SERPINA12 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA12 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 8 | BeFree,GWASCAT,RGD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree,GAD,RGD |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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