TissGeneSummary for SLC47A2 |
Gene summary |
Basic gene information | Gene symbol | SLC47A2 |
Gene name | solute carrier family 47 (multidrug and toxin extrusion), member 2 | |
Synonyms | MATE2|MATE2-B|MATE2-K|MATE2K | |
Cytomap | UCSC genome browser: 17p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001099646.1, NM_001256663.1,NM_152908.3, | |
Description | H+/organic cation antiporterMATE-2hMATE-2kidney-specific H(+)/organic cation antiportermultidrug and toxin extrusion 2multidrug and toxin extrusion protein 2solute carrier family 47, member 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609833 | |
HGNC : HGNC | ||
Ensembl : ENSG00000180638 | ||
HPRD : 08710 | ||
Vega : OTTHUMG00000059464 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC47A2 | |
BioGPS: 146802 | ||
Pathway | NCI Pathway Interaction Database: SLC47A2 | |
KEGG: SLC47A2 | ||
REACTOME: SLC47A2 | ||
Pathway Commons: SLC47A2 | ||
Context | iHOP: SLC47A2 | |
ligand binding site mutation search in PubMed: SLC47A2 | ||
UCL Cancer Institute: SLC47A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC47A2 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC47A2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -3.017317971 | -1.241526743 | -1.775791228 | 2.17E-37 | 4.94E-36 |
KIRC | 0.166492117 | 4.537532394 | -4.371040278 | 1.29E-21 | 1.13E-20 |
KICH | -2.216068883 | 3.917043117 | -6.133112 | 7.42E-14 | 1.11E-12 |
KIRP | 2.704917117 | 5.304204617 | -2.5992875 | 0.000897 | 0.002504451 |
HNSC | 2.062797349 | 0.675678745 | 1.387118605 | 0.000465 | 0.001752513 |
LUSC | -0.351266217 | -2.002152491 | 1.650886275 | 5.17E-05 | 0.00011015 |
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TissGene-miRNA for SLC47A2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC47A2 |
TissGeneSNV for SLC47A2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A539T | COAD | 1 |
p.G407E | SKCM | 1 |
p.R141Q | STAD | 1 |
p.L269Q | ESCA | 1 |
p.A336V | SKCM | 1 |
p.G85X | STAD | 1 |
p.P24H | COAD | 1 |
p.G289R | KIRP | 1 |
p.I364R | CHOL | 1 |
p.L363P | LGG | 1 |
p.V369I | BRCA | 1 |
p.R555C | ACC | 1 |
p.E275D | LUAD | 1 |
p.V232A | UCEC | 1 |
p.S90L | BLCA | 1 |
p.F517I | COAD | 1 |
p.I423M | CESC | 1 |
p.D251N | SKCM | 1 |
p.I386R | CHOL | 1 |
p.S191* | CESC | 1 |
p.H210Y | SKCM | 1 |
p.F291L | KIRC | 1 |
p.L264I | LGG | 1 |
p.G81R | GBM | 1 |
p.G253R | KIRP | 1 |
p.T542M | UCEC | 1 |
p.A539T | THYM | 1 |
p.G85* | STAD | 1 |
p.S239Y | UCEC | 1 |
p.T542K | ESCA | 1 |
p.P199S | SKCM | 1 |
p.G452C | UCEC | 1 |
p.A561T | THYM | 1 |
p.G178V | SKCM | 1 |
p.E239D | LUAD | 1 |
p.R577C | ACC | 1 |
p.A561T | STAD | 1 |
p.S69L | PAAD | 1 |
p.C327S | LUAD | 1 |
p.G452S | STAD | 1 |
p.L233Q | ESCA | 1 |
p.A513S | LIHC | 1 |
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TissGeneCNV for SLC47A2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC47A2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-OL-A5RZ-01A | RASSF8-SLC47A2 | 5UTR-CDS | Chr12:26112081 | Chr17:19584983 |
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TissGeneNet for SLC47A2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC47A2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC47A2 |
TissGeneDrug for SLC47A2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC47A2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |