TissGeneSummary for ZNF578 |
Gene summary |
Basic gene information | Gene symbol | ZNF578 |
Gene name | zinc finger protein 578 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.41 | |
Type of gene | protein-coding | |
RefGenes | NM_152472.1, NM_001099694.1, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000258405 | ||
HPRD : 15857 | ||
Vega : OTTHUMG00000156468 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF578 | |
BioGPS: 147660 | ||
Pathway | NCI Pathway Interaction Database: ZNF578 | |
KEGG: ZNF578 | ||
REACTOME: ZNF578 | ||
Pathway Commons: ZNF578 | ||
Context | iHOP: ZNF578 | |
ligand binding site mutation search in PubMed: ZNF578 | ||
UCL Cancer Institute: ZNF578 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZNF578 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZNF578 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.521350052 | 0.107318575 | -1.628668627 | 1.23E-09 | 4.17E-09 |
KICH | -0.844200798 | 0.906019202 | -1.75022 | 5.38E-06 | 1.79E-05 |
KIRC | -0.211190575 | 1.047642758 | -1.258833333 | 1.64E-17 | 1.03E-16 |
BLCA | -1.542354903 | -0.106954903 | -1.4354 | 0.00118 | 0.008201 |
KIRP | -0.176019048 | 0.985315327 | -1.161334375 | 0.000301 | 0.000928256 |
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TissGene-miRNA for ZNF578 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZNF578 |
TissGeneSNV for ZNF578 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G311S | LUAD | 3 |
p.S301F | SKCM | 2 |
p.R559I | UCEC | 2 |
p.R272* | UCEC | 2 |
p.R23L | LUAD | 2 |
p.R362C | SKCM | 2 |
p.R272Q | SKCM | 2 |
p.H111Y | SKCM | 2 |
p.E51K | SKCM | 2 |
p.Q179* | SKCM | 1 |
p.Q410K | STAD | 1 |
p.L164F | CESC | 1 |
p.F212V | PRAD | 1 |
p.H334Y | BLCA | 1 |
p.G573S | SKCM | 1 |
p.A44V | READ | 1 |
p.V63M | LIHC | 1 |
p.S353C | BLCA | 1 |
p.P314L | ESCA | 1 |
p.E126K | SKCM | 1 |
p.H125N | BRCA | 1 |
p.E223K | LUSC | 1 |
p.S230Y | UCEC | 1 |
p.R559K | STAD | 1 |
p.R92T | LUAD | 1 |
p.H438Y | SKCM | 1 |
p.D186N | KIRC | 1 |
p.H421P | KIRP | 1 |
p.H333Y | LIHC | 1 |
p.S323T | BRCA | 1 |
p.L498P | LUAD | 1 |
p.N290S | COAD | 1 |
p.H473P | ESCA | 1 |
p.H578Y | DLBC | 1 |
p.H438N | LUAD | 1 |
p.L48S | LGG | 1 |
p.A555E | LUAD | 1 |
p.R502C | STAD | 1 |
p.A435V | SKCM | 1 |
p.K428N | LUAD | 1 |
p.M70W | HNSC | 1 |
p.R278C | SKCM | 1 |
p.Q118R | LIHC | 1 |
p.K490N | PAAD | 1 |
p.K372M | LUAD | 1 |
p.P286S | CESC | 1 |
p.Q250* | LUSC | 1 |
p.E94K | SKCM | 1 |
p.L330F | SKCM | 1 |
p.E291K | CESC | 1 |
p.H86Y | SKCM | 1 |
p.N211I | ESCA | 1 |
p.S76P | STAD | 1 |
p.E228Q | CESC | 1 |
p.L19V | LUSC | 1 |
p.D120Y | UCEC | 1 |
p.T331R | BLCA | 1 |
p.K266Q | COAD | 1 |
p.M70R | HNSC | 1 |
p.P20R | LUAD | 1 |
p.E452D | COAD | 1 |
p.I152S | PAAD | 1 |
p.Y208F | BRCA | 1 |
p.H168Q | LUAD | 1 |
p.I584V | COAD | 1 |
p.G311S | BLCA | 1 |
p.H333N | LUAD | 1 |
p.R502C | SKCM | 1 |
p.P482H | COAD | 1 |
p.W38C | LGG | 1 |
p.L330F | COAD | 1 |
p.E452D | LIHC | 1 |
p.E134Q | HNSC | 1 |
p.G237V | GBM | 1 |
p.S415L | DLBC | 1 |
p.E403D | BRCA | 1 |
p.F520L | STAD | 1 |
p.S527L | BLCA | 1 |
p.C460G | HNSC | 1 |
p.S497Y | UCEC | 1 |
p.E83K | SKCM | 1 |
p.D28N | SKCM | 1 |
p.Q21R | ESCA | 1 |
p.H333D | THCA | 1 |
p.S384* | BLCA | 1 |
p.G209E | SKCM | 1 |
p.R278C | UCEC | 1 |
p.N556H | LUSC | 1 |
p.S468* | LUSC | 1 |
p.G12R | SKCM | 1 |
p.D143Y | LUAD | 1 |
p.S325N | LUSC | 1 |
p.L41M | UCEC | 1 |
p.S216L | SKCM | 1 |
p.S582L | SKCM | 1 |
p.K406M | COAD | 1 |
p.R447T | STAD | 1 |
p.M70L | HNSC | 1 |
p.R50M | UCEC | 1 |
p.L579F | BLCA | 1 |
p.R503K | UCEC | 1 |
p.T303S | LUAD | 1 |
p.S295C | LUAD | 1 |
p.K322Q | COAD | 1 |
p.P314S | SKCM | 1 |
p.H449Y | SKCM | 1 |
p.I110S | STAD | 1 |
p.R195I | UCEC | 1 |
p.K119E | CESC | 1 |
p.Y315C | LIHC | 1 |
p.E459V | SKCM | 1 |
p.P20S | SKCM | 1 |
p.S384L | SKCM | 1 |
p.N206T | LIHC | 1 |
p.K260Q | COAD | 1 |
p.E32Q | LUSC | 1 |
p.S76L | LUAD | 1 |
p.S76* | LUAD | 1 |
p.R272X | ESCA | 1 |
p.E424D | UCEC | 1 |
p.R272* | ESCA | 1 |
p.S95I | LUAD | 1 |
p.R306H | STAD | 1 |
p.S468L | SARC | 1 |
p.H111Q | LUAD | 1 |
p.I263L | LIHC | 1 |
p.K518N | STAD | 1 |
p.D143N | SKCM | 1 |
p.S454P | STAD | 1 |
p.E107K | BLCA | 1 |
p.G137C | LUAD | 1 |
p.H449N | LIHC | 1 |
p.E459X | COAD | 1 |
p.E181* | LUAD | 1 |
p.M226I | CESC | 1 |
p.D154Y | CESC | 1 |
p.H333Y | SKCM | 1 |
p.T385A | COAD | 1 |
p.Q250* | CESC | 1 |
p.S589P | UCEC | 1 |
p.K512T | COAD | 1 |
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TissGeneCNV for ZNF578 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZNF578 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | R47413 | WDFY3-ZNF578 | chr4:85634225 | chr19:52994298 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IC-A6RF-01A | ZNF578-PIGX | Out-of-Frame | chr19:53008034 | chr3:196454793 |
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TissGeneNet for ZNF578 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZNF578 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZNF578 |
TissGeneDrug for ZNF578 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZNF578 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |