TissGeneSummary for IGFL2 |
Gene summary |
Basic gene information | Gene symbol | IGFL2 |
Gene name | IGF-like family member 2 | |
Synonyms | UNQ645|VPRI645 | |
Cytomap | UCSC genome browser: 19q13.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001002915.2, NM_001135113.1, | |
Description | insulin growth factor-like family member 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610545 | |
HGNC : HGNC | ||
Ensembl : ENSG00000204866 | ||
HPRD : 13729 | ||
Vega : OTTHUMG00000182492 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IGFL2 | |
BioGPS: 147920 | ||
Pathway | NCI Pathway Interaction Database: IGFL2 | |
KEGG: IGFL2 | ||
REACTOME: IGFL2 | ||
Pathway Commons: IGFL2 | ||
Context | iHOP: IGFL2 | |
ligand binding site mutation search in PubMed: IGFL2 | ||
UCL Cancer Institute: IGFL2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of IGFL2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IGFL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.455730254 | -3.330347712 | 3.786077966 | 9.92E-13 | 8.79E-12 |
LUAD | -0.411168869 | -3.558394731 | 3.147225862 | 4.08E-14 | 3.74E-13 |
BLCA | 0.271205723 | -4.028120593 | 4.299326316 | 4.24E-08 | 2.86E-06 |
BRCA | -0.921978488 | -3.455705681 | 2.533727193 | 1.87E-25 | 1.92E-24 |
LUSC | 0.122240191 | -2.964306868 | 3.086547059 | 2.76E-11 | 1.10E-10 |
HNSC | 1.77489336 | -1.066471756 | 2.841365116 | 1.49E-06 | 1.07E-05 |
COAD | -1.027178285 | -3.034151362 | 2.006973077 | 0.000299 | 0.000974865 |
STAD | -1.984914343 | -3.755511218 | 1.770596875 | 5.49E-05 | 0.00046769 |
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TissGene-miRNA for IGFL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IGFL2 |
TissGeneSNV for IGFL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S112F | SKCM | 2 |
p.A56T | STAD | 1 |
p.L81V | LGG | 1 |
p.D89N | COAD | 1 |
p.P58A | SKCM | 1 |
p.C77R | UCEC | 1 |
p.Q108H | LUAD | 1 |
p.L81I | STAD | 1 |
p.N57S | SKCM | 1 |
p.D93H | ESCA | 1 |
p.E60V | BRCA | 1 |
p.P130S | SKCM | 1 |
p.L92I | STAD | 1 |
p.S114G | SKCM | 1 |
p.N46S | SKCM | 1 |
p.P85L | SKCM | 1 |
p.P13H | LUAD | 1 |
p.D11N | LUAD | 1 |
p.P42L | SKCM | 1 |
p.F83C | SKCM | 1 |
p.A38S | LUAD | 1 |
p.A7V | SKCM | 1 |
p.A67T | LIHC | 1 |
p.D93N | LUAD | 1 |
p.P47A | SKCM | 1 |
p.L97F | LUAD | 1 |
p.L92V | LGG | 1 |
p.E124V | SKCM | 1 |
p.A27S | LUAD | 1 |
p.A67T | SKCM | 1 |
p.N99K | LUSC | 1 |
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TissGeneCNV for IGFL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IGFL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for IGFL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IGFL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IGFL2 |
TissGeneDrug for IGFL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IGFL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |