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| TissGeneSummary for ADRA1A |
 Gene summary |
| Basic gene information | Gene symbol | ADRA1A |
| Gene name | adrenoceptor alpha 1A | |
| Synonyms | ADRA1C|ADRA1L1|ALPHA1AAR | |
| Cytomap | UCSC genome browser: 8p21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000680.2, NM_033302.2,NM_033303.3,NM_033304.2, | |
| Description | G protein coupled receptoradrenergic, alpha-1A-, receptor variant 1adrenergic, alpha-1A-, receptor variant 11adrenergic, alpha-1A-, receptor variant 3adrenergic, alpha-1A-, receptor variant 5adrenergic, alpha-1A-, receptor variant 8alpha-1A adrenerg | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 104221 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120907 | ||
| HPRD : 00081 | ||
| Vega : OTTHUMG00000099459 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADRA1A | |
| BioGPS: 148 | ||
| Pathway | NCI Pathway Interaction Database: ADRA1A | |
| KEGG: ADRA1A | ||
| REACTOME: ADRA1A | ||
| Pathway Commons: ADRA1A | ||
| Context | iHOP: ADRA1A | |
| ligand binding site mutation search in PubMed: ADRA1A | ||
| UCL Cancer Institute: ADRA1A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of ADRA1A | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0043410 | positive regulation of MAPK cascade | 22120526 | GO:0043410 | positive regulation of MAPK cascade | 22120526 |
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| TissGeneExp for ADRA1A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -2.196726474 | 1.514328789 | -3.711055263 | 1.71E-46 | 8.57E-45 |
| LUAD | -2.239575203 | 1.328273072 | -3.567848276 | 3.50E-34 | 7.85E-32 |
| LUSC | -2.515276319 | 1.490513877 | -4.005790196 | 2.12E-27 | 6.45E-26 |
| STAD | -1.56300279 | 0.130631585 | -1.693634375 | 3.78E-06 | 5.03E-05 |
| KICH | -2.27836479 | -0.57208079 | -1.706284 | 1.25E-06 | 4.65E-06 |
| PRAD | 1.706762595 | 3.35939721 | -1.652634615 | 3.44E-08 | 3.69E-07 |
| COAD | -2.659695097 | -0.699360482 | -1.960334615 | 2.50E-10 | 3.20E-09 |
| HNSC | -2.794387673 | -1.276178371 | -1.518209302 | 5.05E-06 | 3.12E-05 |
| LIHC | 1.46788521 | 5.87544121 | -4.407556 | 2.77E-16 | 1.10E-14 |
| KIRP | -1.51208404 | -0.26540279 | -1.24668125 | 0.000918 | 0.002559896 |
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| TissGene-miRNA for ADRA1A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-377-3p | MIMAT0000730 | 0.034 | -0.31 | 56 |
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| TissGeneMut for ADRA1A |
| TissGeneSNV for ADRA1A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G425R | SKCM | 3 |
| p.T273M | STAD | 2 |
| p.I122M | BLCA | 2 |
| p.V367M | STAD | 2 |
| p.E320K | SKCM | 2 |
| p.R238Q | SKCM | 2 |
| p.V394I | STAD | 2 |
| p.S296F | SKCM | 1 |
| p.R436K | LUAD | 1 |
| p.R55X | READ | 1 |
| p.A251T | UCEC | 1 |
| p.G164S | UCEC | 1 |
| p.R423W | PAAD | 1 |
| p.P299H | HNSC | 1 |
| p.V379M | HNSC | 1 |
| p.V51I | LUAD | 1 |
| p.S24F | SKCM | 1 |
| p.G90C | UCEC | 1 |
| p.G425E | SKCM | 1 |
| p.M403I | UCEC | 1 |
| p.D225V | LUAD | 1 |
| p.G393S | SKCM | 1 |
| p.R376C | UCEC | 1 |
| p.V138I | STAD | 1 |
| p.V311I | BLCA | 1 |
| p.D444E | SARC | 1 |
| p.P20L | STAD | 1 |
| p.C326W | LIHC | 1 |
| p.A104V | THCA | 1 |
| p.H256Q | OV | 1 |
| p.V150I | COAD | 1 |
| p.C328Y | BLCA | 1 |
| p.T78M | COAD | 1 |
| p.C434F | ESCA | 1 |
| p.A84T | STAD | 1 |
| p.A189T | LGG | 1 |
| p.A408T | SKCM | 1 |
| p.D392N | SKCM | 1 |
| p.R423Q | HNSC | 1 |
| p.W397* | SKCM | 1 |
| p.R348G | STAD | 1 |
| p.M446I | BRCA | 1 |
| p.S188L | BLCA | 1 |
| p.V51I | UCEC | 1 |
| p.G244R | UCEC | 1 |
| p.T76S | KIRC | 1 |
| p.A169S | ESCA | 1 |
| p.A366V | SKCM | 1 |
| p.S121Y | LUSC | 1 |
| p.R133C | PAAD | 1 |
| p.E181K | SKCM | 1 |
| p.S348F | CESC | 1 |
| p.N462I | SKCM | 1 |
| p.K268N | STAD | 1 |
| p.L290F | PRAD | 1 |
| p.K268* | UCEC | 1 |
| p.Q431K | LUAD | 1 |
| p.S428R | ESCA | 1 |
| p.A84T | PAAD | 1 |
| p.W165C | HNSC | 1 |
| p.V47G | STAD | 1 |
| p.G393C | LUAD | 1 |
| p.S59L | STAD | 1 |
| p.S215N | SKCM | 1 |
| p.E437D | KIRP | 1 |
| p.A355V | SKCM | 1 |
| p.G315R | COAD | 1 |
| p.R260M | STAD | 1 |
| p.T451I | COAD | 1 |
| p.P293T | THYM | 1 |
| p.F312L | UCEC | 1 |
| p.S348Y | UCEC | 1 |
| p.E465D | ESCA | 1 |
| p.G35S | SKCM | 1 |
| p.A71T | STAD | 1 |
| p.W397X | SKCM | 1 |
| p.P131S | CESC | 1 |
| p.A169S | LUAD | 1 |
| p.R206H | BRCA | 1 |
| p.A189V | UCEC | 1 |
| p.K414E | LUSC | 1 |
| p.M374I | SKCM | 1 |
| p.C455Y | LGG | 1 |
| p.V232L | CESC | 1 |
| p.R387K | HNSC | 1 |
| p.R133C | UCEC | 1 |
| p.P131L | STAD | 1 |
| p.V277L | LUAD | 1 |
| p.P299L | SKCM | 1 |
| p.P447S | COAD | 1 |
| p.S428I | STAD | 1 |
| p.A408S | READ | 1 |
| p.A251T | ESCA | 1 |
| p.F385L | BLCA | 1 |
| p.K315T | ESCA | 1 |
| p.S215R | SARC | 1 |
| p.T391M | PAAD | 1 |
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| TissGeneCNV for ADRA1A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ADRA1A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ADRA1A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| COAD (tumor) | COAD (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| KICH (tumor) | KICH (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| STAD (tumor) | STAD (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| THCA (tumor) | THCA (normal) |
| ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (tumor) | ADRA1A, RGS2, PPP1R9B, ADRA1B, CXCR1, FLNC, NOS1, CXCR2, ADRA1D, BMP1, ABR (normal) |
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| TissGeneProg for ADRA1A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ADRA1A |
| TissGeneDrug for ADRA1A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00211 | Midodrine | Agonist | Small molecule | Approved |
| DB00298 | Dapiprazole | Antagonist | Small molecule | Approved |
| DB00370 | Mirtazapine | Binder | Small molecule | Approved |
| DB00388 | Phenylephrine | Small molecule | Approved | |
| DB00449 | Dipivefrin | Agonist | Small molecule | Approved |
| DB00457 | Prazosin | Antagonist | Small molecule | Approved |
| DB00575 | Clonidine | Agonist | Small molecule | Approved |
| DB00590 | Doxazosin | Antagonist | Small molecule | Approved |
| DB00679 | Thioridazine | Antagonist | Small molecule | Approved |
| DB00692 | Phentolamine | Antagonist | Small molecule | Approved |
| DB00699 | Nicergoline | Antagonist | Small molecule | Approved |
| DB00723 | Methoxamine | Agonist | Small molecule | Approved |
| DB00800 | Fenoldopam | Small molecule | Approved | |
| DB00831 | Trifluoperazine | Antagonist | Small molecule | Approved |
| DB00925 | Phenoxybenzamine | Antagonist | Small molecule | Approved |
| DB00935 | Oxymetazoline | Agonist | Small molecule | Approved |
| DB00964 | Apraclonidine | Agonist | Small molecule | Approved |
| DB01069 | Promethazine | Unknown | Small molecule | Approved |
| DB01162 | Terazosin | Antagonist | Small molecule | Approved |
| DB01253 | Ergonovine | Agonist | Small molecule | Approved |
| DB01295 | Bevantolol | Antagonist | Small molecule | Approved |
| DB01364 | Ephedrine | Small molecule | Approved | |
| DB01403 | Methotrimeprazine | Antagonist | Small molecule | Approved |
| DB01622 | Thioproperazine | Antagonist | Small molecule | Approved |
| DB04855 | Dronedarone | Antagonist | Small molecule | Approved |
| DB04946 | Iloperidone | Antagonist | Small molecule | Approved |
| DB06207 | Silodosin | Antagonist | Small molecule | Approved |
| DB06216 | Asenapine | Antagonist | Small molecule | Approved |
| DB06694 | Xylometazoline | Agonist | Small molecule | Approved |
| DB06706 | Isometheptene | Agonist | Small molecule | Approved |
| DB06711 | Naphazoline | Agonist | Small molecule | Approved |
| DB06764 | Tetryzoline | Agonist | Small molecule | Approved |
| DB00865 | Benzphetamine | Agonist | Small molecule | Approved|Illicit |
| DB01576 | Dextroamphetamine | Small molecule | Approved|Illicit | |
| DB01579 | Phendimetrazine | Agonist | Small molecule | Approved|Illicit |
| DB00346 | Alfuzosin | Antagonist | Small molecule | Approved|Investigational |
| DB00610 | Metaraminol | Agonist | Small molecule | Approved|Investigational |
| DB00656 | Trazodone | Antagonist | Small molecule | Approved|Investigational |
| DB00706 | Tamsulosin | Antagonist | Small molecule | Approved|Investigational |
| DB00751 | Epinastine | Unknown | Small molecule | Approved|Investigational |
| DB01136 | Carvedilol | Antagonist | Small molecule | Approved|Investigational |
| DB01200 | Bromocriptine | Agonist | Small molecule | Approved|Investigational |
| DB01624 | Zuclopenthixol | Antagonist | Small molecule | Approved|Investigational |
| DB00420 | Promazine | Antagonist | Small molecule | Approved|Vet_approved |
| DB00450 | Droperidol | Antagonist | Small molecule | Approved|Vet_approved |
| DB00797 | Tolazoline | Antagonist | Small molecule | Approved|Vet_approved |
| DB01614 | Acepromazine | Antagonist | Small molecule | Approved|Vet_approved |
| DB00397 | Phenylpropanolamine | Agonist | Small molecule | Approved|Vet_approved|Withdrawn |
| DB01186 | Pergolide | Agonist | Small molecule | Approved|Vet_approved|Withdrawn |
| DB01149 | Nefazodone | Antagonist | Small molecule | Approved|Withdrawn |
| DB06144 | Sertindole | Small molecule | Approved|Withdrawn |
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| TissGeneDisease for ADRA1A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020538 | Hypertensive disease | 15 | BeFree,GAD,LHGDN,RGD |
| umls:C1261473 | Sarcoma | 12 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 11 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 11 | BeFree |
| umls:C0678222 | Breast Carcinoma | 11 | BeFree |
| umls:C0596263 | Carcinogenesis | 10 | BeFree |
| umls:C0019693 | HIV Infections | 8 | BeFree |
| umls:C0036220 | Kaposi Sarcoma | 7 | BeFree |
| umls:C0036341 | Schizophrenia | 7 | BeFree,GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 7 | BeFree |
| umls:C0600139 | Prostate carcinoma | 7 | BeFree |
| umls:C0004096 | Asthma | 6 | BeFree |
| umls:C0018801 | Heart failure | 6 | BeFree |
| umls:C0018802 | Congestive heart failure | 6 | BeFree |
| umls:C0032002 | Pituitary Diseases | 6 | BeFree |
| umls:C0010417 | Cryptorchidism | 5 | BeFree |
| umls:C0025202 | melanoma | 5 | BeFree |
| umls:C0028754 | Obesity | 5 | BeFree,GAD |
| umls:C1263846 | Attention deficit hyperactivity disorder | 5 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 5 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree |
| umls:C0019340 | Herpes NOS | 4 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 4 | BeFree |
| umls:C0235290 | Taste bitter | 4 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 4 | BeFree |
| umls:C0003469 | Anxiety Disorders | 3 | BeFree |
| umls:C0036337 | Schizoaffective Disorder | 3 | BeFree,GAD |
| umls:C0162809 | Kallmann Syndrome | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C1292753 | Primary Effusion Lymphoma | 3 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 3 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human,RGD |
| umls:C0017636 | Glioblastoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree |
| umls:C0035335 | Retinoblastoma | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0220659 | Acrodysostosis | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0271623 | Hypogonadotropic hypogonadism | 2 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C0001314 | Acute Disease | 1 | GAD |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0005001 | Benign prostatic hypertrophy | 1 | GAD |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0005694 | Bladder neck obstruction | 1 | RGD |
| umls:C0006870 | Cannabis Dependence | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0010823 | Cytomegalovirus Infections | 1 | BeFree |
| umls:C0013146 | Drug abuse | 1 | BeFree |
| umls:C0013386 | Dyskinesia, Drug-Induced | 1 | GAD |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0016053 | Fibromyalgia | 1 | GAD |
| umls:C0020071 | Hereditary Sensory Autonomic Neuropathy, Type 1 | 1 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | RGD |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | GAD |
| umls:C0020649 | Hypotension | 1 | RGD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | LHGDN |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | CTD_human |
| umls:C0024031 | Low Back Pain | 1 | GAD |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0025261 | Memory Disorders | 1 | RGD |
| umls:C0025500 | Mesothelioma | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0027126 | Myotonic Dystrophy | 1 | BeFree |
| umls:C0030193 | Pain | 1 | GAD |
| umls:C0030201 | Pain, Postoperative | 1 | GAD |
| umls:C0030517 | Parathyroid Diseases | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | RGD |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0033774 | Pruritus | 1 | BeFree |
| umls:C0034931 | Reflex Sympathetic Dystrophy | 1 | GAD |
| umls:C0035334 | Retinitis Pigmentosa | 1 | BeFree |
| umls:C0036396 | Sciatica | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0040517 | Gilles de la Tourette syndrome | 1 | BeFree |
| umls:C0042024 | Urinary Incontinence | 1 | RGD |
| umls:C0042420 | Vasovagal syncope | 1 | BeFree |
| umls:C0078917 | Albinism, Ocular | 1 | BeFree |
| umls:C0085129 | Bronchial Hyperreactivity | 1 | GAD |
| umls:C0085580 | Essential Hypertension | 1 | BeFree |
| umls:C0149721 | Left Ventricular Hypertrophy | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | GAD |
| umls:C0152020 | Gastroparesis | 1 | GAD |
| umls:C0152136 | Low Tension Glaucoma | 1 | GAD |
| umls:C0162283 | Nephrogenic Diabetes Insipidus | 1 | BeFree |
| umls:C0220633 | Uveal melanoma | 1 | BeFree |
| umls:C0221765 | Chronic schizophrenia | 1 | BeFree |
| umls:C0234251 | Inflammatory pain | 1 | BeFree |
| umls:C0235480 | Paroxysmal atrial fibrillation | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | BeFree |
| umls:C0264657 | Renal sclerosis with hypertension | 1 | BeFree |
| umls:C0268318 | Cholestasis of pregnancy | 1 | BeFree |
| umls:C0339525 | Autosomal dominant retinitis pigmentosa | 1 | BeFree |
| umls:C0342345 | Hypoparathyroidism - autosomal dominant | 1 | BeFree |
| umls:C0392164 | Pulmonary Cystic Fibrosis | 1 | BeFree |
| umls:C0410226 | Congenital Myotonic Dystrophy | 1 | BeFree |
| umls:C0520947 | Clumsiness - motor delay | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0598428 | genetic hypertension | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0600519 | Ventricular Remodeling | 1 | CTD_human |
| umls:C0858600 | Taste sweet | 1 | BeFree |
| umls:C0936282 | Blastoma | 1 | BeFree |
| umls:C1141890 | Congenital long QT syndrome | 1 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 1 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1739363 | Prostatic Hypertrophy | 1 | BeFree |
| umls:C1836672 | Total Hypotrichosis, Mari type | 1 | BeFree |
| umls:C1864100 | PSEUDOHYPOPARATHYROIDISM, TYPE IB | 1 | BeFree |
| umls:C2937421 | Prostatic Hyperplasia | 1 | GAD,LHGDN |
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