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| TissGeneSummary for C1orf64 |
 Gene summary |
| Basic gene information | Gene symbol | C1orf64 |
| Gene name | chromosome 1 open reading frame 64 | |
| Synonyms | ERRF | |
| Cytomap | UCSC genome browser: 1p36.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_178840.3, | |
| Description | ER-related factoruncharacterized protein C1orf64 | |
| Modification date | 20141216 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 14492 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C1orf64 | |
| BioGPS: 149563 | ||
| Pathway | NCI Pathway Interaction Database: C1orf64 | |
| KEGG: C1orf64 | ||
| REACTOME: C1orf64 | ||
| Pathway Commons: C1orf64 | ||
| Context | iHOP: C1orf64 | |
| ligand binding site mutation search in PubMed: C1orf64 | ||
| UCL Cancer Institute: C1orf64 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastKidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCAKIRC,KIRP,KICH | |
| Reference showing the relevant tissue of C1orf64 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C1orf64 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.908100533 | 1.858252592 | -4.766353125 | 8.88E-24 | 8.66E-22 |
| THCA | -2.442940787 | 1.431991417 | -3.874932203 | 8.32E-29 | 4.61E-26 |
| PRAD | 2.768584083 | 0.68530716 | 2.083276923 | 5.36E-06 | 3.24E-05 |
| KIRC | -3.22889081 | 1.411686967 | -4.640577778 | 1.65E-53 | 2.64E-51 |
| HNSC | -2.839555765 | -1.557627858 | -1.281927907 | 0.00764 | 0.019556314 |
| LIHC | -1.518867533 | -2.986361533 | 1.467494 | 0.0015 | 0.003966071 |
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| TissGene-miRNA for C1orf64 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C1orf64 |
| TissGeneSNV for C1orf64 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P111L | BLCA | 1 |
| p.K53N | LUAD | 1 |
| p.W10C | LUAD | 1 |
| p.P126S | HNSC | 1 |
| p.E20Q | BLCA | 1 |
| p.M78I | SKCM | 1 |
| p.E87G | SKCM | 1 |
| p.V38I | COAD | 1 |
| p.E87K | SKCM | 1 |
| p.A104S | HNSC | 1 |
| p.G99S | SKCM | 1 |
| p.R107S | CESC | 1 |
| p.A66D | HNSC | 1 |
| p.A61T | UCEC | 1 |
| Top |
| TissGeneCNV for C1orf64 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C1orf64 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C1orf64 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C1orf64 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C1orf64 |
| TissGeneDrug for C1orf64 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C1orf64 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
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