TissGeneSummary for FAM71A |
Gene summary |
Basic gene information | Gene symbol | FAM71A |
Gene name | family with sequence similarity 71, member A | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q32.3 | |
Type of gene | protein-coding | |
RefGenes | NM_153606.3, | |
Description | protein FAM71A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162771 | ||
HPRD : 08735 | ||
Vega : OTTHUMG00000041084 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM71A | |
BioGPS: 149647 | ||
Pathway | NCI Pathway Interaction Database: FAM71A | |
KEGG: FAM71A | ||
REACTOME: FAM71A | ||
Pathway Commons: FAM71A | ||
Context | iHOP: FAM71A | |
ligand binding site mutation search in PubMed: FAM71A | ||
UCL Cancer Institute: FAM71A | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM71A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM71A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.513473465 | 0.177811018 | -1.691284483 | 1.28E-07 | 4.93E-07 |
LUSC | -1.513638915 | 0.425265007 | -1.938903922 | 8.15E-09 | 2.60E-08 |
HNSC | -1.691497282 | -0.347562399 | -1.343934884 | 1.26E-07 | 1.21E-06 |
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TissGene-miRNA for FAM71A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM71A |
TissGeneSNV for FAM71A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V59M | LUAD | 1 |
p.Q199* | BLCA | 1 |
p.G72A | LIHC | 1 |
p.S351F | BLCA | 1 |
p.G518D | SKCM | 1 |
p.R412Q | SKCM | 1 |
p.S17N | UCEC | 1 |
p.D488H | SKCM | 1 |
p.P188T | LUAD | 1 |
p.T70S | STAD | 1 |
p.R364Q | SKCM | 1 |
p.E47* | SKCM | 1 |
p.E96K | HNSC | 1 |
p.L157V | ESCA | 1 |
p.T378N | LIHC | 1 |
p.D49Y | BLCA | 1 |
p.G294S | UCEC | 1 |
p.D471N | BRCA | 1 |
p.P270T | LUAD | 1 |
p.R470K | SKCM | 1 |
p.G314V | LUAD | 1 |
p.E587D | HNSC | 1 |
p.R90Q | COAD | 1 |
p.M387I | UCEC | 1 |
p.E277Q | BLCA | 1 |
p.E179K | SKCM | 1 |
p.M18I | BLCA | 1 |
p.D61N | SKCM | 1 |
p.A104D | LUAD | 1 |
p.R440H | STAD | 1 |
p.R410M | KIRP | 1 |
p.S405N | COAD | 1 |
p.L224F | CESC | 1 |
p.S130Y | READ | 1 |
p.A468V | UCEC | 1 |
p.T272I | UCEC | 1 |
p.R175W | UVM | 1 |
p.S258F | SKCM | 1 |
p.A257V | LUAD | 1 |
p.G212E | SKCM | 1 |
p.R30* | LUAD | 1 |
p.R398W | CESC | 1 |
p.E277D | BRCA | 1 |
p.S519F | SKCM | 1 |
p.W513* | CESC | 1 |
p.R110C | COAD | 1 |
p.E168K | SKCM | 1 |
p.R140C | PAAD | 1 |
p.G26W | PRAD | 1 |
p.A328V | PAAD | 1 |
p.P583Q | SKCM | 1 |
p.S465N | SKCM | 1 |
p.R90* | BLCA | 1 |
p.A315V | STAD | 1 |
p.S361R | COAD | 1 |
p.E277K | SKCM | 1 |
p.Q216* | LUAD | 1 |
p.G374* | PRAD | 1 |
p.I45L | BLCA | 1 |
p.D388N | SKCM | 1 |
p.M195I | ESCA | 1 |
p.G206R | SKCM | 1 |
p.D162N | ESCA | 1 |
p.A310T | COAD | 1 |
p.A293T | UCEC | 1 |
p.L80I | ESCA | 1 |
p.E422V | SKCM | 1 |
p.Q29X | THYM | 1 |
p.Q138L | SARC | 1 |
p.A278V | UCEC | 1 |
p.R175Q | LGG | 1 |
p.P188Q | BLCA | 1 |
p.R412Q | LUAD | 1 |
p.A391V | LUAD | 1 |
p.Q103H | CHOL | 1 |
p.E422Q | BLCA | 1 |
p.A566V | SKCM | 1 |
p.D488N | SKCM | 1 |
p.A310T | STAD | 1 |
p.G451E | BLCA | 1 |
p.E96K | STAD | 1 |
p.S459F | SKCM | 1 |
p.A156T | COAD | 1 |
p.H101P | LUAD | 1 |
p.N256S | LIHC | 1 |
p.S508F | SKCM | 1 |
p.D247N | SKCM | 1 |
p.G241A | LUAD | 1 |
p.K106R | BLCA | 1 |
p.E277D | CESC | 1 |
p.R439C | UCEC | 1 |
p.D471E | HNSC | 1 |
p.E96G | STAD | 1 |
p.S459A | READ | 1 |
p.Q103L | SKCM | 1 |
p.R65L | LUAD | 1 |
p.A144T | HNSC | 1 |
p.S459F | LUAD | 1 |
p.Q216H | CHOL | 1 |
p.Q456* | SKCM | 1 |
p.K507T | BLCA | 1 |
p.D38N | LUAD | 1 |
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TissGeneCNV for FAM71A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM71A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM71A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM71A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM71A |
TissGeneDrug for FAM71A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM71A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |