TissGeneSummary for WFDC5 |
Gene summary |
Basic gene information | Gene symbol | WFDC5 |
Gene name | WAP four-disulfide core domain 5 | |
Synonyms | PRG5|WAP1|dJ211D12.5 | |
Cytomap | UCSC genome browser: 20q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_145652.3, | |
Description | WAP four-disulfide core domain protein 5p53-responsive gene 5 proteinprotease inhibitor WAP1putative protease inhibitor WAP1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605161 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175121 | ||
Vega : OTTHUMG00000046411 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WFDC5 | |
BioGPS: 149708 | ||
Pathway | NCI Pathway Interaction Database: WFDC5 | |
KEGG: WFDC5 | ||
REACTOME: WFDC5 | ||
Pathway Commons: WFDC5 | ||
Context | iHOP: WFDC5 | |
ligand binding site mutation search in PubMed: WFDC5 | ||
UCL Cancer Institute: WFDC5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of WFDC5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for WFDC5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.107699399 | -0.699355399 | -2.408344 | 1.97E-07 | 8.55E-07 |
LUSC | 2.209741777 | -1.167005281 | 3.376747059 | 1.72E-10 | 6.32E-10 |
KIRP | -0.075352524 | -1.501790024 | 1.4264375 | 0.0197 | 0.039970498 |
PRAD | -0.184087861 | 1.035744832 | -1.219832692 | 0.00406 | 0.0108315 |
LUAD | -2.278725261 | -1.225642503 | -1.053082759 | 7.91E-05 | 0.000203465 |
Top |
TissGene-miRNA for WFDC5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for WFDC5 |
TissGeneSNV for WFDC5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A158T | UCEC | 1 |
p.P56L | BRCA | 1 |
p.D101Y | LUAD | 1 |
p.P56H | LUAD | 1 |
p.Q4X | LIHC | 1 |
p.S5N | SKCM | 1 |
p.A121D | BRCA | 1 |
p.R87S | LUAD | 1 |
p.R68C | BRCA | 1 |
p.R68H | KICH | 1 |
p.P120H | KIRC | 1 |
p.R107Q | SKCM | 1 |
p.R169Q | SKCM | 1 |
p.R87C | STAD | 1 |
p.Q4* | LIHC | 1 |
p.P120H | COAD | 1 |
p.D99N | COAD | 1 |
p.K77M | LUAD | 1 |
Top |
TissGeneCNV for WFDC5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for WFDC5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for WFDC5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for WFDC5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for WFDC5 |
TissGeneDrug for WFDC5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for WFDC5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 1 | BeFree |