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| TissGeneSummary for CCT8L2 |
 Gene summary |
| Basic gene information | Gene symbol | CCT8L2 |
| Gene name | chaperonin containing TCP1, subunit 8 (theta)-like 2 | |
| Synonyms | CESK1 | |
| Cytomap | UCSC genome browser: 22q11.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014406.4, | |
| Description | T-complex protein 1putative T-complex protein 1 subunit theta-like 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000198445 | ||
| HPRD : 16708 | ||
| Vega : OTTHUMG00000141302 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCT8L2 | |
| BioGPS: 150160 | ||
| Pathway | NCI Pathway Interaction Database: CCT8L2 | |
| KEGG: CCT8L2 | ||
| REACTOME: CCT8L2 | ||
| Pathway Commons: CCT8L2 | ||
| Context | iHOP: CCT8L2 | |
| ligand binding site mutation search in PubMed: CCT8L2 | ||
| UCL Cancer Institute: CCT8L2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CCT8L2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CCT8L2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CCT8L2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CCT8L2 |
| TissGeneSNV for CCT8L2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L402P | KIRC | 2 |
| p.G492E | SKCM | 2 |
| p.R91Q | STAD | 2 |
| p.G384E | SKCM | 2 |
| p.E28K | SKCM | 2 |
| p.V40I | SKCM | 1 |
| p.Q131L | HNSC | 1 |
| p.R91L | PRAD | 1 |
| p.M467I | COAD | 1 |
| p.P449S | SKCM | 1 |
| p.P544S | SKCM | 1 |
| p.R20K | KIRP | 1 |
| p.T305K | PAAD | 1 |
| p.C50Y | COAD | 1 |
| p.T112M | STAD | 1 |
| p.C50F | ESCA | 1 |
| p.G311D | SKCM | 1 |
| p.V46A | ACC | 1 |
| p.A207G | LUAD | 1 |
| p.W320* | SKCM | 1 |
| p.S262Y | STAD | 1 |
| p.D308N | KICH | 1 |
| p.E21K | LUAD | 1 |
| p.A259T | SKCM | 1 |
| p.P253Q | LUAD | 1 |
| p.T258M | SKCM | 1 |
| p.A38V | SKCM | 1 |
| p.G102R | SKCM | 1 |
| p.K309T | ESCA | 1 |
| p.G395S | UCEC | 1 |
| p.A207E | LUAD | 1 |
| p.G503R | SKCM | 1 |
| p.G384V | LUAD | 1 |
| p.W189* | SKCM | 1 |
| p.L296F | PRAD | 1 |
| p.D275N | SKCM | 1 |
| p.G411E | SKCM | 1 |
| p.P256S | THYM | 1 |
| p.T549I | HNSC | 1 |
| p.V313L | HNSC | 1 |
| p.A453V | STAD | 1 |
| p.R429K | LUAD | 1 |
| p.E416X | COAD | 1 |
| p.G226E | PRAD | 1 |
| p.H54Q | LUAD | 1 |
| p.I498V | LIHC | 1 |
| p.R56Q | GBM | 1 |
| p.L127Q | PAAD | 1 |
| p.G204R | ESCA | 1 |
| p.E322Q | TGCT | 1 |
| p.A16T | LUAD | 1 |
| p.P410T | SKCM | 1 |
| p.F400L | LUSC | 1 |
| p.K551T | STAD | 1 |
| p.G473C | LGG | 1 |
| p.N487I | PRAD | 1 |
| p.G221E | SKCM | 1 |
| p.S262C | HNSC | 1 |
| p.S237R | ESCA | 1 |
| p.P344T | DLBC | 1 |
| p.D215N | SKCM | 1 |
| p.E29K | SKCM | 1 |
| p.D462H | LUAD | 1 |
| p.V392I | STAD | 1 |
| p.Q513H | LUAD | 1 |
| p.L183P | COAD | 1 |
| p.A8V | SKCM | 1 |
| p.Q530K | LUAD | 1 |
| p.V109I | SKCM | 1 |
| p.K524R | ESCA | 1 |
| p.P340H | LUAD | 1 |
| p.E416K | SKCM | 1 |
| p.E10X | PAAD | 1 |
| p.D405H | LUAD | 1 |
| p.V108M | UCEC | 1 |
| p.P200L | LUAD | 1 |
| p.P340T | LUAD | 1 |
| p.E302K | BLCA | 1 |
| p.G210R | STAD | 1 |
| p.L304F | HNSC | 1 |
| p.R202S | BLCA | 1 |
| p.P410A | BLCA | 1 |
| p.D195Y | LUAD | 1 |
| p.W88C | KIRC | 1 |
| p.P256A | COAD | 1 |
| p.G71E | SKCM | 1 |
| p.L150M | HNSC | 1 |
| p.R386P | LUAD | 1 |
| p.G211E | SKCM | 1 |
| p.C206* | LUAD | 1 |
| p.G554E | SKCM | 1 |
| p.P157T | UCEC | 1 |
| p.V313M | GBM | 1 |
| p.L267V | LUSC | 1 |
| p.E214K | SKCM | 1 |
| p.G503X | READ | 1 |
| p.S36R | UCEC | 1 |
| p.D275H | HNSC | 1 |
| p.E531D | UCEC | 1 |
| p.M478I | SKCM | 1 |
| p.N487H | STAD | 1 |
| p.E454D | UCEC | 1 |
| p.F59L | LUSC | 1 |
| p.A255E | LUAD | 1 |
| p.R260H | STAD | 1 |
| p.E301K | SKCM | 1 |
| p.P449L | SKCM | 1 |
| p.G479S | SKCM | 1 |
| p.R505Q | LUSC | 1 |
| p.S101I | KIRC | 1 |
| p.A106S | LGG | 1 |
| p.G221V | UCEC | 1 |
| p.E27G | LUSC | 1 |
| p.S197G | LUSC | 1 |
| p.G204V | LUAD | 1 |
| p.A135V | SKCM | 1 |
| p.R133W | COAD | 1 |
| p.E509K | BLCA | 1 |
| p.S162F | SKCM | 1 |
| p.A255S | STAD | 1 |
| p.A39S | SARC | 1 |
| p.L553F | SKCM | 1 |
| p.E364Q | LUAD | 1 |
| p.L180F | LUAD | 1 |
| p.R129C | UCEC | 1 |
| p.E193K | SKCM | 1 |
| p.M177I | SKCM | 1 |
| p.R386Q | UCEC | 1 |
| p.S175Y | LUAD | 1 |
| p.W320X | SKCM | 1 |
| p.S25I | READ | 1 |
| p.S387R | HNSC | 1 |
| p.E134K | THYM | 1 |
| p.M417I | BLCA | 1 |
| p.V205E | OV | 1 |
| p.G52S | SKCM | 1 |
| p.R14W | PRAD | 1 |
| p.V499I | LUSC | 1 |
| p.G94E | SKCM | 1 |
| p.H84Q | SKCM | 1 |
| p.C206Y | LUAD | 1 |
| p.P53S | LGG | 1 |
| p.Q276K | STAD | 1 |
| p.E531D | HNSC | 1 |
| p.D462V | LUAD | 1 |
| p.R378K | SKCM | 1 |
| p.R378W | LUAD | 1 |
| p.A251S | LUSC | 1 |
| p.V521I | BRCA | 1 |
| p.K309R | SKCM | 1 |
| p.K346Q | SKCM | 1 |
| p.L430F | SKCM | 1 |
| p.D308G | ESCA | 1 |
| p.W365X | DLBC | 1 |
| p.G226W | HNSC | 1 |
| p.T258M | UCEC | 1 |
| p.R343W | ESCA | 1 |
| p.E10* | PAAD | 1 |
| p.S327C | HNSC | 1 |
| p.A119S | LUSC | 1 |
| p.E509G | HNSC | 1 |
| p.V392I | UCEC | 1 |
| p.M177L | LUAD | 1 |
| p.G65E | SKCM | 1 |
| p.G345D | PRAD | 1 |
| p.T258M | OV | 1 |
| p.A44D | OV | 1 |
| p.A207V | OV | 1 |
| p.S216F | SKCM | 1 |
| p.P85Q | LUSC | 1 |
| p.A268G | BLCA | 1 |
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| TissGeneCNV for CCT8L2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CCT8L2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CCT8L2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CCT8L2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CCT8L2 |
| TissGeneDrug for CCT8L2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CCT8L2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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