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| TissGeneSummary for CTRL |
 Gene summary |
| Basic gene information | Gene symbol | CTRL |
| Gene name | chymotrypsin-like | |
| Synonyms | CTRL1 | |
| Cytomap | UCSC genome browser: 16q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001907.2, | |
| Description | chymotrypsin-like protease CTRL-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 118888 | |
| HGNC : HGNC | ||
| HPRD : 00344 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CTRL | |
| BioGPS: 1506 | ||
| Pathway | NCI Pathway Interaction Database: CTRL | |
| KEGG: CTRL | ||
| REACTOME: CTRL | ||
| Pathway Commons: CTRL | ||
| Context | iHOP: CTRL | |
| ligand binding site mutation search in PubMed: CTRL | ||
| UCL Cancer Institute: CTRL | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of CTRL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CTRL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CTRL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CTRL |
| TissGeneSNV for CTRL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S115F | SKCM | 1 |
| p.P217H | COAD | 1 |
| p.E97K | BLCA | 1 |
| p.D53N | BRCA | 1 |
| p.P98H | STAD | 1 |
| p.R136L | STAD | 1 |
| p.C220Y | LIHC | 1 |
| p.R242C | PRAD | 1 |
| p.X265S | ACC | 1 |
| p.N264S | LIHC | 1 |
| p.T154M | UCEC | 1 |
| p.C19* | LUAD | 1 |
| p.R188W | COAD | 1 |
| p.P22S | BLCA | 1 |
| p.R92Q | LGG | 1 |
| p.V104I | READ | 1 |
| p.R92X | LIHC | 1 |
| p.R136H | STAD | 1 |
| p.L125P | LUAD | 1 |
| p.D91H | BLCA | 1 |
| p.N146K | BLCA | 1 |
| p.Q52X | ESCA | 1 |
| p.R249P | HNSC | 1 |
| p.S105F | BLCA | 1 |
| p.Q52* | ESCA | 1 |
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| TissGeneCNV for CTRL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CTRL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BM919850 | CTRL-CTRL | chr16:67964696 | chr16:67963780 | |
| Chimerdb3.0 | ChiTaRs | NA | BF063267 | LMF2-CTRL | chr22:50941695 | chr16:67964013 |
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| TissGeneNet for CTRL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CTRL, SERPINA3, ING1 (tumor) | CTRL, SERPINA3, ING1 (normal) |
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| TissGeneProg for CTRL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CTRL |
| TissGeneDrug for CTRL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CTRL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0024419 | Waldenstrom Macroglobulinemia | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0265962 | Ichthyosis linearis circumflexa | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
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